Entity Details

Primary name SRBP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36956
EntryNameSRBP1_HUMAN
FullNameSterol regulatory element-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length1147
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesSREBF1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003062 regulation of heart rate by chemical signal
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006629 lipid metabolic process
GO:0007568 aging
GO:0007623 circadian rhythm
GO:0008203 cholesterol metabolic process
GO:0008286 insulin receptor signaling pathway
GO:0008610 lipid biosynthetic process
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010876 lipid localization
GO:0010883 regulation of lipid storage
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016021 integral component of membrane
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019901 protein kinase binding
GO:0030324 lung development
GO:0030522 intracellular receptor signaling pathway
GO:0031065 positive regulation of histone deacetylation
GO:0031647 regulation of protein stability
GO:0032094 response to food
GO:0032526 response to retinoic acid
GO:0032570 response to progesterone
GO:0032810 sterol response element binding
GO:0032933 SREBP signaling pathway
GO:0032991 protein-containing complex
GO:0033762 response to glucagon
GO:0042493 response to drug
GO:0042789 mRNA transcription by RNA polymerase II
GO:0044877 protein-containing complex binding
GO:0045444 fat cell differentiation
GO:0045471 response to ethanol
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046983 protein dimerization activity
GO:0051591 response to cAMP
GO:0071398 cellular response to fatty acid
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903146 regulation of autophagy of mitochondrion
GO:1903214 regulation of protein targeting to mitochondrion
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Golgi apparatus membrane
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03756 DoconexentDrugbanksmall molecule
DB09539 Omega-3-acid ethyl estersDrugbanksmall molecule
DB11133 Omega-3 fatty acidsDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
SRBP1_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 32814053 details
SRBP1_HUMANSIR1_HUMANBioGRID, UniProt20595232 20817729 details
SRBP1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
SRBP1_HUMANCBP_HUMANBioGRID, DIP, HPRD10235267 16799563 8918891 9651391 9765204 details
SRBP1_HUMANMED15_HUMANBioGRID, DIP10235267 11834832 16799563 18385733 20534441 details
SRBP1_HUMANMED1_HUMANBioGRID, DIP10235267 16799563 details
SRBP1_HUMANMED6_HUMANBioGRID, DIP10235267 11834832 16799563 details
SRBP1_HUMANCDK8_HUMANBioGRID, DIP11834832 16799563 details
SRBP1_HUMANHD_HUMANIntAct32814053 details
SRBP1_HUMANLMNA_HUMANBioGRID, HPRD11929849 19727227 details
SRBP1_HUMANTWST2_HUMANBioGRID, HPRD14654692 details
SRBP1_HUMANTYY1_HUMANBioGRID, HPRD10224053 details
SRBP1_HUMANSP1_HUMANBioGRID, HPRD10224053 10235267 details
SRBP1_HUMANNR0B1_HUMANBioGRID, HPRD11713202 details
SRBP1_HUMANMK03_HUMANBioGRID, HPRD10627507 10915800 details
SRBP1_HUMANMK01_HUMANBioGRID, HPRD10627507 10915800 details
SRBP1_HUMANFBXW7_HUMANBioGRID16054087 19126544 24298052 26759235 27579997 32301540 details
SRBP1_HUMANKLF13_HUMANBioGRID16303770 details
SRBP1_HUMANEP300_HUMANBioGRID10235267 12640139 14615581 20534441 20817729 details
SRBP1_HUMANANDR_HUMANBioGRID18245227 details
SRBP1_HUMANMED23_HUMANBioGRID10235267 11834832 16799563 details
SRBP1_HUMANMED7_HUMANBioGRID10235267 11834832 details
SRBP1_HUMANMED13_HUMANBioGRID10235267 11834832 16799563 details
SRBP1_HUMANMED12_HUMANBioGRID10235267 11834832 16799563 details
SRBP1_HUMANMED14_HUMANBioGRID10235267 11834832 16799563 details
SRBP1_HUMANMED24_HUMANBioGRID10235267 11834832 16799563 details
SRBP1_HUMANMED26_HUMANBioGRID10235267 11834832 16799563 details
SRBP1_HUMANHNF4A_HUMANBioGRID17636037 20817729 details
SRBP1_HUMANMED25_HUMANBioGRID11834832 16799563 details
SRBP1_HUMANMED17_HUMANBioGRID11834832 16799563 details
SRBP1_HUMANGSK3B_HUMANBioGRID19126544 details
SRBP1_HUMANZBT7C_HUMANBioGRID22331133 details
SRBP1_HUMANSRBP2_HUMANBioGRID15798184 details
SRBP1_HUMANSRBP1_HUMANBioGRID, HPRD15798184 9634703 details
SRBP1_HUMANATX1L_HUMANBioGRID16713569 details
SRBP1_HUMANSMRD3_HUMANBioGRID, HPRD14701856 details
SRBP1_HUMANID2_HUMANBioGRID10585876 details
SRBP1_HUMANID3_HUMANBioGRID, HPRD10585876 details
SRBP1_HUMANANM5_HUMANBioGRID26759235 details
SRBP1_HUMANPLK1_HUMANBioGRID27579997 details
SRBP1_HUMANNR5A2_HUMANBioGRID17283069 details
SRBP1_HUMANSMUF1_HUMANBioGRID32301540 details
SRBP1_HUMANP53_HUMANIntAct22265415 details
SRBP1_HUMANHS90B_HUMANIntAct22939624 details
SRBP1_HUMANMEN1_HUMANMINT25962847 details
SRBP1_HUMANUBC9_HUMANBioGRID, HPRD12615929 details
SRBP1_HUMANTRRAP_HUMANBioGRID20534441 details
SRBP1_HUMANKAT2A_HUMANBioGRID20534441 details
SRBP1_HUMANATM_HUMANBioGRID20534441 details
SRBP1_HUMANGCN1_HUMANBioGRID20534441 details
SRBP1_HUMANTAD2B_HUMANBioGRID20534441 details
SRBP1_HUMANTADA3_HUMANBioGRID20534441 details
SRBP1_HUMANRUVB2_HUMANBioGRID20534441 details
SRBP1_HUMANMED21_HUMANBioGRID11834832 details
SRBP1_HUMANZBT7A_HUMANBioGRID18682402 details
SRBP1_HUMANSCAP_HUMANBioGRID29097707 9242699 details
SRBP1_HUMANINSI1_HUMANBioGRID12242332 details
SRBP1_HUMANINSI2_HUMANBioGRID12242332 details
SRBP1_HUMANEGF_HUMANBioGRID19727227 details
SRBP1_HUMANHS90A_HUMANBioGRID22939624 details
SRBP1_HUMANERLN2_HUMANBioGRID24217618 details
SRBP1_HUMANKLF5_HUMANBioGRID18774944 details
SRBP1_HUMANRPB1_HUMANBioGRID29033323 details
SRBP1_HUMANGOLM1_HUMANBioGRID29097707 details
SRBP1_HUMANMDM2_HUMANBioGRID32332706 details
SRBP1_HUMANSUMO1_HUMANHPRD12615929 details
SRBP1_HUMANESR1_HUMANHPRD12021179 details
SRBP1_HUMANESR2_HUMANHPRD12021179 details