Entity Details

Primary name ADA1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35368
EntryNameADA1B_HUMAN
FullNameAlpha-1B adrenergic receptor
TaxID9606
Evidenceevidence at protein level
Length520
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesADRA1B

GO terms

Show/Hide Table
GOName
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0004930 G protein-coupled receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0031965 nuclear membrane
GO:0035556 intracellular signal transduction
GO:0043410 positive regulation of MAPK cascade
GO:0045907 positive regulation of vasoconstriction
GO:0046982 protein heterodimerization activity
GO:0055117 regulation of cardiac muscle contraction
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0150099 neuron-glial cell signaling

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001115 Alpha 1B adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00211 MidodrineDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00298 DapiprazoleDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00346 AlfuzosinDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00388 PhenylephrineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00590 DoxazosinDrugbanksmall molecule
DB00598 LabetalolDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00692 PhentolamineDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00697 TizanidineDrugbanksmall molecule
DB00706 TamsulosinDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00723 MethoxamineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00745 ModafinilDrugbanksmall molecule
DB00800 FenoldopamDrugbanksmall molecule
DB00841 DobutamineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00935 OxymetazolineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01162 TerazosinDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01365 MephentermineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01579 PhendimetrazineDrugbanksmall molecule
DB01608 PericiazineDrugbanksmall molecule
DB01614 AcepromazineDrugbanksmall molecule
DB01622 ThioproperazineDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05469 R450Drugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06207 SilodosinDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06694 XylometazolineDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB09128 BrexpiprazoleDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09202 CirazolineDrugbanksmall molecule
DB09203 SynephrineDrugbanksmall molecule
DB09204 ArotinololDrugbanksmall molecule
DB09205 MoxisylyteDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB11124 RacepinephrineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11278 DL-MethylephedrineDrugbanksmall molecule
DB11577 Indigotindisulfonic acidDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule