Entity Details

Primary name PKD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13563
EntryNamePKD2_HUMAN
FullNamePolycystin-2
TaxID9606
Evidenceevidence at protein level
Length968
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPKD2

GO terms

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GOName
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0001947 heart looping
GO:0002133 polycystin complex
GO:0003127 detection of nodal flow
GO:0005102 signaling receptor binding
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005261 cation channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005929 cilium
GO:0006816 calcium ion transport
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0008092 cytoskeletal protein binding
GO:0008285 negative regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0010628 positive regulation of gene expression
GO:0015271 outward rectifier potassium channel activity
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016323 basolateral plasma membrane
GO:0021510 spinal cord development
GO:0021915 neural tube development
GO:0022843 voltage-gated cation channel activity
GO:0030027 lamellipodium
GO:0030659 cytoplasmic vesicle membrane
GO:0031514 motile cilium
GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0034614 cellular response to reactive oxygen species
GO:0034703 cation channel complex
GO:0035502 metanephric part of ureteric bud development
GO:0035725 sodium ion transmembrane transport
GO:0035904 aorta development
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042805 actinin binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043398 HLH domain binding
GO:0044325 transmembrane transporter binding
GO:0044782 cilium organization
GO:0045180 basal cortex
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048763 calcium-induced calcium release activity
GO:0050982 detection of mechanical stimulus
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051219 phosphoprotein binding
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051290 protein heterotetramerization
GO:0051298 centrosome duplication
GO:0051371 muscle alpha-actinin binding
GO:0060170 ciliary membrane
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060674 placenta blood vessel development
GO:0061333 renal tubule morphogenesis
GO:0061441 renal artery morphogenesis
GO:0070062 extracellular exosome
GO:0070588 calcium ion transmembrane transport
GO:0071277 cellular response to calcium ion
GO:0071320 cellular response to cAMP
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071464 cellular response to hydrostatic pressure
GO:0071470 cellular response to osmotic stress
GO:0071498 cellular response to fluid shear stress
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0071805 potassium ion transmembrane transport
GO:0071910 determination of liver left/right asymmetry
GO:0072075 metanephric mesenchyme development
GO:0072164 mesonephric tubule development
GO:0072177 mesonephric duct development
GO:0072208 metanephric smooth muscle tissue development
GO:0072214 metanephric cortex development
GO:0072218 metanephric ascending thin limb development
GO:0072219 metanephric cortical collecting duct development
GO:0072235 metanephric distal tubule development
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072686 mitotic spindle
GO:0090279 regulation of calcium ion import
GO:0097730 non-motile cilium
GO:0098662 inorganic cation transmembrane transport
GO:0198738 cell-cell signaling by wnt
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Cell membrane
Cell projection
Cytoplasmic vesicle membrane
Endoplasmic reticulum membrane
Golgi apparatus

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR003915 Polycystic kidney disease type 2 proteinFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013122 Polycystin cation channel, PKD1/PKD2DomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
PKD2_HUMANPKD1_HUMANbhf-ucl, BioGRID, DIP, HPRD, MINT10097141 11901144 19556541 20168298 21126580 21642537 30093605 9192675 details
PKD2_HUMANMAGA8_HUMANBioGRID, IntAct25416956 29892012 details
PKD2_HUMANACTN2_HUMANHPRD15843396 details
PKD2_HUMANPLS1_HUMANBioGRID, IntAct25416956 details
PKD2_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
PKD2_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
PKD2_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
PKD2_HUMANPKD2_HUMANBioGRID, DIP, HPRD, MINT19556541 20168298 21622852 27991905 28092368 9192675 details
PKD2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
PKD2_HUMANCD2AP_HUMANHPRD10913159 details
PKD2_HUMANKR108_HUMANBioGRID, IntAct25416956 details
PKD2_HUMANPTPRG_HUMANBioGRID21126580 details
PKD2_HUMANHAX1_HUMANbhf-ucl, HPRD10760273 details
PKD2_HUMANTRPC1_HUMANbhf-ucl, BioGRID, HPRD, IntAct10097141 25114176 details
PKD2_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
PKD2_HUMANLMNA_HUMANBioGRID24623722 details
PKD2_HUMANTPM1_HUMANHPRD12527301 details
PKD2_HUMANTNNI3_HUMANBioGRID, HPRD12525172 details
PKD2_HUMANID2_HUMANbhf-ucl16311606 details
PKD2_HUMANKR103_HUMANBioGRID25416956 details
PKD2_HUMANGCC2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PKD2_HUMANAT1A1_HUMANBioGRID11901144 details
PKD2_HUMANDIAP1_HUMANbhf-ucl, HPRD, MINT15123714 18388856 details
PKD2_HUMANPACS2_HUMANHPRD15692563 details
PKD2_HUMANCALX_HUMANBioGRID11901144 details
PKD2_HUMANAKT1_HUMANBioGRID24462114 details
PKD2_HUMANGOGA2_HUMANBioGRID11901144 details
PKD2_HUMANPACS1_HUMANHPRD15692563 details
PKD2_HUMANBAP31_HUMANMINT19153608 details