Entity Details

Primary name MTOR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42345
EntryNameMTOR_HUMAN
FullNameSerine/threonine-protein kinase mTOR
TaxID9606
Evidenceevidence at protein level
Length2549
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMTOR

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001156 TFIIIC-class transcription factor complex binding
GO:0001558 regulation of cell growth
GO:0001933 negative regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002296 T-helper 1 cell lineage commitment
GO:0003007 heart morphogenesis
GO:0003179 heart valve morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005979 regulation of glycogen biosynthetic process
GO:0006112 energy reserve metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006468 protein phosphorylation
GO:0007040 lysosome organization
GO:0007281 germ cell development
GO:0007420 brain development
GO:0007569 cell aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010507 negative regulation of autophagy
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010831 positive regulation of myotube differentiation
GO:0010976 positive regulation of neuron projection development
GO:0012505 endomembrane system
GO:0014042 positive regulation of neuron maturation
GO:0014736 negative regulation of muscle atrophy
GO:0014823 response to activity
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021510 spinal cord development
GO:0030163 protein catabolic process
GO:0030425 dendrite
GO:0030838 positive regulation of actin filament polymerization
GO:0031397 negative regulation of protein ubiquitination
GO:0031529 ruffle organization
GO:0031641 regulation of myelination
GO:0031667 response to nutrient levels
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032095 regulation of response to food
GO:0032148 activation of protein kinase B activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032868 response to insulin
GO:0032956 regulation of actin cytoskeleton organization
GO:0034198 cellular response to amino acid starvation
GO:0035176 social behavior
GO:0035264 multicellular organism growth
GO:0038202 TORC1 signaling
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0043025 neuronal cell body
GO:0043087 regulation of GTPase activity
GO:0043200 response to amino acid
GO:0043276 anoikis
GO:0043278 response to morphine
GO:0043610 regulation of carbohydrate utilization
GO:0045182 translation regulator activity
GO:0045335 phagocytic vesicle
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045670 regulation of osteoclast differentiation
GO:0045727 positive regulation of translation
GO:0045792 negative regulation of cell size
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048255 mRNA stabilization
GO:0048511 rhythmic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050882 voluntary musculoskeletal movement
GO:0051219 phosphoprotein binding
GO:0051496 positive regulation of stress fiber assembly
GO:0051549 positive regulation of keratinocyte migration
GO:0051647 nucleus localization
GO:0051897 positive regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060048 cardiac muscle contraction
GO:0060135 maternal process involved in female pregnancy
GO:0060252 positive regulation of glial cell proliferation
GO:0060999 positive regulation of dendritic spine development
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to leucine
GO:0071456 cellular response to hypoxia
GO:0090335 regulation of brown fat cell differentiation
GO:0090559 regulation of membrane permeability
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:0099547 regulation of translation at synapse, modulating synaptic transmission
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901216 positive regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1903691 positive regulation of wound healing, spreading of epidermal cells
GO:1904000 positive regulation of eating behavior
GO:1904056 positive regulation of cholangiocyte proliferation
GO:1904058 positive regulation of sensory perception of pain
GO:1904059 regulation of locomotor rhythm
GO:1904193 negative regulation of cholangiocyte apoptotic process
GO:1904197 positive regulation of granulosa cell proliferation
GO:1904206 positive regulation of skeletal muscle hypertrophy
GO:1904213 negative regulation of iodide transmembrane transport
GO:1904690 positive regulation of cytoplasmic translational initiation
GO:1990253 cellular response to leucine starvation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Golgi apparatus membrane
Lysosome
Lysosome membrane
Microsome membrane
Mitochondrion outer membrane
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR009076 FKBP12-rapamycin binding domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR024585 Domain of unknown function DUF3385, target of rapamycin proteinDomainDomain
IPR026683 Serine/threonine-protein kinase TORFamilyFamily
IPR036738 FKBP12-rapamycin binding domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00337 PimecrolimusDrugbanksmall molecule
DB00877 SirolimusDrugbanksmall molecule
DB01590 EverolimusDrugbanksmall molecule
DB04974 RimiducidDrugbanksmall molecule
DB05210 SF1126Drugbanksmall molecule
DB05241 XL765Drugbanksmall molecule
DB06233 RidaforolimusDrugbanksmall molecule
DB06287 TemsirolimusDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

146 interactions

InteractorPartnerSourcesPublicationsLink
MTOR_HUMANMTOR_HUMANBioGRID, DIP, HPRD, MINT10702316 11438723 12030785 16870609 17360675 18030348 24670654 details
MTOR_HUMANAKT1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10910062 11438723 14970221 15718470 18505677 18566586 18566587 21045808 21177249 21343617 22084251 22337773 23872070 24670654 25241761 25792870 26293922 30639242 details
MTOR_HUMANFKB1A_HUMANBioGRID, DIP, HPRD, IntAct, MINT10089303 15268862 15284440 15467718 15796538 17148612 17991864 20639890 20851351 22664266 26344197 29997244 32131492 7822316 8662507 details
MTOR_HUMANRHEB_HUMANBioGRID, DIP, HPRD, MINT15772076 15854902 15878852 16098514 16631613 16915281 18550814 25351248 details
MTOR_HUMANRICTR_HUMANBioGRID, DIP, HPRD, IntAct, MINT15268862 15467718 15718470 16183647 16221682 16603397 16919458 16962653 17043309 17277771 17386266 17461779 17565979 18030348 18339839 18504440 18505677 18566586 18566587 18570873 19114562 19145465 19446321 19619545 19875983 20427287 20978191 21045808 21177249 21321085 21343617 21376236 21795849 22084251 22285861 22307628 22544753 22990118 23263282 23297343 23872070 23953116 24036451 24375676 25273559 25897075 27043084 29059166 30865892 31665642 details
MTOR_HUMANPRR5L_HUMANBioGRID, IntAct17461779 18030348 details
MTOR_HUMANRPTOR_HUMANBioGRID, DIP, HPRD, IntAct, MINT12150925 12150926 12408816 12665511 12718876 12719976 12747827 15066126 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 1683716516603397 16847060 16919458 16962653 17043309 17277771 17386266 17461779 17565979 18030348 18504440 18505677 18519641 18570873 18722121 18955708 19114562 19145465 19446321 19619545 19875983 20169205 20381137 20427287 21045808 21071439 21177249 21321085 21614075 21795849 22258093 22356909 22424946 22493283 22544753 23263282 23297343 23872070 23911927 23953116 24036451 24337580 24375676 24403073 24516643 25007995 25273559 25332233 25446900 25940091 26348909 26522726 26678875 27043084 29059166 30865892 31601708 details
MTOR_HUMANLST8_HUMANBioGRID, DIP, HPRD, IntAct12408816 12718876 12719976 15066126 15459249 16183647 16798736 17277771 17461779 18030348 18504440 18505677 19446321 20427287 20562859 21321085 22084251 22258093 23636326 26186194 26348909 26678875 27173435 28489822 28514442 32433973 unassigned1312 details
MTOR_HUMANTELO2_HUMANBioGRID, IntAct, UniProt18160036 20801936 details
MTOR_HUMANPREX1_HUMANBioGRID, IntAct17565979 details
MTOR_HUMANDPTOR_HUMANBioGRID, IntAct19446321 22017875 22017877 details
MTOR_HUMANAKTS1_HUMANBioGRID, HPRD, IntAct17277771 17386266 18030348 18570873 19114562 19446321 23953116 details
MTOR_HUMAN4EBP1_HUMANBioGRID, HPRD, IntAct10364159 10779345 10942774 10971657 11438723 11691836 11777913 12105188 12150925 12150926 12604610 12665511 12747827 15066126 15459249 15767663 15854902 16354698 16798736 16824195 17386266 17693255 17991864 18030348 18337751 18722121 18955708 20537536 21460630 21795849 24931163 25686248 30240640 8083223 9092573 9405468 9465032 details
MTOR_HUMANCG025_HUMANBioGRID, MINT21900206 details
MTOR_HUMANCDC37_HUMANBioGRID, MINT21900206 details
MTOR_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
MTOR_HUMANSEPT2_HUMANBioGRID, MINT21900206 details
MTOR_HUMANSIR1_HUMANBioGRID, UniProt21471201 26453307 details
MTOR_HUMANSGK1_HUMANBioGRID, IntAct18570873 27451907 details
MTOR_HUMANB2CL1_HUMANBioGRID, DIP, MINT20080789 26593251 details
MTOR_HUMANMAF1_HUMANBioGRID, DIP20543138 details
MTOR_HUMANUBQL1_HUMANBioGRID, HPRD11853878 details
MTOR_HUMANIRS1_HUMANBioGRID, HPRD11287630 16354680 30240640 details
MTOR_HUMANAAPK1_HUMANBioGRID, HPRD14970221 details
MTOR_HUMANKS6B1_HUMANBioGRID, HPRD10567431 10971657 11279232 11914378 12150925 12150926 12604610 12718876 14679009 15066126 15760907 15809305 15854902 15896331 15899889 15905173 16183647 16922504 17386266 18505677 22544753 25738361 28270148 9465032 details
MTOR_HUMANCLIP1_HUMANBioGRID, HPRD12231510 details
MTOR_HUMANEIF3F_HUMANBioGRID, HPRD16541103 32131492 details
MTOR_HUMANGEPH_HUMANBioGRID, HPRD10325225 details
MTOR_HUMANPA2G4_HUMANBioGRID15896331 details
MTOR_HUMANPROP_HUMANBioGRID11733037 details
MTOR_HUMAN2ABA_HUMANBioGRID10200280 details
MTOR_HUMANSTAT3_HUMANBioGRID, HPRD10660304 15522880 23329839 24931163 details
MTOR_HUMANKPCA_HUMANBioGRID21045808 details
MTOR_HUMAN4EBP2_HUMANBioGRID16798736 details
MTOR_HUMANPDIA3_HUMANBioGRID21321085 details
MTOR_HUMANAMRA1_HUMANBioGRID23524951 details
MTOR_HUMANTRAF6_HUMANBioGRID23911927 details
MTOR_HUMAN1433T_HUMANBioGRID, HPRD10664457 15161933 details
MTOR_HUMANFKBP8_HUMANBioGRID17991864 24205284 details
MTOR_HUMANGBB1_HUMANBioGRID24462769 details
MTOR_HUMANRRAGB_HUMANBioGRID24337580 details
MTOR_HUMANGA45A_HUMANBioGRID23329839 details
MTOR_HUMANSUMO1_HUMANBioGRID20537536 details
MTOR_HUMANDCP2_HUMANBioGRID26098573 details
MTOR_HUMANZNRF2_HUMANBioGRID27244671 details
MTOR_HUMANFBX8_HUMANBioGRID27916606 details
MTOR_HUMANESR1_HUMANBioGRID26522726 details
MTOR_HUMANSKP2_HUMANBioGRID28446188 details
MTOR_HUMANEP300_HUMANBioGRID29033323 details
MTOR_HUMANRASH_HUMANBioGRID30639242 details
MTOR_HUMANRASK_HUMANBioGRID30639242 34079125 details
MTOR_HUMANRASN_HUMANBioGRID30639242 details
MTOR_HUMANUVRAG_HUMANBioGRID25533187 details
MTOR_HUMANWIPI2_HUMANBioGRID30340022 details
MTOR_HUMANRN126_HUMANBioGRID32131492 details
MTOR_HUMANPDPK1_HUMANHPRD, MINT11438723 details
MTOR_HUMANTRAF2_HUMANBioGRID, IntAct14743216 25241761 details
MTOR_HUMANREBL1_HUMANBioGRID, HPRD, MINT16098514 details
MTOR_HUMAN1433Z_HUMANBioGRID, MINT15161933 17277771 details
MTOR_HUMANPRR5_HUMANBioGRID, IntAct17461779 18505677 details
MTOR_HUMANSIN1_HUMANBioGRID, IntAct, MINT, Molecular Connections16962653 17043309 17277771 17461779 18030348 18505677 18566586 18566587 18570873 19875983 21045808 21177249 21376236 22084251 24365180 26293922 details
MTOR_HUMANEIF3B_HUMANBioGRID, IntAct16286006 18423201 21045808 details
MTOR_HUMANPREX2_HUMANBioGRID, IntAct17565979 details
MTOR_HUMANP53_HUMANBioGRID, MINT19619545 details
MTOR_HUMANRUVB1_HUMANBioGRID, UniProt20371770 22544753 details
MTOR_HUMANRL26_HUMANBioGRID, IntAct21045808 21376236 details
MTOR_HUMANTTI1_HUMANBioGRID, UniProt20427287 20810650 22544753 details
MTOR_HUMANLTOR2_HUMANBioGRID, IntAct20381137 22980980 details
MTOR_HUMANSTAT1_HUMANBioGRID, IntAct12807916 19553685 25241761 details
MTOR_HUMANTPC2_HUMANIntAct23394946 details
MTOR_HUMANTPC1_HUMANIntAct23394946 details
MTOR_HUMANRAB1A_HUMANBioGRID, IntAct25446900 details
MTOR_HUMANRRAGC_HUMANBioGRID, IntAct21981924 24337580 25446900 28716898 details
MTOR_HUMANMTMR3_HUMANBioGRID, MINT26787466 details
MTOR_HUMANEMRE_HUMANBioGRID, IntAct27173435 unassigned1312 details
MTOR_HUMANXPO4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MTOR_HUMANXPO6_HUMANBioGRID, IntAct27173435 unassigned1312 details
MTOR_HUMANTHADA_HUMANBioGRID, IntAct27173435 unassigned1312 details
MTOR_HUMANTF3C2_HUMANDIP20543138 details
MTOR_HUMANTF3C5_HUMANDIP20543138 details
MTOR_HUMANULK1_HUMANBioGRID, DIP21460630 23524951 25686248 29321306 details
MTOR_HUMANABL1_HUMANBioGRID10753870 details
MTOR_HUMANAMRP_HUMANBioGRID16798736 details
MTOR_HUMANKPCD_HUMANBioGRID10698949 details
MTOR_HUMANEIF3C_HUMANBioGRID16286006 details
MTOR_HUMANPLD2_HUMANBioGRID, HPRD16837165 details
MTOR_HUMANRAP1A_HUMANBioGRID15854902 details
MTOR_HUMANTERT_HUMANBioGRID, HPRD15843522 details
MTOR_HUMANFBXW7_HUMANBioGRID18787170 29346117 31285543 33086033 details
MTOR_HUMANRL23_HUMANBioGRID21045808 details
MTOR_HUMANRS6_HUMANBioGRID21045808 details
MTOR_HUMANRL23A_HUMANBioGRID21045808 details
MTOR_HUMANRL5_HUMANBioGRID21045808 details
MTOR_HUMANTERF1_HUMANBioGRID18160036 details
MTOR_HUMANUSP9X_HUMANBioGRID22544753 details
MTOR_HUMANRUVB2_HUMANBioGRID22544753 details
MTOR_HUMANSQSTM_HUMANBioGRID21981924 26279575 details
MTOR_HUMANMK08_HUMANBioGRID22493283 details
MTOR_HUMANRRAGD_HUMANBioGRID18497260 28716898 details
MTOR_HUMANPML_HUMANBioGRID16915281 details
MTOR_HUMANBRCA1_HUMANBioGRID22990118 details
MTOR_HUMANDDB1_HUMANBioGRID23297343 details
MTOR_HUMANMAP2_HUMANBioGRID19446321 details
MTOR_HUMANHSP74_HUMANBioGRID18505677 details
MTOR_HUMANEGFR_HUMANBioGRID23956138 details
MTOR_HUMANGBG2_HUMANBioGRID24462769 details
MTOR_HUMANGBB2_HUMANBioGRID24462769 details
MTOR_HUMANGBB3_HUMANBioGRID24462769 details
MTOR_HUMANGNB5_HUMANBioGRID24462769 details
MTOR_HUMANILK_HUMANBioGRID18339839 details
MTOR_HUMANIKKA_HUMANBioGRID18490760 18519641 details
MTOR_HUMANIKKB_HUMANBioGRID18490760 18519641 details
MTOR_HUMANNEMO_HUMANBioGRID18519641 details
MTOR_HUMANIKBA_HUMANBioGRID18519641 details
MTOR_HUMANNBN_HUMANBioGRID23762398 details
MTOR_HUMANTF3C1_HUMANBioGRID20543138 details
MTOR_HUMANKAP0_HUMANBioGRID16963469 details
MTOR_HUMAN5HT6R_HUMANBioGRID23027611 details
MTOR_HUMANMLXIP_HUMANBioGRID25332233 details
MTOR_HUMANMLXPL_HUMANBioGRID25332233 details
MTOR_HUMANPDK1_HUMANBioGRID24516643 details
MTOR_HUMANTNAP3_HUMANBioGRID26043155 29940800 details
MTOR_HUMANRAP2A_HUMANBioGRID25446900 details
MTOR_HUMANPRKN_HUMANBioGRID25007995 details
MTOR_HUMANBRAT1_HUMANBioGRID25657994 details
MTOR_HUMANM3K3_HUMANBioGRID26279575 details
MTOR_HUMANHD_HUMANBioGRID25351248 details
MTOR_HUMANIRS2_HUMANBioGRID27742835 details
MTOR_HUMANMDM4_HUMANBioGRID28270148 details
MTOR_HUMANLAMP1_HUMANBioGRID28199306 details
MTOR_HUMANLARP1_HUMANBioGRID25940091 details
MTOR_HUMANBECN1_HUMANBioGRID25533187 details
MTOR_HUMANPI3R4_HUMANBioGRID25533187 details
MTOR_HUMANPK3C3_HUMANBioGRID25533187 details
MTOR_HUMANRUBIC_HUMANBioGRID25533187 details
MTOR_HUMANLANC2_HUMANBioGRID25273559 details
MTOR_HUMANLAMP2_HUMANBioGRID28199315 29940807 details
MTOR_HUMANSHOC2_HUMANBioGRID30865892 details
MTOR_HUMANTBK1_HUMANBioGRID28716898 details
MTOR_HUMANTRI37_HUMANBioGRID29940807 details
MTOR_HUMANWWOX_HUMANBioGRID24008736 details
MTOR_HUMANMUC18_HUMANBioGRID31665642 details
MTOR_HUMANUBR5_HUMANBioGRID32867711 details
MTOR_HUMANLNP_HUMANBioGRID32433973 details
MTOR_HUMANKS6B2_HUMANHPRD11733037 details
MTOR_HUMANKS6A1_HUMANHPRD15905173 details