Entity Details

Primary name CBS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35520
EntryNameCBS_HUMAN
FullNameCystathionine beta-synthase
TaxID9606
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesCBSL
CBS

GO terms

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GOName
GO:0004122 cystathionine beta-synthase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006535 cysteine biosynthetic process from serine
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0019448 L-cysteine catabolic process
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0030170 pyridoxal phosphate binding
GO:0031625 ubiquitin protein ligase binding
GO:0042262 DNA protection
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043418 homocysteine catabolic process
GO:0046872 metal ion binding
GO:0050421 nitrite reductase (NO-forming) activity
GO:0050667 homocysteine metabolic process
GO:0070025 carbon monoxide binding
GO:0070026 nitric oxide binding
GO:0070814 hydrogen sulfide biosynthetic process
GO:0072341 modified amino acid binding
GO:1904047 S-adenosyl-L-methionine binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000644 CBS domainDomainDomain
IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment siteSiteBinding site
IPR001926 Pyridoxal-phosphate dependent enzymeDomainDomain
IPR005857 Cystathionine beta-synthaseFamilyFamily
IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzymeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00118 AdemetionineDrugbanksmall molecule
DB00133 SerineDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
CBS_HUMANVTA1_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
CBS_HUMANFXR2_HUMANBioGRID, HPRD, IntAct, MINT16189514 21653829 31515488 details
CBS_HUMANHID1_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
CBS_HUMANCBS_HUMANBioGRID, HPRD, IntAct, MINT11173483 11483494 12173932 16189514 19447967 21516116 21900206 25416956 25502805 31515488 details
CBS_HUMANCERT_HUMANBioGRID, IntAct19447967 details
CBS_HUMANUGPA_HUMANBioGRID, IntAct21988832 details
CBS_HUMANDAXX_HUMANBioGRID, IntAct21988832 details
CBS_HUMANKAP0_HUMANBioGRID, MINT21900206 details
CBS_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
CBS_HUMANPSA1_HUMANBioGRID, IntAct25416956 31515488 details
CBS_HUMANAAKG1_HUMANBioGRID, IntAct25416956 details
CBS_HUMANUBS3A_HUMANBioGRID, IntAct25416956 31515488 details
CBS_HUMANECHP_HUMANBioGRID, IntAct25416956 31515488 details
CBS_HUMANPIN1_HUMANBioGRID, IntAct25416956 31515488 details
CBS_HUMANNTAQ1_HUMANBioGRID, IntAct27107012 details
CBS_HUMANCBSL_HUMANBioGRID, HPRD11173483 11483494 12173932 16189514 19447967 21516116 21900206 25416956 details
CBS_HUMANHGS_HUMANBioGRID19019082 details
CBS_HUMANPIAS1_HUMANBioGRID17087506 details
CBS_HUMANPIAS3_HUMANBioGRID17087506 details
CBS_HUMANUBC9_HUMANBioGRID17087506 25416956 32296183 details
CBS_HUMANRANB9_HUMANBioGRID17087506 details
CBS_HUMANCBX4_HUMANBioGRID17087506 details
CBS_HUMANPIAS2_HUMANBioGRID32296183 details
CBS_HUMANZMYM5_HUMANBioGRID32296183 details
CBS_HUMANOGT1_HUMANBioGRID32994395 details
CBS_HUMANHD_HUMANHPRD10434301 9466992 details
CBS_HUMANPA2G4_HUMANBioGRID, IntAct27173435 unassigned1312 details
CBS_HUMANNEK7_HUMANBioGRID, IntAct27173435 unassigned1312 details
CBS_HUMANUBE2N_HUMANBioGRID, IntAct27173435 unassigned1312 details
CBS_HUMANTRAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CBS_HUMANFXR1_HUMANMINT21653829 details