Entity Details

Primary name CRKL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46109
EntryNameCRKL_HUMAN
FullNameCrk-like protein
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCRKL

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001558 regulation of cell growth
GO:0001568 blood vessel development
GO:0001655 urogenital system development
GO:0001764 neuron migration
GO:0001783 B cell apoptotic process
GO:0001784 phosphotyrosine residue binding
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003151 outflow tract morphogenesis
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0007254 JNK cascade
GO:0007265 Ras protein signal transduction
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007416 synapse assembly
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008584 male gonad development
GO:0009952 anterior/posterior pattern specification
GO:0010629 negative regulation of gene expression
GO:0016358 dendrite development
GO:0019221 cytokine-mediated signaling pathway
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030010 establishment of cell polarity
GO:0031594 neuromuscular junction
GO:0032991 protein-containing complex
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035556 intracellular signal transduction
GO:0035685 helper T cell diapedesis
GO:0035690 cellular response to drug
GO:0038026 reelin-mediated signaling pathway
GO:0042802 identical protein binding
GO:0045296 cadherin binding
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048384 retinoic acid receptor signaling pathway
GO:0048538 thymus development
GO:0050773 regulation of dendrite development
GO:0050852 T cell receptor signaling pathway
GO:0060017 parathyroid gland development
GO:0060326 cell chemotaxis
GO:0060465 pharynx development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0086100 endothelin receptor signaling pathway
GO:0090630 activation of GTPase activity
GO:0095500 acetylcholine receptor signaling pathway
GO:0098749 cerebellar neuron development
GO:0098761 cellular response to interleukin-7
GO:0098890 extrinsic component of postsynaptic membrane
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1903977 positive regulation of glial cell migration
GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering
GO:1904888 cranial skeletal system development
GO:2000404 regulation of T cell migration

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR035457 CRK, N-terminal SH3 domainDomainDomain
IPR035458 CRK, C-terminal SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

101 interactions

InteractorPartnerSourcesPublicationsLink
CRKL_HUMANCBL_HUMANBioGRID, HPRD, IntAct, MINT10204582 10608804 10657627 10907644 11133830 11157475 11263968 11399323 11553620 12244174 14604282 15107835 15358160 15556646 16503409 16982329 18835194 24886428 25814554 7545163 8524328 8621483 8626543 8662998 8978305 9092574 9129019 9162067 9195915 9311917 9344843 9461587 9590251 9660791 9820532 9851874 9988765 details
CRKL_HUMANM4K1_HUMANBioGRID, HPRD, IntAct11279207 9788432 9891069 details
CRKL_HUMANM4K5_HUMANBioGRID, HPRD, IntAct10648385 9788432 details
CRKL_HUMANINSR_HUMANHPRD, IntAct15522217 details
CRKL_HUMANEGFR_HUMANBioGRID, IntAct, MINT16729043 18271526 23397142 24658140 25402006 25754235 31980649 details
CRKL_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
CRKL_HUMANERBB3_HUMANBioGRID, MINT16273093 details
CRKL_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT11418612 16135792 16982329 23397142 32203420 9461587 details
CRKL_HUMANRPGF1_HUMANBioGRID, HPRD, IntAct, MINT10608804 10753869 10907644 11167825 11466412 16443220 18835194 26496610 30480076 8621483 8978305 9129019 9311917 9344843 9374471 9820532 details
CRKL_HUMANABL1_HUMANBioGRID, DIP, HPRD, IntAct, MINT14604282 16443220 16955467 18835194 19823681 22286129 24412932 7493940 7926767 8524328 8978305 9710592 9820532 details
CRKL_HUMANMSL1_HUMANBioGRID, IntAct18654987 details
CRKL_HUMANPKHA1_HUMANBioGRID, IntAct18654987 details
CRKL_HUMANGRN_HUMANBioGRID, IntAct, UniProt18654987 26370502 details
CRKL_HUMANPLS1_HUMANBioGRID, IntAct18654987 details
CRKL_HUMANLAMA5_HUMANBioGRID, IntAct18654987 details
CRKL_HUMANNOTC2_HUMANBioGRID, IntAct18654987 details
CRKL_HUMANMEGF6_HUMANBioGRID, IntAct18654987 details
CRKL_HUMANABI1_HUMANMINT20598684 details
CRKL_HUMANCBLB_HUMANBioGRID, HPRD, IntAct, MINT10022120 25814554 details
CRKL_HUMANPAXI_HUMANBioGRID, HPRD, MINT11463817 7493940 8978305 details
CRKL_HUMANSTA5A_HUMANBioGRID, HPRD, MINT11167825 9657743 9837784 details
CRKL_HUMANPGFRA_HUMANBioGRID, HPRD, IntAct, MINT25241761 9546424 details
CRKL_HUMANBIK_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANTYY1_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANRL31_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANRPAC2_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANAOXA_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANARHG5_HUMANBioGRID, IntAct21988832 32203420 details
CRKL_HUMANPHC2_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANLIPB2_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANKHDR1_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANTNS2_HUMANBioGRID, IntAct21988832 25814554 28675297 details
CRKL_HUMANWAC_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANGARE1_HUMANBioGRID, IntAct21988832 details
CRKL_HUMANSHAN3_HUMANIntAct21988832 details
CRKL_HUMANGAB1_HUMANBioGRID, HPRD, IntAct10753869 10871282 23397142 24728074 25241761 30480076 31585087 details
CRKL_HUMANIGF1R_HUMANBioGRID, HPRD, IntAct15522217 25241761 details
CRKL_HUMANPTN11_HUMANBioGRID, HPRD, IntAct23397142 9344843 9660791 details
CRKL_HUMANBCAR1_HUMANBioGRID, HPRD, MINT10753828 18835194 22974441 23770091 8810278 8978305 9498705 details
CRKL_HUMANTM168_HUMANBioGRID, IntAct25814554 details
CRKL_HUMANDOK2_HUMANBioGRID, IntAct25814554 details
CRKL_HUMANDOK1_HUMANBioGRID, HPRD, IntAct11071635 11553620 25814554 9822717 details
CRKL_HUMANSOCS1_HUMANBioGRID, IntAct25814554 29991678 details
CRKL_HUMANAREL1_HUMANBioGRID, IntAct25814554 details
CRKL_HUMANRIN3_HUMANBioGRID, IntAct25814554 32552912 details
CRKL_HUMANUBP53_HUMANBioGRID, IntAct32296183 details
CRKL_HUMANPTPC1_HUMANBioGRID, IntAct32296183 details
CRKL_HUMANPRS10_HUMANBioGRID, IntAct32296183 details
CRKL_HUMANBLK_HUMANBioGRID, IntAct32296183 details
CRKL_HUMANYES_HUMANBioGRID, IntAct32296183 details
CRKL_HUMANCRKL_HUMANDIP17161365 19168626 details
CRKL_HUMANGPVI_HUMANDIP19940238 details
CRKL_HUMANFLT3_HUMANMINT28086240 details
CRKL_HUMANBCR_HUMANBioGRID, HPRD10194128 15143164 8978305 details
CRKL_HUMANCASL_HUMANBioGRID, HPRD9020138 9162067 9405482 9498705 9820532 details
CRKL_HUMANKIT_HUMANBioGRID, HPRD11071635 9092574 details
CRKL_HUMANKSYK_HUMANBioGRID, HPRD11313252 details
CRKL_HUMANWASP_HUMANBioGRID, HPRD11313252 details
CRKL_HUMANRHG32_HUMANBioGRID, HPRD12446789 details
CRKL_HUMANCD34_HUMANBioGRID, HPRD11389015 details
CRKL_HUMANIRS4_HUMANBioGRID, HPRD9614078 details
CRKL_HUMANP85B_HUMANBioGRID, HPRD11553620 9092574 details
CRKL_HUMANEPOR_HUMANBioGRID, HPRD11443118 9129019 9344843 details
CRKL_HUMANSHIP1_HUMANBioGRID, HPRD11443118 details
CRKL_HUMANGAB2_HUMANBioGRID, HPRD10871282 11334882 9660791 details
CRKL_HUMANLTBP4_HUMANBioGRID18654987 details
CRKL_HUMANRPC22_HUMANBioGRID21988832 details
CRKL_HUMANSASH1_HUMANBioGRID30480076 details
CRKL_HUMANDAB1_HUMANBioGRID, HPRD15062102 15110774 details
CRKL_HUMANKDIS_HUMANBioGRID, HPRD15167895 16284401 details
CRKL_HUMANERBB4_HUMANMINT16729043 details
CRKL_HUMANMK08_HUMANMINT16982329 details
CRKL_HUMANFAK1_HUMANIntAct23397142 details
CRKL_HUMANSOS1_HUMANBioGRID, HPRD, IntAct23397142 26496610 32203420 9162067 details
CRKL_HUMANMK01_HUMANIntAct23397142 details
CRKL_HUMANRAF1_HUMANIntAct23397142 details
CRKL_HUMANVGFR1_HUMANIntAct23397142 details
CRKL_HUMANHCK_HUMANIntAct23397142 details
CRKL_HUMANPGFRB_HUMANIntAct23397142 details
CRKL_HUMANDCBD2_HUMANMINT23770091 details
CRKL_HUMANMARF1_HUMANBioGRID, IntAct26496610 29395067 details
CRKL_HUMANITB1_HUMANDIP19168626 details
CRKL_HUMANETV6_HUMANBioGRID, HPRD15143164 details
CRKL_HUMANFCGR1_HUMANBioGRID, HPRD9820532 details
CRKL_HUMANTYK2_HUMANBioGRID, HPRD9374471 details
CRKL_HUMANBLNK_HUMANBioGRID, HPRD11489945 details
CRKL_HUMANGRB2_HUMANBioGRID, HPRD10477741 details
CRKL_HUMANSHC1_HUMANBioGRID, HPRD9344843 details
CRKL_HUMANDOCK2_HUMANBioGRID, HPRD12393632 details
CRKL_HUMANPTEN_HUMANBioGRID15717329 details
CRKL_HUMANACK1_HUMANBioGRID28739485 details
CRKL_HUMANFGFR1_HUMANBioGRID19307307 details
CRKL_HUMANINAR1_HUMANHPRD11167825 details
CRKL_HUMANTGFI1_HUMANHPRD11463817 9858471 details
CRKL_HUMANEVL_HUMANHPRD10945997 details
CRKL_HUMANEPHB6_HUMANHPRD11466354 details
CRKL_HUMANLYN_HUMANHPRD11443118 details
CRKL_HUMANSOS2_HUMANHPRD8943292 details
CRKL_HUMANWIPF1_HUMANHPRD12504004 details
CRKL_HUMANSTA5B_HUMANHPRD10720694 11097834 9845531 details
CRKL_HUMANCRK_HUMANHPRD9614078 details