Entity Details

Primary name AMRP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30533
EntryNameAMRP_HUMAN
FullNameAlpha-2-macroglobulin receptor-associated protein
TaxID9606
Evidenceevidence at protein level
Length357
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesLRPAP1

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002091 negative regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005801 cis-Golgi network
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0008201 heparin binding
GO:0009986 cell surface
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0012505 endomembrane system
GO:0031904 endosome lumen
GO:0032091 negative regulation of protein binding
GO:0035473 lipase binding
GO:0048018 receptor ligand activity
GO:0048019 receptor antagonist activity
GO:0048237 rough endoplasmic reticulum lumen
GO:0048259 regulation of receptor-mediated endocytosis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060548 negative regulation of cell death
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0150093 amyloid-beta clearance by transcytosis
GO:1900116 extracellular negative regulation of signal transduction
GO:1900222 negative regulation of amyloid-beta clearance
GO:1900223 positive regulation of amyloid-beta clearance

Subcellular Location

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Subcellular Location
Cell surface
Endoplasmic reticulum-Golgi intermediate compartment lumen
Endosome lumen
Golgi apparatus
Golgi apparatus lumen
Rough endoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1DomainDomain
IPR010483 Alpha-2-macroglobulin RAP, C-terminalDomainDomain
IPR036744 RAP domain superfamilyFamilyHomologous superfamily
IPR037999 Alpha-2-macroglobulin RAP, domain 3DomainDomain
IPR038001 Alpha-2-macroglobulin RAP, domain 2DomainDomain
IPR038003 Alpha-2-macroglobulin receptor-associated proteinFamilyFamily

Diseases

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Interactions

23 interactions

InteractorPartnerSourcesPublicationsLink
AMRP_HUMANDPOA2_HUMANBioGRID, HPRD, IntAct16169070 details
AMRP_HUMANRTN4_HUMANBioGRID, HPRD, IntAct16169070 details
AMRP_HUMANPPM1G_HUMANHPRD, IntAct16169070 details
AMRP_HUMANRBP2_HUMANBioGRID, IntAct20936779 details
AMRP_HUMANETV7_HUMANBioGRID, IntAct21988832 details
AMRP_HUMANSORT_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct10085125 18687776 19122660 20584990 9013611 9927419 details
AMRP_HUMANVLDLR_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct10571241 12899622 20223215 28514442 7592875 8083232 details
AMRP_HUMANSORL_HUMANbhf-ucl, BioGRID, HPRD, IntAct11294867 11557679 17326667 26858303 28514442 8940146 details
AMRP_HUMANLRP1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, UniProt10747918 1374383 16101684 1718973 17326667 20030366 28514442 details
AMRP_HUMANASPH_HUMANBioGRID, IntAct32296183 details
AMRP_HUMANLRP8_HUMANBioGRID, DIP, HPRD, IntAct10231386 12899622 16101684 20223215 28514442 details
AMRP_HUMANLRP2_HUMANBioGRID, HPRD, IntAct11912251 16101684 28514442 7512726 details
AMRP_HUMANLDLR_HUMANBioGRID, HPRD, IntAct, UniProt20030366 28514442 7822276 details
AMRP_HUMANA4_HUMANIntAct32814053 details
AMRP_HUMANRAF1_HUMANBioGRID10783161 details
AMRP_HUMANGNDS_HUMANBioGRID10783161 details
AMRP_HUMANSMAD2_HUMANIntAct20195357 details
AMRP_HUMANLRP1B_HUMANBioGRID, HPRD, IntAct11384978 28514442 details
AMRP_HUMAN4EBP1_HUMANBioGRID16798736 details
AMRP_HUMANMTOR_HUMANBioGRID16798736 details
AMRP_HUMANP53_HUMANBioGRID15489903 details
AMRP_HUMANMK03_HUMANHPRD15342917 details
AMRP_HUMANMK01_HUMANHPRD15342917 details