Entity Details

Primary name NR1H2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55055
EntryNameNR1H2_HUMAN
FullNameOxysterols receptor LXR-beta
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNR1H2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010884 positive regulation of lipid storage
GO:0010887 negative regulation of cholesterol storage
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0031667 response to nutrient levels
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032376 positive regulation of cholesterol transport
GO:0034191 apolipoprotein A-I receptor binding
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0042632 cholesterol homeostasis
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048550 negative regulation of pinocytosis
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0051117 ATPase binding
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0090108 positive regulation of high-density lipoprotein particle assembly
GO:0090187 positive regulation of pancreatic juice secretion
GO:0090340 positive regulation of secretion of lysosomal enzymes
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1903573 negative regulation of response to endoplasmic reticulum stress

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR023257 Liver X receptorFamilyFamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB03791 GW-3965Drugbanksmall molecule
DB03848 Benzenesulfinic acidDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07082 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OLDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB13174 RheinDrugbanksmall molecule

Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
NR1H2_HUMANMDFI_HUMANBioGRID, HPRD, IntAct16189514 19060904 25416956 32296183 details
NR1H2_HUMANCIDEA_HUMANMolecular Connections21315073 details
NR1H2_HUMANCDN1A_HUMANBioGRID, IntAct21988832 details
NR1H2_HUMANTYY1_HUMANBioGRID, IntAct21988832 details
NR1H2_HUMANLAMC3_HUMANBioGRID, IntAct21988832 details
NR1H2_HUMANNPY_HUMANBioGRID, IntAct15604093 21988832 32296183 details
NR1H2_HUMANDUS12_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANCREL2_HUMANMINT21900206 details
NR1H2_HUMANERG28_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANCHD3_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANCO4A5_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANCSAD_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANFAF1_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANHMGX4_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANEM55_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANRMI1_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANROBO2_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANRXRG_HUMANBioGRID, HPRD, IntAct, MINT15604093 20211142 21900206 25416956 25910212 28514442 31515488 32296183 details
NR1H2_HUMANASM_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANSRBS2_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANUB2D1_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANVIME_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANSPY2_HUMANBioGRID, MINT21900206 details
NR1H2_HUMANSUV91_HUMANBioGRID, MINT23455924 details
NR1H2_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
NR1H2_HUMANMED1_HUMANBioGRID, HPRD, IntAct15604093 26120082 details
NR1H2_HUMANNCOR1_HUMANBioGRID, HPRD, IntAct12663743 15604093 26120082 details
NR1H2_HUMANCOR2A_HUMANBioGRID, DIP21331046 details
NR1H2_HUMANKCC2G_HUMANDIP21331046 details
NR1H2_HUMANRXRA_HUMANBioGRID, DIP, HPRD, IntAct15604093 15722453 20211142 24561505 7760852 details
NR1H2_HUMANPPARD_HUMANBioGRID, DIP15722453 details
NR1H2_HUMANPPARA_HUMANBioGRID, DIP15722453 details
NR1H2_HUMANPPARG_HUMANBioGRID, DIP15722453 details
NR1H2_HUMANRXRB_HUMANBioGRID, HPRD, IntAct10187832 15604093 20211142 32296183 details
NR1H2_HUMANNCOA6_HUMANBioGRID, HPRD11158331 12724417 15604093 details
NR1H2_HUMANNR0B2_HUMANBioGRID, HPRD12198243 27485016 details
NR1H2_HUMANHDAC4_HUMANBioGRID17218271 details
NR1H2_HUMANZXDC_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANNRIP1_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANNCOR2_HUMANBioGRID, HPRD15604093 16219912 details
NR1H2_HUMANNCOA3_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANRARA_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANFOXO3_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMAN7B2_HUMANBioGRID15604093 details
NR1H2_HUMANUBC9_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANT161A_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANING3_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANPCD17_HUMANBioGRID15604093 details
NR1H2_HUMANVDR_HUMANBioGRID, HPRD15604093 details
NR1H2_HUMANBAG6_HUMANBioGRID21900206 details
NR1H2_HUMANKPCA_HUMANBioGRID18372238 details
NR1H2_HUMANACVL1_HUMANBioGRID12393874 details
NR1H2_HUMANNCOA1_HUMANBioGRID15604093 details
NR1H2_HUMANRHOU_HUMANBioGRID26598620 details
NR1H2_HUMANDNM3L_HUMANBioGRID24952347 details
NR1H2_HUMANABCA1_HUMANbhf-ucl, BioGRID20951680 23931754 25838426 details
NR1H2_HUMANMEN1_HUMANMINT25962847 details
NR1H2_HUMANSENP3_HUMANBioGRID, DIP21331046 details
NR1H2_HUMANSIR1_HUMANBioGRID, HPRD17936707 details
NR1H2_HUMANSMCA4_HUMANBioGRID15774904 details
NR1H2_HUMANPIAS1_HUMANBioGRID22969086 27485016 details
NR1H2_HUMANPRGC2_HUMANBioGRID22969086 details
NR1H2_HUMANSTAT1_HUMANBioGRID27485016 details
NR1H2_HUMANNR1H2_HUMANHPRD12819202 details