Entity Details

Primary name NAC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32418
EntryNameNAC1_HUMAN
FullNameSodium/calcium exchanger 1
TaxID9606
Evidenceevidence at protein level
Length973
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesSLC8A1

GO terms

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GOName
GO:0002026 regulation of the force of heart contraction
GO:0002027 regulation of heart rate
GO:0002028 regulation of sodium ion transport
GO:0005432 calcium:sodium antiporter activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006883 cellular sodium ion homeostasis
GO:0006936 muscle contraction
GO:0007584 response to nutrient
GO:0008092 cytoskeletal protein binding
GO:0009749 response to glucose
GO:0010468 regulation of gene expression
GO:0010649 regulation of cell communication by electrical coupling
GO:0010763 positive regulation of fibroblast migration
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014069 postsynaptic density
GO:0014704 intercalated disc
GO:0014829 vascular associated smooth muscle contraction
GO:0015491 cation:cation antiporter activity
GO:0016020 membrane
GO:0021537 telencephalon development
GO:0030001 metal ion transport
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030424 axon
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030506 ankyrin binding
GO:0033198 response to ATP
GO:0034614 cellular response to reactive oxygen species
GO:0035725 sodium ion transmembrane transport
GO:0035902 response to immobilization stress
GO:0035994 response to muscle stretch
GO:0036376 sodium ion export across plasma membrane
GO:0042383 sarcolemma
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043679 axon terminus
GO:0044325 transmembrane transporter binding
GO:0044557 relaxation of smooth muscle
GO:0045202 synapse
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0055013 cardiac muscle cell development
GO:0055074 calcium ion homeostasis
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0071313 cellular response to caffeine
GO:0071320 cellular response to cAMP
GO:0071456 cellular response to hypoxia
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071944 cell periphery
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0098703 calcium ion import across plasma membrane
GO:0098719 sodium ion import across plasma membrane
GO:0098735 positive regulation of the force of heart contraction
GO:0098794 postsynapse
GO:0099055 integral component of postsynaptic membrane
GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential
GO:1901660 calcium ion export
GO:1903779 regulation of cardiac conduction
GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001623 DnaJ domainDomainDomain
IPR002987 Sodium/calcium exchanger, isoform 1FamilyFamily
IPR003644 Na-Ca exchanger/integrin-beta4DomainDomain
IPR004836 Sodium/calcium exchanger proteinFamilyFamily
IPR004837 Sodium/calcium exchanger membrane regionDomainDomain
IPR032452 Sodium/calcium exchanger domain, C-terminal extensionDomainDomain
IPR038081 CalX-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB06231 CaldaretDrugbanksmall molecule
DB09498 Strontium chloride Sr-89Swissprotsmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule