Entity Details

Primary name CACB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54284
EntryNameCACB3_HUMAN
FullNameVoltage-dependent L-type calcium channel subunit beta-3
TaxID9606
Evidenceevidence at protein level
Length484
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCACNB3

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005246 calcium channel regulator activity
GO:0005829 cytosol
GO:0005891 voltage-gated calcium channel complex
GO:0006816 calcium ion transport
GO:0007268 chemical synaptic transmission
GO:0007528 neuromuscular junction development
GO:0008331 high voltage-gated calcium channel activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019901 protein kinase binding
GO:0045202 synapse
GO:0050852 T cell receptor signaling pathway
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051899 membrane depolarization
GO:0060402 calcium ion transport into cytosol
GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0072659 protein localization to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0098903 regulation of membrane repolarization during action potential
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:1901843 positive regulation of high voltage-gated calcium channel activity
GO:1902630 regulation of membrane hyperpolarization
GO:1905788 negative regulation of detection of mechanical stimulus involved in sensory perception of touch
GO:1990454 L-type voltage-gated calcium channel complex
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000584 Voltage-dependent calcium channel, L-type, beta subunitFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR008079 Voltage-dependent calcium channel, L-type, beta-3 subunitFamilyFamily
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035760 Voltage-dependent L-type calcium channel subunit beta-3, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00653 Magnesium sulfateDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09232 CilnidipineDrugbanksmall molecule
DB09236 LacidipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule