Entity Details

Primary name DPYD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12882
EntryNameDPYD_HUMAN
FullNameDihydropyrimidine dehydrogenase [NADP(+)]
TaxID9606
Evidenceevidence at protein level
Length1025
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDPYD

GO terms

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GOName
GO:0002058 uracil binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006145 purine nucleobase catabolic process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0006210 thymine catabolic process
GO:0006212 uracil catabolic process
GO:0006214 thymidine catabolic process
GO:0006248 CMP catabolic process
GO:0006249 dCMP catabolic process
GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity
GO:0019483 beta-alanine biosynthetic process
GO:0042803 protein homodimerization activity
GO:0046050 UMP catabolic process
GO:0046079 dUMP catabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR005720 Dihydroorotate dehydrogenase domainDomainDomain
IPR009051 Alpha-helical ferredoxinFamilyHomologous superfamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domainDomainDomain
IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved siteSiteConserved site
IPR023753 FAD/NAD(P)-binding domainDomainDomain
IPR028261 Dihydroprymidine dehydrogenase domain IIDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR044512 Dihydropyrimidine dehydrogenaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00544 FluorouracilDrugbanksmall molecule
DB01101 CapecitabineDrugbanksmall molecule
DB02303 (5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedioneDrugbanksmall molecule
DB02338 NADPHDrugbanksmall molecule
DB03048 6-CarboxymethyluracilDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB03419 UracilDrugbanksmall molecule
DB03516 EniluracilDrugbanksmall molecule
DB03554 5-IodouracilDrugbanksmall molecule
DB09257 GimeracilDrugbanksmall molecule
DB09327 Tegafur-uracilDrugbanksmall molecule

Interactions

4 interactions