Entity Details

Primary name KPCZ_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05513
EntryNameKPCZ_HUMAN
FullNameProtein kinase C zeta type
TaxID9606
Evidenceevidence at protein level
Length592
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCZ

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0001725 stress fiber
GO:0001954 positive regulation of cell-matrix adhesion
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007616 long-term memory
GO:0008284 positive regulation of cell population proliferation
GO:0014069 postsynaptic density
GO:0015459 potassium channel regulator activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016363 nuclear matrix
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030010 establishment of cell polarity
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031584 activation of phospholipase D activity
GO:0031982 vesicle
GO:0032148 activation of protein kinase B activity
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0035748 myelin sheath abaxonal region
GO:0043066 negative regulation of apoptotic process
GO:0043203 axon hillock
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045179 apical cortex
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0047496 vesicle transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051222 positive regulation of protein transport
GO:0051346 negative regulation of hydrolase activity
GO:0051899 membrane depolarization
GO:0060081 membrane hyperpolarization
GO:0060291 long-term synaptic potentiation
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0071889 14-3-3 protein binding
GO:0072659 protein localization to plasma membrane
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990138 neuron projection extension
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Endosome
Membrane

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012233 Protein kinase CFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR034662 Atypical Protein Kinase C zeta, catalytic domainDomainDomain
IPR034877 Protein kinase C, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule

Interactions

121 interactions

InteractorPartnerSourcesPublicationsLink
KPCZ_HUMANPAR6A_HUMANBioGRID, HPRD, IntAct, MINT11260256 12813044 14676191 15254234 16189514 17057644 17335965 17350623 25852190 27143478 28514442 details
KPCZ_HUMANPAR6B_HUMANBioGRID, HPRD, IntAct11260256 12887891 14676191 25852190 26186194 27107012 28514442 29491746 31980649 32296183 details
KPCZ_HUMANPAR6G_HUMANBioGRID, HPRD, IntAct, MINT11260256 14676191 17057644 25852190 28514442 31980649 details
KPCZ_HUMANTF65_HUMANBioGRID, HPRD, MINT11684013 12881425 21131967 details
KPCZ_HUMANNUMB_HUMANBioGRID, HPRD, MINT17203073 details
KPCZ_HUMANKPCT_HUMANIntAct17588663 details
KPCZ_HUMANAKT1_HUMANBioGRID, HPRD, MINT10085094 11723139 14560023 18353613 18650932 details
KPCZ_HUMANGBRAP_HUMANBioGRID, IntAct20562859 31857374 details
KPCZ_HUMANHS90A_HUMANBioGRID, IntAct20936779 22939624 29491746 details
KPCZ_HUMANCC115_HUMANBioGRID, MINT21900206 details
KPCZ_HUMANDEN5A_HUMANBioGRID, MINT21900206 details
KPCZ_HUMANNMT2_HUMANBioGRID, MINT21900206 details
KPCZ_HUMANUT14A_HUMANBioGRID, MINT21900206 details
KPCZ_HUMAN1433B_HUMANBioGRID, HPRD, MINT10620507 21900206 details
KPCZ_HUMANZNF71_HUMANBioGRID, MINT21900206 details
KPCZ_HUMANC1QBP_HUMANBioGRID, HPRD, IntAct, UniProt10831594 23402259 25852190 29491746 31980649 details
KPCZ_HUMANAKT3_HUMANBioGRID, HPRD, IntAct12162751 25241761 9305920 9512493 details
KPCZ_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
KPCZ_HUMANSQSTM_HUMANBioGRID, HPRD, IntAct10356400 10747026 11755531 12813044 12887891 15143057 15870274 20974803 20979579 23023376 25852190 26187466 27143478 28514442 29491746 31980649 32354117 34079125 9566925 details
KPCZ_HUMANNCF1_HUMANBioGRID, HPRD, IntAct11145703 12056906 27040869 8089108 details
KPCZ_HUMANKIBRA_HUMANBioGRID, HPRD, IntAct15081397 28514442 31980649 details
KPCZ_HUMANPDPK1_HUMANBioGRID, HPRD10357815 10764742 11222751 11781095 14500673 9748166 details
KPCZ_HUMANADAP1_HUMANBioGRID, HPRD12893243 details
KPCZ_HUMAN1433Z_HUMANBioGRID10620507 12893243 29491746 details
KPCZ_HUMANNFAC2_HUMANBioGRID, HPRD12021260 details
KPCZ_HUMANDAPK3_HUMANBioGRID, HPRD12242277 details
KPCZ_HUMANNUCL_HUMANBioGRID, HPRD9388266 details
KPCZ_HUMAN1433T_HUMANBioGRID10620507 details
KPCZ_HUMANRAF1_HUMANBioGRID, HPRD10620507 details
KPCZ_HUMANTIAM1_HUMANBioGRID10212259 details
KPCZ_HUMANFEZ1_HUMANBioGRID, HPRD9971736 details
KPCZ_HUMANPAWR_HUMANBioGRID, HPRD11755531 8797824 details
KPCZ_HUMANMP2K5_HUMANBioGRID11158308 details
KPCZ_HUMANSP1_HUMANBioGRID16943418 18258854 details
KPCZ_HUMANCHIP_HUMANBioGRID21911421 details
KPCZ_HUMANPIAS4_HUMANBioGRID21624955 27162139 details
KPCZ_HUMANKPCZ_HUMANBioGRID, HPRD17639074 21624955 29491746 31980649 7588787 8375396 9748166 details
KPCZ_HUMANMBP_HUMANBioGRID, HPRD10383403 17639074 21315177 details
KPCZ_HUMANNCOA3_HUMANBioGRID18313384 details
KPCZ_HUMANLRRK2_HUMANBioGRID20949042 details
KPCZ_HUMANH11_HUMANBioGRID12056906 details
KPCZ_HUMANPP14A_HUMANBioGRID, HPRD15003508 details
KPCZ_HUMANMARCS_HUMANBioGRID7588787 details
KPCZ_HUMANH15_HUMANBioGRID8663071 details
KPCZ_HUMANMK07_HUMANBioGRID20538799 details
KPCZ_HUMANBIEA_HUMANBioGRID17639074 details
KPCZ_HUMANHDAC6_HUMANBioGRID25860570 details
KPCZ_HUMANTAU_HUMANBioGRID11104762 details
KPCZ_HUMANMLP3B_HUMANBioGRID31857374 details
KPCZ_HUMANFRS2_HUMANHPRD10383403 details
KPCZ_HUMANKPCI_HUMANBioGRID, IntAct, MINT11260256 24375676 25852190 28514442 29491746 31980649 details
KPCZ_HUMANJAM1_HUMANBioGRID, IntAct, MINT17057644 25241761 details
KPCZ_HUMANVHL_HUMANBioGRID, MINT10491320 17101696 17350623 details
KPCZ_HUMANHS90B_HUMANBioGRID, IntAct22939624 29491746 details
KPCZ_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct11481324 25241761 details
KPCZ_HUMANGRM5_HUMANBioGRID, HPRD, IntAct15894802 25241761 details
KPCZ_HUMANBCL10_HUMANIntAct25011391 details
KPCZ_HUMANTRI41_HUMANBioGRID, IntAct17893151 28514442 details
KPCZ_HUMANRAGE_HUMANIntAct21829704 details
KPCZ_HUMANNPM_HUMANBioGRID, IntAct23402259 29491746 31980649 details
KPCZ_HUMANCD44_HUMANBioGRID, IntAct22610405 31980649 details
KPCZ_HUMANCSK2B_HUMANBioGRID, HPRD, IntAct10764587 29491746 31980649 details
KPCZ_HUMANPARD3_HUMANBioGRID, IntAct12459187 31980649 details
KPCZ_HUMANECT2_HUMANBioGRID15254234 details
KPCZ_HUMANFEZ2_HUMANBioGRID, HPRD14697253 details
KPCZ_HUMANIRAK1_HUMANBioGRID, HPRD11937546 details
KPCZ_HUMANTRAF6_HUMANBioGRID, HPRD10747026 details
KPCZ_HUMANGRB14_HUMANBioGRID, HPRD12242277 details
KPCZ_HUMANK1C10_HUMANBioGRID, HPRD11585925 details
KPCZ_HUMANKS6B1_HUMANBioGRID16931574 details
KPCZ_HUMAN1433G_HUMANBioGRID10620507 details
KPCZ_HUMAN1433F_HUMANBioGRID10620507 details
KPCZ_HUMANFADD_HUMANBioGRID, HPRD11739185 details
KPCZ_HUMANSRC_HUMANBioGRID, HPRD10527887 details
KPCZ_HUMANMSH6_HUMANBioGRID15808853 details
KPCZ_HUMANMSH2_HUMANBioGRID15808853 details
KPCZ_HUMANTLR4_HUMANBioGRID21911421 details
KPCZ_HUMANTLR9_HUMANBioGRID21911421 details
KPCZ_HUMANESR1_HUMANBioGRID18313384 details
KPCZ_HUMANAJUBA_HUMANBioGRID15870274 details
KPCZ_HUMANCOF1_HUMANBioGRID23402259 29491746 details
KPCZ_HUMANAKT2_HUMANBioGRID18353613 details
KPCZ_HUMANABL1_HUMANBioGRID16631755 details
KPCZ_HUMANDP13A_HUMANBioGRID26583432 details
KPCZ_HUMANRN146_HUMANBioGRID27521426 details
KPCZ_HUMANPP2AA_HUMANBioGRID29491746 details
KPCZ_HUMANJAK1_HUMANBioGRID, HPRD15526032 29491746 details
KPCZ_HUMANKPCA_HUMANBioGRID, HPRD10339425 12162751 31980649 8856079 details
KPCZ_HUMANRIPK1_HUMANBioGRID32354117 details
KPCZ_HUMANUBP20_HUMANBioGRID32354117 details
KPCZ_HUMANKPCD_HUMANHPRD11381116 12162751 details
KPCZ_HUMANCASP3_HUMANHPRD11016947 details
KPCZ_HUMANIKKB_HUMANHPRD10022904 10195894 10779355 9689078 details
KPCZ_HUMANIRS4_HUMANHPRD12774026 details
KPCZ_HUMANPEBP1_HUMANHPRD12551925 14654844 details
KPCZ_HUMANADCY5_HUMANHPRD8206971 details
KPCZ_HUMANPRG2_HUMANHPRD10357815 11222751 14500673 9748166 details
KPCZ_HUMANAFAP1_HUMANHPRD12134071 details
KPCZ_HUMANPDLI7_HUMANHPRD8940095 details
KPCZ_HUMANHABP4_HUMANHPRD14699138 details
KPCZ_HUMANBTK_HUMANHPRD11788586 7522330 details
KPCZ_HUMANPP2BA_HUMANHPRD12021260 details
KPCZ_HUMANCDC42_HUMANHPRD10733591 details
KPCZ_HUMANGLRX3_HUMANHPRD10636891 details
KPCZ_HUMANCLAT_HUMANHPRD15381704 details
KPCZ_HUMANMK03_HUMANHPRD15721486 details
KPCZ_HUMANMK01_HUMANHPRD15721486 details
KPCZ_HUMANRASH_HUMANHPRD15721486 details
KPCZ_HUMANIL4RA_HUMANHPRD15526032 details
KPCZ_HUMANRHOA_HUMANHPRD15210811 details
KPCZ_HUMANMP2K1_HUMANHPRD11535599 details
KPCZ_HUMANSTAT6_HUMANHPRD15526032 details
KPCZ_HUMANGSK3A_HUMANHPRD11481324 details
KPCZ_HUMANFYN_HUMANHPRD8621384 details
KPCZ_HUMANCASP9_HUMANHPRD16287866 details
KPCZ_HUMANCASP6_HUMANHPRD11016947 details
KPCZ_HUMANCASP8_HUMANHPRD11016947 details
KPCZ_HUMANCASP7_HUMANHPRD11016947 details
KPCZ_HUMANS39A1_HUMANHPRD10477520 details
KPCZ_HUMANIRS1_HUMANHPRD11063744 details
KPCZ_HUMANPSN1_HUMANHPRD14576165 details