Entity Details

Primary name PRS10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62333
EntryNamePRS10_HUMAN
FullName26S proteasome regulatory subunit 10B
TaxID9606
Evidenceevidence at protein level
Length389
SequenceStatuscomplete
DateCreated2004-07-05
DateModified2021-06-02

Ontological Relatives

GenesPSMC6

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016579 protein deubiquitination
GO:0016887 ATP hydrolysis activity
GO:0022624 proteasome accessory complex
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030674 protein-macromolecule adaptor activity
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031597 cytosolic proteasome complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0036402 proteasome-activating activity
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR005937 26S proteasome regulatory subunit P45-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032501 Proteasomal ATPase OB C-terminal domainDomainDomain
IPR035263 26S proteasome regulatory subunit 10BFamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

Show/Hide Table

Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
PRS10_HUMANPRS6A_HUMANBioGRID, DIP, IntAct19490896 22275368 22863883 22939629 25416956 26186194 26344197 27342858 28292943 28514442 29636472 32296183 details
PRS10_HUMANPRS10_HUMANBioGRID, HPRD, IntAct15782218 16501559 25416956 28292943 32296183 details
PRS10_HUMANPSA6_HUMANBioGRID, DIP22939629 26344197 27342858 28292943 29636472 details
PRS10_HUMANNMDE3_HUMANIntAct32814053 details
PRS10_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
PRS10_HUMANPRS8_HUMANBioGRID, DIP, IntAct, MINT11361004 16763564 19490896 22275368 22863883 22939629 26344197 27342858 28292943 28514442 29636472 32296183 details
PRS10_HUMANPSD13_HUMANBioGRID, DIP, IntAct17353931 22863883 22939629 26344197 28292943 29636472 details
PRS10_HUMANPRS7_HUMANBioGRID, DIP, IntAct19490896 22863883 22901813 22939629 26344197 27342858 28292943 29636472 9464850 details
PRS10_HUMANCC146_HUMANBioGRID, IntAct25416956 details
PRS10_HUMANUBC_HUMANBioGRID16196087 28190767 details
PRS10_HUMANCRK_HUMANBioGRID, HPRD, IntAct16189514 26871637 32296183 details
PRS10_HUMANPSMD9_HUMANBioGRID, HPRD, IntAct, MINT16189514 19490896 21516116 24720748 25416956 26186194 26344197 28514442 31515488 32296183 details
PRS10_HUMANS14L5_HUMANBioGRID, IntAct32296183 details
PRS10_HUMANPRS6B_HUMANBioGRID, DIP, IntAct19490896 22275368 22939629 26344197 27342858 28292943 28514442 29636472 details
PRS10_HUMANTF2AA_HUMANBioGRID, IntAct32296183 details
PRS10_HUMANPSD12_HUMANBioGRID, DIP, I2D, IntAct20890303 22863883 22939629 26344197 28292943 28514442 29636472 details
PRS10_HUMANCDC37_HUMANBioGRID, IntAct32296183 details
PRS10_HUMANFGFR3_HUMANIntAct32814053 details
PRS10_HUMANHSPB1_HUMANIntAct32814053 details
PRS10_HUMANSDCB1_HUMANBioGRID, IntAct25416956 32296183 details
PRS10_HUMANTCPB_HUMANBioGRID23190606 details
PRS10_HUMANWFS1_HUMANIntAct32814053 details
PRS10_HUMANUBC9_HUMANBioGRID32296183 details
PRS10_HUMANCA216_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
PRS10_HUMANNB5R2_HUMANBioGRID, IntAct25416956 details
PRS10_HUMANCRKL_HUMANBioGRID, IntAct32296183 details
PRS10_HUMANSMCE1_HUMANBioGRID, IntAct32296183 details
PRS10_HUMANBYST_HUMANBioGRID, IntAct32296183 details
PRS10_HUMANCDC42_HUMANBioGRID31478661 details
PRS10_HUMANPRS4_HUMANBioGRID, DIP, IntAct19490896 22863883 22939629 26186194 26344197 26496610 27342858 28514442 29636472 details
PRS10_HUMANPSMD8_HUMANBioGRID, DIP22275368 22863883 22939629 26344197 29636472 details
PRS10_HUMANMDM2_HUMANBioGRID20479273 details
PRS10_HUMANPSDE_HUMANBioGRID, DIP, IntAct17323924 19412159 22863883 22939629 26344197 26496610 27428775 28821611 29636472 details
PRS10_HUMANFKBP8_HUMANBioGRID17573772 details
PRS10_HUMANPSMD6_HUMANBioGRID, DIP, IntAct17353931 22275368 22939629 26344197 29636472 details
PRS10_HUMANSEML_HUMANBioGRID15610744 16239144 details
PRS10_HUMANPSMD4_HUMANBioGRID, DIP, MINT16990800 22863883 22939629 26344197 29636472 30479383 details
PRS10_HUMANPSA2_HUMANBioGRID, DIP19193609 26344197 27342858 29636472 details
PRS10_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PRS10_HUMANPMS2_HUMANBioGRID17148452 details
PRS10_HUMANPAAF1_HUMANBioGRID, HPRD, IntAct15831487 17353931 details
PRS10_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRS10_HUMANATX7_HUMANBioGRID11734547 details
PRS10_HUMANJKAMP_HUMANBioGRID19269966 details
PRS10_HUMANSEM1_HUMANBioGRID15610744 16239144 details
PRS10_HUMANSIR6_HUMANBioGRID24169447 details
PRS10_HUMANTRM7_HUMANIntAct17353931 details
PRS10_HUMANPSME4_HUMANDIP18845680 details
PRS10_HUMANTRI18_HUMANBioGRID26748699 details
PRS10_HUMANHDAC5_HUMANBioGRID21081666 details
PRS10_HUMANIKKE_HUMANIntAct17353931 details
PRS10_HUMANTRAF6_HUMANIntAct14743216 details
PRS10_HUMANHLAB_HUMANIntAct17353931 details
PRS10_HUMANSIAH1_HUMANBioGRID20479273 details
PRS10_HUMANDISC1_HUMANIntAct31413325 details