Entity Details

Primary name PGBM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98160
EntryNamePGBM_HUMAN
FullNameBasement membrane-specific heparan sulfate proteoglycan core protein
TaxID9606
Evidenceevidence at protein level
Length4391
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesHSPG2

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001525 angiogenesis
GO:0001540 amyloid-beta binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006027 glycosaminoglycan catabolic process
GO:0006629 lipid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006954 inflammatory response
GO:0007420 brain development
GO:0008022 protein C-terminus binding
GO:0009887 animal organ morphogenesis
GO:0009888 tissue development
GO:0016525 negative regulation of angiogenesis
GO:0030021 extracellular matrix structural constituent conferring compression resistance
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0043202 lysosomal lumen
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060548 negative regulation of cell death
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072359 circulatory system development
GO:0098797 plasma membrane protein complex
GO:1905907 negative regulation of amyloid fibril formation
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000034 Laminin IVDomainDomain
IPR000082 SEA domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002049 Laminin EGF domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00039 PaliferminDrugbankbiotech

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
PGBM_HUMANGRN_HUMANHPRD, MINT12900424 details
PGBM_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
PGBM_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
PGBM_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
PGBM_HUMANTELT_HUMANBioGRID, IntAct23414517 details
PGBM_HUMANFINC_HUMANBioGRID, IntAct11493006 19738201 details
PGBM_HUMANVGFR2_HUMANmatrixdb, MINT21596751 23374253 details
PGBM_HUMANVGFR1_HUMANmatrixdb21596751 details
PGBM_HUMANFGF7_HUMANBioGRID, HPRD10702276 details
PGBM_HUMANTTHY_HUMANBioGRID, HPRD9307034 details
PGBM_HUMANPRELP_HUMANBioGRID, HPRD11847210 details
PGBM_HUMANFGFP1_HUMANBioGRID, HPRD11148217 details
PGBM_HUMANNID2_HUMANBioGRID, HPRD11493006 9733643 details
PGBM_HUMANFBLN2_HUMANBioGRID, HPRD11493006 7500359 9431988 details
PGBM_HUMANLAMA1_HUMANBioGRID, HPRD9688542 details
PGBM_HUMANPDGFA_HUMANBioGRID, HPRD9692901 details
PGBM_HUMANPDGFB_HUMANBioGRID, HPRD9692901 details
PGBM_HUMANUBC_HUMANBioGRID28190767 details
PGBM_HUMANHS90A_HUMANBioGRID31273033 details
PGBM_HUMANECM1_HUMANHPRD12604605 details
PGBM_HUMANPR40A_HUMANHPRD15231748 details
PGBM_HUMANMCAF1_HUMANHPRD15231748 details
PGBM_HUMANFGF2_HUMANHPRD, matrixdb11847221 24509440 details
PGBM_HUMANITA2_HUMANHPRD15240572 details
PGBM_HUMANCCN2_HUMANHPRD12811819 details
PGBM_HUMANBMP1_HUMANHPRD15591058 details
PGBM_HUMANFBN1_HUMANHPRD15657057 details
PGBM_HUMANVWA1_HUMANHPRD16407285 details
PGBM_HUMANNID1_HUMANHPRD11493006 11574465 details
PGBM_HUMANFBLN1_HUMANHPRD7500359 details
PGBM_HUMANSPRC_HUMANHPRD2745554 details
PGBM_HUMANA4_HUMANHPRD9136074 details