Entity Details

Primary name LRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07954
EntryNameLRP1_HUMAN
FullNameProlow-density lipoprotein receptor-related protein 1
TaxID9606
Evidenceevidence at protein level
Length4544
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesLRP1

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001540 amyloid-beta binding
GO:0002020 protease binding
GO:0002265 astrocyte activation involved in immune response
GO:0003723 RNA binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005044 scavenger receptor activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0006629 lipid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007041 lysosomal transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007568 aging
GO:0008283 cell population proliferation
GO:0010715 regulation of extracellular matrix disassembly
GO:0010875 positive regulation of cholesterol efflux
GO:0010942 positive regulation of cell death
GO:0010977 negative regulation of neuron projection development
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016964 alpha-2 macroglobulin receptor activity
GO:0021987 cerebral cortex development
GO:0030136 clathrin-coated vesicle
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030226 apolipoprotein receptor activity
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0031623 receptor internalization
GO:0032050 clathrin heavy chain binding
GO:0032092 positive regulation of protein binding
GO:0032370 positive regulation of lipid transport
GO:0032374 regulation of cholesterol transport
GO:0032429 regulation of phospholipase A2 activity
GO:0032593 insulin-responsive compartment
GO:0032956 regulation of actin cytoskeleton organization
GO:0034185 apolipoprotein binding
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035909 aorta morphogenesis
GO:0038023 signaling receptor activity
GO:0038024 cargo receptor activity
GO:0042157 lipoprotein metabolic process
GO:0042953 lipoprotein transport
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0043395 heparan sulfate proteoglycan binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044242 cellular lipid catabolic process
GO:0044295 axonal growth cone
GO:0044877 protein-containing complex binding
GO:0045056 transcytosis
GO:0045177 apical part of cell
GO:0045807 positive regulation of endocytosis
GO:0048691 positive regulation of axon extension involved in regeneration
GO:0048694 positive regulation of collateral sprouting of injured axon
GO:0050766 positive regulation of phagocytosis
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051895 negative regulation of focal adhesion assembly
GO:0061642 chemoattraction of axon
GO:0070325 lipoprotein particle receptor binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097242 amyloid-beta clearance
GO:0098797 plasma membrane protein complex
GO:0150093 amyloid-beta clearance by transcytosis
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:0150104 transport across blood-brain barrier
GO:1900149 positive regulation of Schwann cell migration
GO:1900223 positive regulation of amyloid-beta clearance
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1904109 positive regulation of cholesterol import
GO:1904300 positive regulation of transcytosis
GO:1904646 cellular response to amyloid-beta
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1905049 negative regulation of metallopeptidase activity
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi outpost
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR032485 Domain of unknown function DUF5050DomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB00100 Coagulation Factor IX (Recombinant)Drugbankbiotech
DB06245 LanoteplaseDrugbankbiotech
DB13152 Coagulation Factor IX HumanDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
LRP1_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
LRP1_HUMANFCN2_HUMANMINT21054788 details
LRP1_HUMANMBL2_HUMANMINT21054788 details
LRP1_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
LRP1_HUMANAPBB1_HUMANBioGRID, HPRD, MINT, UniProt21968187 24284412 9837937 details
LRP1_HUMANA4_HUMANBioGRID, HPRD, IntAct, MINT12212791 19251705 21968187 32814053 7543026 details
LRP1_HUMANAMRP_HUMANbhf-ucl, BioGRID, HPRD, IntAct, UniProt10747918 1374383 16101684 1718973 17326667 20030366 28514442 details
LRP1_HUMANHS90A_HUMANBioGRID, IntAct20558745 31273033 details
LRP1_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 28065597 31980649 details
LRP1_HUMANDLG4_HUMANBioGRID, DIP, HPRD10827173 17360663 details
LRP1_HUMANAPOE_HUMANBioGRID, HPRD, UniProt11421580 15182176 20030366 2779654 details
LRP1_HUMANALG3_HUMANUniProt29547901 details
LRP1_HUMANBLMH_HUMANIntAct32814053 details
LRP1_HUMANVPS29_HUMANIntAct32814053 details
LRP1_HUMANCHIP_HUMANIntAct32814053 details
LRP1_HUMANS100B_HUMANIntAct32814053 details
LRP1_HUMANKSYK_HUMANIntAct32814053 details
LRP1_HUMANKAT5_HUMANBioGRID, HPRD12888553 details
LRP1_HUMANCALCR_HUMANBioGRID12821648 details
LRP1_HUMANSHC1_HUMANBioGRID, HPRD11854294 12069755 12789267 details
LRP1_HUMANTSP1_HUMANBioGRID, HPRD14991768 7775583 9045712 details
LRP1_HUMANGIPC1_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANJIP1_HUMANBioGRID, HPRD10827173 20205790 details
LRP1_HUMANJIP2_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANSYJ2B_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANCAPON_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANSCN3A_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANAPBA2_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANDAB1_HUMANBioGRID, HPRD10827173 9837937 details
LRP1_HUMANITBP1_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANAPC10_HUMANBioGRID, HPRD10827173 details
LRP1_HUMANPDGFB_HUMANBioGRID, HPRD11854294 details
LRP1_HUMANSRC_HUMANBioGRID, HPRD11854294 12789267 details
LRP1_HUMANDAB2_HUMANBioGRID11247302 details
LRP1_HUMANFA8_HUMANBioGRID, HPRD12522143 details
LRP1_HUMANGULP1_HUMANBioGRID, HPRD11729193 details
LRP1_HUMANUPAR_HUMANBioGRID, HPRD11359936 details
LRP1_HUMANTPA_HUMANBioGRID, HPRD10632583 1502153 details
LRP1_HUMANFA9_HUMANBioGRID, HPRD12522212 details
LRP1_HUMANLIPL_HUMANBioGRID, HPRD1281473 7510694 7989348 details
LRP1_HUMANLIPC_HUMANBioGRID, HPRD7721852 details
LRP1_HUMANSNX17_HUMANBioGRID, HPRD12169628 details
LRP1_HUMANRIC8B_HUMANBioGRID20205790 details
LRP1_HUMANC2D1A_HUMANBioGRID20205790 details
LRP1_HUMANRU17_HUMANBioGRID20205790 details
LRP1_HUMANANS1B_HUMANBioGRID20205790 details
LRP1_HUMANPCLI1_HUMANBioGRID20205790 details
LRP1_HUMANHNRDL_HUMANBioGRID20205790 details
LRP1_HUMANMARE1_HUMANBioGRID20205790 details
LRP1_HUMANPTN11_HUMANBioGRID23922991 details
LRP1_HUMANNGF_HUMANBioGRID7537086 details
LRP1_HUMANNTF3_HUMANBioGRID7537086 details
LRP1_HUMANNTF4_HUMANBioGRID7537086 details
LRP1_HUMANBDNF_HUMANBioGRID7537086 details
LRP1_HUMANCLUS_HUMANBioGRID31273033 details
LRP1_HUMAN1433G_HUMANIntAct17353931 details
LRP1_HUMANNOTC3_HUMANI2D20472562 details
LRP1_HUMANNMDE1_HUMANDIP17360663 details
LRP1_HUMANPAI1_HUMANBioGRID, HPRD15001579 details
LRP1_HUMANCALX_HUMANBioGRID, HPRD14980518 details
LRP1_HUMANCALR_HUMANBioGRID, HPRD12821648 14980518 details
LRP1_HUMANPDIA2_HUMANBioGRID14980518 details
LRP1_HUMANMMP14_HUMANBioGRID, HPRD14645246 details
LRP1_HUMANA2MG_HUMANBioGRID, HPRD10652313 12194978 details
LRP1_HUMANMK_HUMANBioGRID, HPRD10772929 details
LRP1_HUMANCUBN_HUMANBioGRID17124247 details
LRP1_HUMANCHFR_HUMANBioGRID23241409 details
LRP1_HUMANRANB9_HUMANBioGRID19251705 details
LRP1_HUMANCSN5_HUMANBioGRID23926111 details
LRP1_HUMANKPCA_HUMANBioGRID17974965 details
LRP1_HUMANCO3_HUMANHPRD10608878 details
LRP1_HUMANC4BPA_HUMANHPRD11705989 details
LRP1_HUMANCCN2_HUMANHPRD14585398 details
LRP1_HUMANFURIN_HUMANHPRD2112085 8546712 details
LRP1_HUMANTRFL_HUMANHPRD1464627 details
LRP1_HUMANENPL_HUMANHPRD11861214 details
LRP1_HUMANMMP13_HUMANHPRD10514495 details
LRP1_HUMANKAPCA_HUMANHPRD11158305 details
LRP1_HUMANGTPB1_HUMANHPRD9820815 details
LRP1_HUMANMMP15_HUMANHPRD14645246 details
LRP1_HUMANMMP16_HUMANHPRD14645246 details
LRP1_HUMANMMP17_HUMANHPRD14645246 details
LRP1_HUMANCD82_HUMANHPRD9804823 details
LRP1_HUMANLRP1_HUMANHPRD8703036 details
LRP1_HUMANCAV1_HUMANHPRD14593097 details
LRP1_HUMANWNT3A_HUMANHPRD14739301 details
LRP1_HUMANBACE1_HUMANHPRD15749709 details
LRP1_HUMANA1AT_HUMANHPRD15131125 details
LRP1_HUMANCATG_HUMANHPRD15131125 details
LRP1_HUMANELNE_HUMANHPRD15131125 details