Entity Details

Primary name MMSA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02252
EntryNameMMSA_HUMAN
FullNameMethylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
TaxID9606
Evidenceevidence at protein level
Length535
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesALDH6A1

GO terms

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GOName
GO:0000062 fatty-acyl-CoA binding
GO:0003723 RNA binding
GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006210 thymine catabolic process
GO:0006573 valine metabolic process
GO:0006574 valine catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0018478 malonate-semialdehyde dehydrogenase (acetylating) activity
GO:0019859 thymine metabolic process
GO:0050873 brown fat cell differentiation
GO:0102662 malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR010061 Methylmalonate-semialdehyde dehydrogenaseFamilyFamily
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MMSA_HUMANRBTN2_HUMANBioGRID, IntAct21988832 details
MMSA_HUMANOGT1_HUMANBioGRID32994395 details