Entity Details

Primary name NAC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP57103
EntryNameNAC3_HUMAN
FullNameSodium/calcium exchanger 3
TaxID9606
Evidenceevidence at protein level
Length927
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSLC8A3

GO terms

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GOName
GO:0002244 hematopoietic progenitor cell differentiation
GO:0005432 calcium:sodium antiporter activity
GO:0005516 calmodulin binding
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006851 mitochondrial calcium ion transmembrane transport
GO:0006874 cellular calcium ion homeostasis
GO:0007154 cell communication
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0014069 postsynaptic density
GO:0014819 regulation of skeletal muscle contraction
GO:0015491 cation:cation antiporter activity
GO:0016020 membrane
GO:0016528 sarcoplasm
GO:0021537 telencephalon development
GO:0030001 metal ion transport
GO:0030424 axon
GO:0030425 dendrite
GO:0031226 intrinsic component of plasma membrane
GO:0031594 neuromuscular junction
GO:0035725 sodium ion transmembrane transport
GO:0042383 sarcolemma
GO:0042552 myelination
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0045202 synapse
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0050808 synapse organization
GO:0051560 mitochondrial calcium ion homeostasis
GO:0060291 long-term synaptic potentiation
GO:0070588 calcium ion transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071456 cellular response to hypoxia
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0098703 calcium ion import across plasma membrane
GO:0098794 postsynapse
GO:0098815 modulation of excitatory postsynaptic potential
GO:0099055 integral component of postsynaptic membrane
GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential
GO:1903779 regulation of cardiac conduction
GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1990034 calcium ion export across plasma membrane

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Endoplasmic reticulum membrane
Mitochondrion outer membrane
Perikaryon

Domains

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DomainNameCategoryType
IPR003644 Na-Ca exchanger/integrin-beta4DomainDomain
IPR004836 Sodium/calcium exchanger proteinFamilyFamily
IPR004837 Sodium/calcium exchanger membrane regionDomainDomain
IPR032452 Sodium/calcium exchanger domain, C-terminal extensionDomainDomain
IPR038081 CalX-like domain superfamilyFamilyHomologous superfamily

Diseases

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