Entity Details

Primary name BACE1
Entity type gene
Source Source Link

Details

PrimaryID23621
RefseqGeneNG_029372
SymbolBACE1
Namebeta-secretase 1
Chromosome11
Location11q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsBACE1_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0008021 synaptic vesicle
GO:0008233 peptidase activity
GO:0009314 response to radiation
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010288 response to lead ion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0034205 amyloid-beta formation
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043525 positive regulation of neuron apoptotic process
GO:0045121 membrane raft
GO:0050435 amyloid-beta metabolic process
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0055037 recycling endosome
GO:0060134 prepulse inhibition
GO:0070931 Golgi-associated vesicle lumen
GO:0071280 cellular response to copper ion
GO:0071287 cellular response to manganese ion
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:1904646 cellular response to amyloid-beta
GO:1990000 amyloid fibril formation
GO:2000300 regulation of synaptic vesicle exocytosis

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
BACE1APPBioGRID, HPRD, IntAct, UniProt10531052 10677483 12901838 16407538 19251705 22801501 28869759 30538620 31996371 32814053 details
BACE1ADRB2BioGRID, MINT28298427 details
BACE1KCNC4BioGRID, UniProt29507146 details
BACE1PDIA3HPRD, UniProt15606899 20354142 details
BACE1IAPPUniProt26840340 details
BACE1GGA1BioGRID, UniProt14567678 15117318 15466887 15886016 26053850 details
BACE1GGA2BioGRID, HPRD, UniProt12135764 14567678 26053850 details
BACE1GGA3BioGRID, UniProt14567678 26053850 details
BACE1ADAM10UniProt30538620 details
BACE1PSEN1HPRD, UniProt12901838 details
BACE1NCSTNBioGRID, HPRD12054507 details
BACE1FBXO2BioGRID20854419 details
BACE1PCSK9BioGRID18660751 details
BACE1BRI3BioGRID, HPRD15606899 details
BACE1RANBP9BioGRID, HPRD15606899 19251705 details
BACE1STUB1BioGRID25773675 details
BACE1USP8BioGRID27302062 details
BACE1HYOU1BioGRID29266373 details
BACE1KHSRPHPRD15606899 details
BACE1CMPK1HPRD15606899 details
BACE1PSAPHPRD15606899 details
BACE1ATP1B1HPRD15606899 details
BACE1PLSCR1HPRD12586838 details
BACE1MMP2BioGRID, HPRD, IntAct12586836 25241761 details
BACE1CSNK1DBioGRID, HPRD, IntAct11278841 25241761 details
BACE1FLOT2MINT24612608 details
BACE1FLOT1MINT24612608 details
BACE1RTN4BioGRID, UniProt16965550 details
BACE1RTN3BioGRID, UniProt16965550 details
BACE1TMX1BioGRID, UniProt20354142 29932915 details
BACE1SNX6UniProt20354142 details
BACE1ITM2BUniProt23701002 details
BACE1COPS5BioGRID23926111 details
BACE1SORT1BioGRID21245145 details
BACE1KCNQ1BioGRID26454161 details
BACE1NGFRBioGRID28869759 details
BACE1ITM2CHPRD15606899 details
BACE1LRP1HPRD15749709 details
BACE1FURINHPRD10887202 details
BACE1SCGB1D4BioGRID, IntAct28514442 details
BACE1KPNB1UniProt16965550 details
BACE1VPS11UniProt16965550 details
BACE1MYLK2UniProt20354142 details
BACE1TUBA1AUniProt20354142 details
BACE1SLC25A5UniProt20354142 details
BACE1ATP5F1AUniProt20354142 details
BACE1P4HBUniProt20354142 details
BACE1PPIAUniProt20354142 details
BACE1PPIBUniProt20354142 details
BACE1HSPA5UniProt20354142 details
BACE1CALRUniProt20354142 details
BACE1CANXUniProt20354142 details
BACE1GDI2UniProt20354142 details
BACE1TRAPPC5UniProt20354142 details
BACE1MOV10BioGRID22658674 details
BACE1NXF1BioGRID22658674 details