Entity Details

Primary name PHEX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78562
EntryNamePHEX_HUMAN
FullNamePhosphate-regulating neutral endopeptidase PHEX
TaxID9606
Evidenceevidence at protein level
Length749
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPHEX

GO terms

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GOName
GO:0001501 skeletal system development
GO:0004222 metalloendopeptidase activity
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0016485 protein processing
GO:0019637 organophosphate metabolic process
GO:0030282 bone mineralization
GO:0030324 lung development
GO:0042476 odontogenesis
GO:0048471 perinuclear region of cytoplasm
GO:0060348 bone development
GO:0060416 response to growth hormone
GO:0071305 cellular response to vitamin D
GO:0071374 cellular response to parathyroid hormone stimulus
GO:1904383 response to sodium phosphate
GO:1990418 response to insulin-like growth factor stimulus

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000718 Peptidase M13FamilyFamily
IPR008753 Peptidase M13, N-terminal domainDomainDomain
IPR018497 Peptidase M13, C-terminal domainDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR042089 Peptidase M13, domain 2FamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PHEX_HUMANMEPE_HUMANUniProt15664000 details
PHEX_HUMANFGF23_HUMANHPRD11409890 details