Entity Details

Primary name PSN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49810
EntryNamePSN2_HUMAN
FullNamePresenilin-2
TaxID9606
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPSEN2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0004175 endopeptidase activity
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0006509 membrane protein ectodomain proteolysis
GO:0006816 calcium ion transport
GO:0007220 Notch receptor processing
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0030018 Z disc
GO:0030426 growth cone
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031594 neuromuscular junction
GO:0032991 protein-containing complex
GO:0034205 amyloid-beta formation
GO:0035253 ciliary rootlet
GO:0035333 Notch receptor processing, ligand-dependent
GO:0035556 intracellular signal transduction
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043198 dendritic shaft
GO:0045121 membrane raft
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050435 amyloid-beta metabolic process
GO:0070765 gamma-secretase complex
GO:0110097 regulation of calcium import into the mitochondrion
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR001108 Peptidase A22A, presenilinFamilyFamily
IPR001493 Peptidase A22A, presenilin 2FamilyFamily
IPR006639 Presenilin/signal peptide peptidaseFamilyFamily
IPR042524 Presenilin, C-terminalFamilyHomologous superfamily

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
PSN2_HUMANFHL2_HUMANBioGRID, HPRD, MINT11001931 details
PSN2_HUMANFLNB_HUMANBioGRID, HPRD, MINT9437013 details
PSN2_HUMANFLNA_HUMANHPRD, MINT9437013 details
PSN2_HUMANB2CL1_HUMANBioGRID, HPRD, MINT10446169 details
PSN2_HUMANSORCN_HUMANBioGRID, HPRD, MINT10748169 details
PSN2_HUMANUBQL1_HUMANBioGRID, HPRD, MINT11076969 16813565 17614368 details
PSN2_HUMANCIB1_HUMANBioGRID, HPRD, MINT10366599 details
PSN2_HUMANA4_HUMANBioGRID, HPRD, IntAct10078972 21163940 32814053 9223340 details
PSN2_HUMANECSIT_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANPDCD4_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANDYHC1_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANEID1_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANMAST1_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANPSN1_HUMANBioGRID, IntAct12471034 15474363 21163940 details
PSN2_HUMANRNF32_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANLIPG_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANDNJB1_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANEXOC6_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANFXL12_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANRHEB_HUMANBioGRID, IntAct21163940 details
PSN2_HUMANDMB_HUMANBioGRID, IntAct29997244 details
PSN2_HUMANNEBL_HUMANIntAct32814053 details
PSN2_HUMANPDZ1I_HUMANIntAct32814053 details
PSN2_HUMANMICA2_HUMANIntAct32814053 details
PSN2_HUMANSOX14_HUMANIntAct32814053 details
PSN2_HUMANH31_HUMANIntAct32814053 details
PSN2_HUMANS6A13_HUMANIntAct32814053 details
PSN2_HUMANRING2_HUMANIntAct32814053 details
PSN2_HUMANP85A_HUMANIntAct32814053 details
PSN2_HUMANMNDA_HUMANIntAct32814053 details
PSN2_HUMANFRIL_HUMANIntAct32814053 details
PSN2_HUMANCASP1_HUMANHPRD, IntAct10069390 32814053 9219695 9990034 details
PSN2_HUMANBAK_HUMANIntAct32814053 details
PSN2_HUMANKAD2_HUMANIntAct32814053 details
PSN2_HUMANUBAC1_HUMANIntAct32814053 details
PSN2_HUMANELL2_HUMANIntAct32814053 details
PSN2_HUMANRYBP_HUMANIntAct32814053 details
PSN2_HUMANSP6_HUMANIntAct32814053 details
PSN2_HUMANWDR61_HUMANIntAct32814053 details
PSN2_HUMANFX4L6_HUMANIntAct32814053 details
PSN2_HUMANARL16_HUMANIntAct32814053 details
PSN2_HUMANZSCA1_HUMANIntAct32814053 details
PSN2_HUMANZN366_HUMANIntAct32814053 details
PSN2_HUMANZMAT2_HUMANIntAct32814053 details
PSN2_HUMANSGSM1_HUMANIntAct32814053 details
PSN2_HUMANMR1L1_HUMANIntAct32814053 details
PSN2_HUMANHNRLL_HUMANIntAct32814053 details
PSN2_HUMANHUMMR_HUMANIntAct32814053 details
PSN2_HUMANZXDC_HUMANIntAct32814053 details
PSN2_HUMANCAN1_HUMANBioGRID, HPRD10677567 9852298 details
PSN2_HUMANCSEN_HUMANBioGRID, HPRD11278424 9771752 details
PSN2_HUMANGFAP_HUMANBioGRID12058025 details
PSN2_HUMANICAM5_HUMANBioGRID, HPRD11719200 details
PSN2_HUMANKCIP4_HUMANBioGRID, HPRD11847232 details
PSN2_HUMANNOS3_HUMANBioGRID21163940 details
PSN2_HUMANCEP55_HUMANBioGRID21163940 details
PSN2_HUMANELAV1_HUMANBioGRID21163940 details
PSN2_HUMANEVI5L_HUMANBioGRID21163940 details
PSN2_HUMANGCDH_HUMANBioGRID21163940 details
PSN2_HUMANIFIT3_HUMANBioGRID21163940 details
PSN2_HUMANIFIT5_HUMANBioGRID21163940 details
PSN2_HUMANOGA_HUMANBioGRID21163940 details
PSN2_HUMANSPC24_HUMANBioGRID21163940 details
PSN2_HUMANAAMP_HUMANBioGRID21163940 details
PSN2_HUMANACTG_HUMANBioGRID21163940 details
PSN2_HUMANCHKA_HUMANBioGRID21163940 details
PSN2_HUMANECD_HUMANBioGRID21163940 details
PSN2_HUMANHPS1_HUMANBioGRID21163940 details
PSN2_HUMANAP1G1_HUMANBioGRID27293189 details
PSN2_HUMANKC1A_HUMANBioGRID, HPRD27293189 8972483 details
PSN2_HUMANCSK21_HUMANBioGRID, HPRD27293189 8972483 9558331 9990034 details
PSN2_HUMANAURKA_HUMANBioGRID27293189 details
PSN2_HUMANRB11A_HUMANHPRD10369872 details
PSN2_HUMANMET2B_HUMANHPRD11738826 details
PSN2_HUMANDOCK3_HUMANHPRD10854253 details
PSN2_HUMANBI1_HUMANUniProt30559186 details
PSN2_HUMANAPBA1_HUMANBioGRID12196555 details
PSN2_HUMANAPBA2_HUMANBioGRID12196555 details
PSN2_HUMANAPBA3_HUMANBioGRID12196555 details
PSN2_HUMANAPH1A_HUMANBioGRID, HPRD12297508 12471034 15474363 details
PSN2_HUMANNICA_HUMANBioGRID, HPRD10993067 12297508 15474363 details
PSN2_HUMANPEN2_HUMANBioGRID, HPRD12198112 12639958 15474363 22074918 details
PSN2_HUMANTRAF6_HUMANBioGRID18996842 23707529 details
PSN2_HUMANPSN2_HUMANBioGRID15474363 details
PSN2_HUMANAPH1B_HUMANBioGRID, HPRD12297508 15474363 details
PSN2_HUMANFKBP8_HUMANBioGRID15905180 details
PSN2_HUMANBCL2_HUMANBioGRID15905180 details
PSN2_HUMANCASP3_HUMANHPRD10069390 9219695 9990034 details
PSN2_HUMANKC1D_HUMANHPRD8972483 9558331 9990034 details
PSN2_HUMANCASP6_HUMANHPRD10069390 9219695 9990034 details
PSN2_HUMANCASP7_HUMANHPRD10069390 9219695 9990034 details
PSN2_HUMANCASP8_HUMANHPRD10069390 9219695 9990034 details
PSN2_HUMANCFLAR_HUMANHPRD10069390 9219695 9990034 details
PSN2_HUMANCTND2_HUMANHPRD10037471 details
PSN2_HUMANCTNB1_HUMANHPRD10037471 details
PSN2_HUMANNOTC4_HUMANHPRD11518718 details
PSN2_HUMANNOTC1_HUMANHPRD11518718 details
PSN2_HUMANNOTC2_HUMANHPRD11518718 details
PSN2_HUMANNOTC3_HUMANHPRD11518718 details