Entity Details

Primary name FCG2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31994
EntryNameFCG2B_HUMAN
FullNameLow affinity immunoglobulin gamma Fc region receptor II-b
TaxID9606
Evidenceevidence at protein level
Length310
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesFCGR2B

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001811 negative regulation of type I hypersensitivity
GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity
GO:0001818 negative regulation of cytokine production
GO:0002266 follicular dendritic cell activation
GO:0002313 mature B cell differentiation involved in immune response
GO:0002316 follicular B cell differentiation
GO:0002436 immune complex clearance by monocytes and macrophages
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0002622 regulation of B cell antigen processing and presentation
GO:0002638 negative regulation of immunoglobulin production
GO:0002819 regulation of adaptive immune response
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0002922 positive regulation of humoral immune response
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004888 transmembrane signaling receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0009617 response to bacterium
GO:0009897 external side of plasma membrane
GO:0010469 regulation of signaling receptor activity
GO:0016032 viral process
GO:0016064 immunoglobulin mediated immune response
GO:0019772 low-affinity IgG receptor activity
GO:0019864 IgG binding
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0021549 cerebellum development
GO:0030889 negative regulation of B cell proliferation
GO:0032693 negative regulation of interleukin-10 production
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043031 negative regulation of macrophage activation
GO:0043197 dendritic spine
GO:0043318 negative regulation of cytotoxic T cell degranulation
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050765 negative regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050776 regulation of immune response
GO:0050777 negative regulation of immune response
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0050869 negative regulation of B cell activation
GO:0071219 cellular response to molecule of bacterial origin
GO:0090264 regulation of immune complex clearance by monocytes and macrophages
GO:1901216 positive regulation of neuron death
GO:1902564 negative regulation of neutrophil activation
GO:1902950 regulation of dendritic spine maintenance
GO:1904646 cellular response to amyloid-beta
GO:1905898 positive regulation of response to endoplasmic reticulum stress
GO:2001199 negative regulation of dendritic cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00005 EtanerceptDrugbankbiotech
DB00028 Human immunoglobulin GDrugbankbiotech
DB00054 AbciximabDrugbankbiotech
DB00081 TositumomabDrugbankbiotech
DB00087 AlemtuzumabDrugbankbiotech
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB00110 PalivizumabDrugbankbiotech
DB00111 DaclizumabDrugbankbiotech
DB00112 BevacizumabDrugbankbiotech
DB11767 SarilumabDrugbankbiotech