Entity Details

Primary name GCST_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48728
EntryNameGCST_HUMAN
FullNameAminomethyltransferase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length403
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesAMT

GO terms

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GOName
GO:0004047 aminomethyltransferase activity
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006546 glycine catabolic process
GO:0008483 transaminase activity
GO:0019464 glycine decarboxylation via glycine cleavage system

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR006222 Aminomethyltransferase, folate-binding domainDomainDomain
IPR006223 Glycine cleavage system T proteinFamilyFamily
IPR013977 Glycine cleavage T-protein, C-terminal barrel domainDomainDomain
IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1FamilyHomologous superfamily
IPR028896 Aminomethyltransferase-likeFamilyFamily
IPR029043 Glycine cleavage T-protein/YgfZ, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB04789 5-methyltetrahydrofolic acidDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GCST_HUMANPDLI4_HUMANBioGRID, IntAct32296183 details
GCST_HUMANVAC14_HUMANBioGRID, IntAct32296183 details
GCST_HUMANHSP7C_HUMANBioGRID25036637 details