Entity Details

Primary name GATA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43694
EntryNameGATA4_HUMAN
FullNameTranscription factor GATA-4
TaxID9606
Evidenceevidence at protein level
Length442
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesGATA4

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 DNA-binding transcription activator activity
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001947 heart looping
GO:0003162 atrioventricular node development
GO:0003180 aortic valve morphogenesis
GO:0003190 atrioventricular valve formation
GO:0003197 endocardial cushion development
GO:0003208 cardiac ventricle morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003281 ventricular septum development
GO:0003289 atrial septum primum morphogenesis
GO:0003290 atrial septum secundum morphogenesis
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007267 cell-cell signaling
GO:0007492 endoderm development
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0010507 negative regulation of autophagy
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0016604 nuclear body
GO:0019901 protein kinase binding
GO:0030513 positive regulation of BMP signaling pathway
GO:0033189 response to vitamin A
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0036302 atrioventricular canal development
GO:0042060 wound healing
GO:0042493 response to drug
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048617 embryonic foregut morphogenesis
GO:0051525 NFAT protein binding
GO:0051891 positive regulation of cardioblast differentiation
GO:0051896 regulation of protein kinase B signaling
GO:0060290 transdifferentiation
GO:0060413 atrial septum morphogenesis
GO:0060575 intestinal epithelial cell differentiation
GO:0061026 cardiac muscle tissue regeneration
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070410 co-SMAD binding
GO:0071333 cellular response to glucose stimulus
GO:0086004 regulation of cardiac muscle cell contraction
GO:0090575 RNA polymerase II transcription regulator complex
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1990837 sequence-specific double-stranded DNA binding
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000679 Zinc finger, GATA-typeDomainDomain
IPR008013 GATA-type transcription activator, N-terminalDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR016375 Transcription factor GATA-4/5/6FamilyFamily
IPR039355 Transcription factor GATAFamilyFamily

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
GATA4_HUMANNKX25_HUMANBioGRID, HPRD, IntAct10075728 10948187 12845333 15542826 9312027 details
GATA4_HUMANALX4_HUMANBioGRID, IntAct20211142 details
GATA4_HUMANZBTB3_HUMANIntAct20211142 details
GATA4_HUMANMDC1_HUMANBioGRID14578343 details
GATA4_HUMANHAND2_HUMANBioGRID, HPRD11994297 details
GATA4_HUMANSTF1_HUMANBioGRID, HPRD10446911 details
GATA4_HUMANFOG2_HUMANBioGRID, HPRD10801815 11297508 18252717 9927675 details
GATA4_HUMANSRF_HUMANBioGRID, HPRD11003651 11158291 details
GATA4_HUMANMK01_HUMANBioGRID11585926 details
GATA4_HUMANID1_HUMANBioGRID16556596 details
GATA4_HUMANID2_HUMANBioGRID16556596 details
GATA4_HUMANID3_HUMANBioGRID16556596 details
GATA4_HUMANEP300_HUMANBioGRID, HPRD11481322 18252717 27208796 details
GATA4_HUMANSP1_HUMANBioGRID14988427 21184844 details
GATA4_HUMANJARD2_HUMANBioGRID, HPRD15542826 22215809 details
GATA4_HUMANRACK1_HUMANBioGRID27208796 details
GATA4_HUMANNFAC4_HUMANHPRD9568714 details
GATA4_HUMANKLF13_HUMANMINT17053787 details
GATA4_HUMANEZH2_HUMANBioGRID, IntAct22094255 22215809 details
GATA4_HUMANTBX5_HUMANBioGRID, HPRD12845333 details
GATA4_HUMANHDAC2_HUMANBioGRID20833366 details
GATA4_HUMANEZH1_HUMANBioGRID22215809 details
GATA4_HUMANSUZ12_HUMANBioGRID22215809 details
GATA4_HUMANKDM6A_HUMANBioGRID22192413 details
GATA4_HUMANMEF2C_HUMANHPRD10790371 details
GATA4_HUMANCRIP2_HUMANHPRD12530967 details
GATA4_HUMANMK03_HUMANHPRD11585926 details
GATA4_HUMANMED1_HUMANHPRD11724781 details
GATA4_HUMANPIAS1_HUMANHPRD15337742 details
GATA4_HUMANFOS_HUMANHPRD9207128 details