Entity Details

Primary name SPHM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51688
EntryNameSPHM_HUMAN
FullNameN-sulphoglucosamine sulphohydrolase
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSGSH

GO terms

Show/Hide Table
GOName
GO:0005539 glycosaminoglycan binding
GO:0005764 lysosome
GO:0006027 glycosaminoglycan catabolic process
GO:0008449 N-acetylglucosamine-6-sulfatase activity
GO:0016250 N-sulfoglucosamine sulfohydrolase activity
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0043202 lysosomal lumen
GO:0046872 metal ion binding
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Lysosome

Domains

Show/Hide Table
DomainNameCategoryType
IPR000917 Sulfatase, N-terminalDomainDomain
IPR017850 Alkaline-phosphatase-like, core domain superfamilyFamilyHomologous superfamily
IPR024607 Sulfatase, conserved siteSiteConserved site
IPR032506 Domain of unknown function DUF4976DomainDomain

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SPHM_HUMANPCNA_HUMANUniProt26030842 details
SPHM_HUMANOGT1_HUMANBioGRID32994395 details