Entity Details

Primary name MTMR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13614
EntryNameMTMR2_HUMAN
FullNameMyotubularin-related protein 2
TaxID9606
Evidenceevidence at protein level
Length643
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMTMR2

GO terms

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GOName
GO:0002091 negative regulation of receptor internalization
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008021 synaptic vesicle
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0014069 postsynaptic density
GO:0030424 axon
GO:0030425 dendrite
GO:0031642 negative regulation of myelination
GO:0031901 early endosome membrane
GO:0032288 myelin assembly
GO:0042802 identical protein binding
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0045806 negative regulation of endocytosis
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0048666 neuron development
GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
GO:0060304 regulation of phosphatidylinositol dephosphorylation
GO:0070062 extracellular exosome
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0097060 synaptic membrane
GO:0097062 dendritic spine maintenance
GO:2000643 positive regulation of early endosome to late endosome transport
GO:2000645 negative regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Early endosome membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR004182 GRAM domainDomainDomain
IPR010569 Myotubularin-like phosphatase domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR030564 Myotubularin familyFamilyFamily

Diseases

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