Entity Details

Primary name UBP14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54578
EntryNameUBP14_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase 14
TaxID9606
Evidenceevidence at protein level
Length494
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesUSP14

GO terms

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GOName
GO:0000502 proteasome complex
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0004866 endopeptidase inhibitor activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016579 protein deubiquitination
GO:0031410 cytoplasmic vesicle
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response
GO:0050920 regulation of chemotaxis
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070062 extracellular exosome
GO:0070628 proteasome binding
GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR019954 Ubiquitin conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR044635 Ubiquitin carboxyl-terminal hydrolase 14-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
UBP14_HUMANCSN5_HUMANBioGRID, IntAct18624398 31950832 details
UBP14_HUMANUB2V2_HUMANIntAct19549727 details
UBP14_HUMANPSMD2_HUMANBioGRID, IntAct19615732 24951540 28539385 29581427 29777785 30425250 31740976 31901637 details
UBP14_HUMANSEM1_HUMANBioGRID, MINT24811749 28396413 details
UBP14_HUMANFANCC_HUMANBioGRID14499622 details
UBP14_HUMANCXCR4_HUMANBioGRID19106094 details
UBP14_HUMANERN1_HUMANBioGRID19135427 24951540 details
UBP14_HUMANUBP21_HUMANBioGRID22626734 details
UBP14_HUMANUBP15_HUMANBioGRID22626734 29581427 30425250 31740976 details
UBP14_HUMANUBP28_HUMANBioGRID22626734 details
UBP14_HUMANUBC_HUMANBioGRID23287719 23801757 27066941 28190767 29576527 details
UBP14_HUMANSEML_HUMANBioGRID24811749 28396413 details
UBP14_HUMANCCNB1_HUMANBioGRID27074503 31474315 details
UBP14_HUMANTRI14_HUMANBioGRID29053956 details
UBP14_HUMANTRI11_HUMANBioGRID29581427 details
UBP14_HUMANXRCC6_HUMANBioGRID30425250 30585729 31740976 details
UBP14_HUMANATF2_HUMANBioGRID31964530 details
UBP14_HUMANOGT1_HUMANBioGRID32994395 details
UBP14_HUMANHLAB_HUMANIntAct17353931 details
UBP14_HUMANPP2BA_HUMANMINT19896943 details
UBP14_HUMANPRS8_HUMANBioGRID, IntAct17646385 19615732 26344197 30425250 31901637 details
UBP14_HUMANPSMD4_HUMANBioGRID, IntAct19349277 19615732 30425250 31740976 31901637 details
UBP14_HUMANPACN1_HUMANIntAct31413325 details
UBP14_HUMANRD23A_HUMANBioGRID19013454 details
UBP14_HUMANPSA2_HUMANBioGRID19193609 30425250 31901637 details
UBP14_HUMANRNF11_HUMANBioGRID23751493 details
UBP14_HUMANHD_HUMANBioGRID24951540 details
UBP14_HUMANB2CL1_HUMANBioGRID25429837 26710889 details
UBP14_HUMANGABR1_HUMANBioGRID26817839 details
UBP14_HUMANVIME_HUMANBioGRID27448976 31272261 details
UBP14_HUMANDERL1_HUMANBioGRID28137758 details
UBP14_HUMANANDR_HUMANBioGRID28151478 29353883 details
UBP14_HUMANAURKB_HUMANBioGRID28662510 30425250 details
UBP14_HUMANCBP_HUMANBioGRID28611184 31594848 details
UBP14_HUMANSQSTM_HUMANBioGRID29995557 32292717 details
UBP14_HUMANMLP3B_HUMANBioGRID29995557 details
UBP14_HUMANRN168_HUMANBioGRID29995557 details
UBP14_HUMANBECN1_HUMANBioGRID29326710 31272261 details
UBP14_HUMANTRAF6_HUMANBioGRID29326710 32820146 details
UBP14_HUMANTAB2_HUMANBioGRID29326710 details
UBP14_HUMANPSB2_HUMANBioGRID30425250 32723828 details
UBP14_HUMANDDX58_HUMANBioGRID30466171 details
UBP14_HUMANSFI1_HUMANBioGRID31197030 details
UBP14_HUMANHSP7C_HUMANBioGRID31901637 details
UBP14_HUMANGBRAP_HUMANBioGRID31901637 details
UBP14_HUMANSPAG5_HUMANBioGRID31957155 details
UBP14_HUMANBCL6_HUMANBioGRID32033748 details
UBP14_HUMANMDM2_HUMANBioGRID33061808 details
UBP14_HUMANVGFR2_HUMANBioGRID32908134 details