Entity Details

Primary name PSN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49768
EntryNamePSN1_HUMAN
FullNamePresenilin-1
TaxID9606
Evidenceevidence at protein level
Length467
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPSEN1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000186 obsolete activation of MAPKK activity
GO:0000776 kinetochore
GO:0001568 blood vessel development
GO:0001708 cell fate specification
GO:0001756 somitogenesis
GO:0001764 neuron migration
GO:0001921 positive regulation of receptor recycling
GO:0001947 heart looping
GO:0002038 positive regulation of L-glutamate import across plasma membrane
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002265 astrocyte activation involved in immune response
GO:0002286 T cell activation involved in immune response
GO:0003407 neural retina development
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005262 calcium channel activity
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0006486 protein glycosylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006816 calcium ion transport
GO:0006839 mitochondrial transport
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007220 Notch receptor processing
GO:0007611 learning or memory
GO:0007613 memory
GO:0008013 beta-catenin binding
GO:0008021 synaptic vesicle
GO:0009791 post-embryonic development
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010975 regulation of neuron projection development
GO:0015031 protein transport
GO:0015871 choline transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016080 synaptic vesicle targeting
GO:0016235 aggresome
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0021549 cerebellum development
GO:0021795 cerebral cortex cell migration
GO:0021870 Cajal-Retzius cell differentiation
GO:0021904 dorsal/ventral neural tube patterning
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030165 PDZ domain binding
GO:0030326 embryonic limb morphogenesis
GO:0030426 growth cone
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031594 neuromuscular junction
GO:0031901 early endosome membrane
GO:0031965 nuclear membrane
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034205 amyloid-beta formation
GO:0035253 ciliary rootlet
GO:0035333 Notch receptor processing, ligand-dependent
GO:0035556 intracellular signal transduction
GO:0035577 azurophil granule membrane
GO:0042307 positive regulation of protein import into nucleus
GO:0042325 regulation of phosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0042383 sarcolemma
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043005 neuron projection
GO:0043011 myeloid dendritic cell differentiation
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043198 dendritic shaft
GO:0043312 neutrophil degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043589 skin morphogenesis
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045821 positive regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048013 ephrin receptor signaling pathway
GO:0048143 astrocyte activation
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048538 thymus development
GO:0048666 neuron development
GO:0048705 skeletal system morphogenesis
GO:0048854 brain morphogenesis
GO:0050435 amyloid-beta metabolic process
GO:0050673 epithelial cell proliferation
GO:0050771 negative regulation of axonogenesis
GO:0050808 synapse organization
GO:0050820 positive regulation of coagulation
GO:0050852 T cell receptor signaling pathway
GO:0051117 ATPase binding
GO:0051208 sequestering of calcium ion
GO:0051402 neuron apoptotic process
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060075 regulation of resting membrane potential
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060999 positive regulation of dendritic spine development
GO:0070765 gamma-secretase complex
GO:0070851 growth factor receptor binding
GO:0090647 modulation of age-related behavioral decline
GO:0098609 cell-cell adhesion
GO:0098712 L-glutamate import across plasma membrane
GO:0099056 integral component of presynaptic membrane
GO:1904646 cellular response to amyloid-beta
GO:1904797 negative regulation of core promoter binding
GO:1905908 positive regulation of amyloid fibril formation
GO:1990535 neuron projection maintenance
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasmic granule
Early endosome
Early endosome membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR001108 Peptidase A22A, presenilinFamilyFamily
IPR002031 Peptidase A22A, presenilin 1FamilyFamily
IPR006639 Presenilin/signal peptide peptidaseFamilyFamily
IPR042524 Presenilin, C-terminalFamilyHomologous superfamily

Diseases

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Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
PSN1_HUMANFLNB_HUMANBioGRID, HPRD, MINT9437013 details
PSN1_HUMANFLNA_HUMANHPRD, MINT9437013 details
PSN1_HUMANB2CL1_HUMANBioGRID, HPRD, MINT10446169 details
PSN1_HUMANUBQL1_HUMANBioGRID, HPRD, MINT11076969 16813565 16815845 details
PSN1_HUMANPKP4_HUMANBioGRID, HPRD, MINT10037471 10092585 details
PSN1_HUMANAPBA1_HUMANHPRD, IntAct, MINT11083918 12196555 16007100 details
PSN1_HUMANGSK3B_HUMANBioGRID, HPRD, MINT10997338 11104755 11193155 16814287 17360711 details
PSN1_HUMANNICA_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10993067 12297508 12471034 12603837 14572442 15257293 15474363 16641999 17911105 18201567 18667537 28351972 29611543 30559186 details
PSN1_HUMANA4_HUMANBioGRID, DIP, HPRD, IntAct10593990 11083918 21115843 21163940 23209290 28351972 32814053 9223340 details
PSN1_HUMANECSIT_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANF10A1_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANCDC37_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANGCDH_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANE41L3_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANACTN1_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANEFHD1_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANG3P_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANRMD3_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANENSA_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANCOF1_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANUMPS_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANSCOT1_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANCDK5_HUMANBioGRID, HPRD, IntAct12056836 21163940 details
PSN1_HUMANKANK2_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANPRAM_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANRAB3A_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANPSN2_HUMANBioGRID, IntAct12471034 15474363 21163940 details
PSN1_HUMANAPOE_HUMANBioGRID, IntAct21163940 details
PSN1_HUMANTYDP2_HUMANBioGRID, IntAct21988832 details
PSN1_HUMANHTRA2_HUMANIntAct10971580 details
PSN1_HUMANSOAT_HUMANBioGRID, IntAct32296183 details
PSN1_HUMANPEN2_HUMANBioGRID, HPRD, IntAct, UniProt12198112 12639958 14572442 15322109 15474363 21115843 22074918 30559186 32296183 details
PSN1_HUMANAPBA2_HUMANUniProt29578633 details
PSN1_HUMANPSB1_HUMANBioGRID, UniProt10527805 25959826 details
PSN1_HUMANPSA5_HUMANBioGRID, UniProt10527805 25959826 details
PSN1_HUMANPSN1_HUMANBioGRID, HPRD, UniProt12535650 15474363 25959826 9452432 details
PSN1_HUMANBI1_HUMANUniProt30559186 details
PSN1_HUMANBACE1_HUMANHPRD, UniProt12901838 details
PSN1_HUMANFMR1_HUMANIntAct32814053 details
PSN1_HUMANRN112_HUMANIntAct32814053 details
PSN1_HUMANAP2B1_HUMANIntAct32814053 details
PSN1_HUMANH31_HUMANIntAct32814053 details
PSN1_HUMANHYAL2_HUMANIntAct32814053 details
PSN1_HUMANPLPP1_HUMANIntAct32814053 details
PSN1_HUMANPLK1_HUMANIntAct32814053 details
PSN1_HUMANTR11B_HUMANIntAct32814053 details
PSN1_HUMANFRIL_HUMANIntAct32814053 details
PSN1_HUMANCBPE_HUMANIntAct32814053 details
PSN1_HUMANRN111_HUMANIntAct32814053 details
PSN1_HUMANOOSP2_HUMANIntAct32814053 details
PSN1_HUMANZMAT2_HUMANIntAct32814053 details
PSN1_HUMANSGSM1_HUMANIntAct32814053 details
PSN1_HUMANMOFA1_HUMANIntAct32814053 details
PSN1_HUMANLDH6B_HUMANIntAct32814053 details
PSN1_HUMANHUMMR_HUMANIntAct32814053 details
PSN1_HUMANKRA92_HUMANIntAct32814053 details
PSN1_HUMANWDR61_HUMANIntAct32814053 details
PSN1_HUMANDCR1B_HUMANIntAct32814053 details
PSN1_HUMANKBTB4_HUMANIntAct32814053 details
PSN1_HUMANOTUB1_HUMANIntAct32814053 details
PSN1_HUMANDALD3_HUMANIntAct32814053 details
PSN1_HUMANSPAG8_HUMANIntAct32814053 details
PSN1_HUMANRYBP_HUMANIntAct32814053 details
PSN1_HUMANPDZ1I_HUMANIntAct32814053 details
PSN1_HUMANIQEC1_HUMANIntAct32814053 details
PSN1_HUMANFEZ2_HUMANIntAct32814053 details
PSN1_HUMANCTNB1_HUMANBioGRID, HPRD10092585 10341227 11168528 11193155 11226248 12070348 16126725 16306047 17360711 9738936 9852041 details
PSN1_HUMANGFAP_HUMANBioGRID, HPRD12058025 details
PSN1_HUMANICAM5_HUMANBioGRID, HPRD11719200 details
PSN1_HUMANBCL2_HUMANBioGRID, HPRD10521466 15905180 details
PSN1_HUMANNOTC1_HUMANBioGRID, HPRD10077672 10206645 12374741 28351972 details
PSN1_HUMANCTND1_HUMANBioGRID, HPRD10208590 11226248 28069439 details
PSN1_HUMANKCIP4_HUMANBioGRID11847232 details
PSN1_HUMANCIB1_HUMANBioGRID, HPRD10366599 details
PSN1_HUMANYMEL1_HUMANBioGRID, HPRD12214059 details
PSN1_HUMANAP1M2_HUMANBioGRID21163940 details
PSN1_HUMANCP2CI_HUMANBioGRID21163940 details
PSN1_HUMANCP2C8_HUMANBioGRID21163940 details
PSN1_HUMANFXL12_HUMANBioGRID21163940 details
PSN1_HUMANNOS3_HUMANBioGRID21163940 details
PSN1_HUMANPDCD4_HUMANBioGRID21163940 details
PSN1_HUMANPRDX2_HUMANBioGRID21163940 details
PSN1_HUMANRD23A_HUMANBioGRID21163940 details
PSN1_HUMANRHEB_HUMANBioGRID21163940 details
PSN1_HUMANSTALP_HUMANBioGRID21163940 details
PSN1_HUMANRNF32_HUMANBioGRID21163940 details
PSN1_HUMANFGF13_HUMANBioGRID21163940 details
PSN1_HUMANHMGB1_HUMANBioGRID21163940 details
PSN1_HUMANITSN2_HUMANBioGRID21163940 details
PSN1_HUMANSCN1A_HUMANBioGRID21163940 details
PSN1_HUMANTBA1B_HUMANBioGRID21163940 details
PSN1_HUMANETFA_HUMANBioGRID10527805 details
PSN1_HUMANRYR2_HUMANBioGRID24029002 details
PSN1_HUMANMK09_HUMANBioGRID18667537 details
PSN1_HUMANFKBP8_HUMANBioGRID15905180 details
PSN1_HUMANPLAK_HUMANBioGRID, HPRD11226248 16306047 19114997 details
PSN1_HUMANRB11A_HUMANHPRD10369872 details
PSN1_HUMANCTND2_HUMANHPRD10037471 10208590 9223106 details
PSN1_HUMANMET2B_HUMANHPRD11738826 details
PSN1_HUMANDOCK3_HUMANHPRD10854253 details
PSN1_HUMANMTCH1_HUMANHPRD, IntAct10551805 12377771 details
PSN1_HUMANCADH1_HUMANBioGRID, MINT10635315 11953314 16126725 19114997 details
PSN1_HUMANTMEDA_HUMANBioGRID, IntAct, UniProt16641999 25959826 details
PSN1_HUMANAPH1A_HUMANBioGRID, DIP, HPRD, UniProt12297508 12471034 14572442 15474363 17911105 18667537 26280335 30559186 details
PSN1_HUMANTREM2_HUMANUniProt29611543 details
PSN1_HUMANERLN2_HUMANBioGRID, UniProt22771797 25959826 details
PSN1_HUMANFLOT2_HUMANUniProt25893612 details
PSN1_HUMANSTXB1_HUMANUniProt25893612 details
PSN1_HUMANNEUM_HUMANUniProt25893612 details
PSN1_HUMANGTR3_HUMANUniProt25893612 details
PSN1_HUMANMYCT_HUMANUniProt25893612 details
PSN1_HUMANATP9A_HUMANUniProt25893612 details
PSN1_HUMANHCN2_HUMANUniProt25893612 details
PSN1_HUMANNDUS7_HUMANUniProt25893612 details
PSN1_HUMANCNTP1_HUMANUniProt25893612 details
PSN1_HUMANCSTN1_HUMANBioGRID15037614 details
PSN1_HUMANCSEN_HUMANBioGRID, HPRD10854253 12207970 9771752 details
PSN1_HUMANFBXW7_HUMANBioGRID, HPRD12354302 details
PSN1_HUMANCTNA1_HUMANBioGRID, HPRD10635315 details
PSN1_HUMANTF7L2_HUMANBioGRID11504726 details
PSN1_HUMANHERP1_HUMANBioGRID, HPRD11799129 14550564 details
PSN1_HUMANERN1_HUMANBioGRID, HPRD10587643 details
PSN1_HUMANTAU_HUMANBioGRID, HPRD9689133 details
PSN1_HUMANTRAF6_HUMANBioGRID18996842 19012753 23707529 24399296 details
PSN1_HUMANIRAK2_HUMANBioGRID18996842 details
PSN1_HUMANAPH1B_HUMANBioGRID, HPRD12471034 15474363 details
PSN1_HUMANTGFR1_HUMANBioGRID24399296 details
PSN1_HUMANUBC_HUMANBioGRID24399296 25959826 details
PSN1_HUMANGSAP_HUMANBioGRID20811458 details
PSN1_HUMANPE2R4_HUMANBioGRID19407341 details
PSN1_HUMANCADH2_HUMANBioGRID20696212 details
PSN1_HUMANNOTC4_HUMANHPRD11518718 details
PSN1_HUMANNOTC2_HUMANHPRD11518718 details
PSN1_HUMANNOTC3_HUMANHPRD11518718 details
PSN1_HUMANCASP4_HUMANHPRD10069390 details
PSN1_HUMANEFNB2_HUMANHPRD16511561 details
PSN1_HUMANCASP1_HUMANHPRD10069390 details
PSN1_HUMANP85A_HUMANHPRD15192701 details
PSN1_HUMANKPCZ_HUMANHPRD14576165 details
PSN1_HUMANGDIA_HUMANHPRD15480879 details
PSN1_HUMANCASP3_HUMANHPRD10069390 details
PSN1_HUMANCASP6_HUMANHPRD10069390 details
PSN1_HUMANKAPCA_HUMANHPRD14576165 details
PSN1_HUMANCASP7_HUMANHPRD10069390 details
PSN1_HUMANCASP8_HUMANHPRD10069390 details
PSN1_HUMANSCAFB_HUMANHPRD10069390 details
PSN1_HUMANDLL1_HUMANHPRD12794186 details