Entity Details

Primary name PRDX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32119
EntryNamePRDX2_HUMAN
FullNamePeroxiredoxin-2
TaxID9606
Evidenceevidence at protein level
Length198
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPRDX2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002357 defense response to tumor cell
GO:0002536 respiratory burst involved in inflammatory response
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006979 response to oxidative stress
GO:0008379 thioredoxin peroxidase activity
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0016209 antioxidant activity
GO:0019430 removal of superoxide radicals
GO:0030194 positive regulation of blood coagulation
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0034599 cellular response to oxidative stress
GO:0042098 T cell proliferation
GO:0042744 hydrogen peroxide catabolic process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045321 leukocyte activation
GO:0045454 cell redox homeostasis
GO:0045581 negative regulation of T cell differentiation
GO:0048538 thymus development
GO:0048872 homeostasis of number of cells
GO:0070062 extracellular exosome
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidantDomainDomain
IPR013766 Thioredoxin domainDomainDomain
IPR019479 Peroxiredoxin, C-terminalDomainDomain
IPR024706 Peroxiredoxin, AhpC-typeFamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02153 3-sulfino-L-alanineDrugbanksmall molecule
DB04048 N-Carbamoyl-AlanineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
PRDX2_HUMANA2MG_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANCDC37_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANEXOC6_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANECSIT_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANIFIT5_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANMAST1_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANRNF32_HUMANBioGRID, IntAct21163940 details
PRDX2_HUMANCAH4_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMAN1433Z_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANNLGN3_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANBAD_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANSAT1_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANUTY_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANPRDX4_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANCSN5_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANCD320_HUMANBioGRID, IntAct21988832 details
PRDX2_HUMANA4_HUMANBioGRID21832049 details
PRDX2_HUMANAPOE_HUMANBioGRID21163940 details
PRDX2_HUMANPSN1_HUMANBioGRID21163940 details
PRDX2_HUMANTXND5_HUMANBioGRID23713588 details
PRDX2_HUMANTHIO_HUMANBioGRID, DIP, MINT17557078 25402766 26344197 details
PRDX2_HUMANRTL9_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRDX2_HUMANCOEA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRDX2_HUMANPRDX3_HUMANBioGRID, IntAct26344197 27173435 unassigned1312 details
PRDX2_HUMANKCTD5_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRDX2_HUMANMAK_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRDX2_HUMANSTAT3_HUMANDIP25402766 details
PRDX2_HUMANDNM3A_HUMANIntAct30245403 details
PRDX2_HUMANITA4_HUMANBioGRID22623428 details
PRDX2_HUMANESR1_HUMANBioGRID23576398 details
PRDX2_HUMANU2AF2_HUMANBioGRID26641092 details
PRDX2_HUMANAKTIP_HUMANBioGRID27512140 details
PRDX2_HUMANPRDX2_HUMANBioGRID29339092 details
PRDX2_HUMANDPYL2_HUMANBioGRID30315937 details
PRDX2_HUMANPGFRB_HUMANHPRD15902258 details
PRDX2_HUMANSUMO4_HUMANHPRD16236267 details