Entity Details

Primary name IRF3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14653
EntryNameIRF3_HUMAN
FullNameInterferon regulatory factor 3
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIRF3

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016032 viral process
GO:0019904 protein domain specific binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0039530 MDA-5 signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050727 regulation of inflammatory response
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071888 macrophage apoptotic process
GO:0097300 programmed necrotic cell death
GO:0098586 cellular response to virus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
IRF3_HUMANGRIP1_HUMANHPRD, MINT16362036 details
IRF3_HUMANTBK1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt12692549 15695821 15841462 16394098 17599067 18583960 18636086 19153231 19656901 20628368 21903422 22072751 22079989 22388039 23028469 24807708 25636800 25803835 28346439 30267576 31534043 32241891 details
IRF3_HUMANCBP_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT10082512 10521456 11314014 11940575 12473110 14668346 15107417 15502848 15582653 16154084 17015689 17126870 17138826 17296604 17761676 18309294 20581830 21903422 23746807 23824799 25733689 9488451 9566918 9660935 details
IRF3_HUMANIRF3_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT, UniProt10082512 11940575 12473110 15582653 15841462 16301520 18725644 19416887 19454348 19893624 20403326 20581830 21102435 21782231 22000020 22114345 22588174 22728658 23675467 23746807 23951545 23986588 24016850 24622840 24763515 25609649 25636800 26221961 26347139 26407194 26456228 27956528 30770245 31308089 32476569 32726803 details
IRF3_HUMANBAX_HUMANMINT20360684 details
IRF3_HUMANPEX19_HUMANBioGRID, IntAct21988832 details
IRF3_HUMANSGTA_HUMANBioGRID, IntAct21988832 details
IRF3_HUMANMAVS_HUMANBioGRID, HPRD, IntAct16153868 21903422 22908223 24379373 25636800 details
IRF3_HUMANRBL1_HUMANBioGRID, IntAct21903422 details
IRF3_HUMANEP300_HUMANBioGRID, HPRD, IntAct11314014 11940575 12473110 20604809 21903422 9488451 9660935 details
IRF3_HUMANRB_HUMANBioGRID, IntAct21903422 details
IRF3_HUMANIKKE_HUMANBioGRID, HPRD, UniProt12692549 15695821 18636086 19153231 22072751 27622505 28346439 32656094 details
IRF3_HUMANFA20C_HUMANIntAct22582013 details
IRF3_HUMANEWS_HUMANBioGRID, IntAct20211142 details
IRF3_HUMANPRDX1_HUMANBioGRID, HPRD16189514 details
IRF3_HUMANIRF7_HUMANBioGRID, HPRD11162841 18641315 details
IRF3_HUMANIRF5_HUMANBioGRID, HPRD11303025 12138184 details
IRF3_HUMANRO52_HUMANBioGRID18641315 19265157 22479513 details
IRF3_HUMANHERC5_HUMANBioGRID20308324 details
IRF3_HUMANHS90A_HUMANBioGRID16394098 20628368 details
IRF3_HUMANMK08_HUMANBioGRID19153595 details
IRF3_HUMANTOM70_HUMANBioGRID20628368 details
IRF3_HUMANTCAM1_HUMANBioGRID, HPRD14739303 25636800 details
IRF3_HUMANTRI26_HUMANBioGRID25763818 details
IRF3_HUMANFBX7_HUMANBioGRID27503909 details
IRF3_HUMANTRI55_HUMANBioGRID31391242 details
IRF3_HUMANTRI63_HUMANBioGRID31391242 details
IRF3_HUMANPSDE_HUMANBioGRID32476569 details
IRF3_HUMANUFL1_HUMANBioGRID32545848 details
IRF3_HUMANOGT1_HUMANBioGRID32994395 details
IRF3_HUMANPAI2_HUMANHPRD12883638 details
IRF3_HUMANPIAS4_HUMANBioGRID, HPRD, MINT15251447 details
IRF3_HUMANNUP62_HUMANMINT17599067 details
IRF3_HUMANGSHB_HUMANMINT18309294 details
IRF3_HUMANMAFB_HUMANBioGRID, InnateDB20581830 details
IRF3_HUMANHS90B_HUMANIntAct22939624 details
IRF3_HUMANAHSA1_HUMANIntAct25036637 details
IRF3_HUMANPTG3L_HUMANIntAct25036637 details
IRF3_HUMANAASD1_HUMANIntAct25036637 details
IRF3_HUMANRIOK3_HUMANUniProt24807708 details
IRF3_HUMANSTING_HUMANBioGRID, IntAct24622840 25636800 30018345 33086059 details
IRF3_HUMANUBB_HUMANIntAct24622840 details
IRF3_HUMANIRF1_HUMANIntAct32878885 details
IRF3_HUMANPP2AA_HUMANBioGRID, IntAct27956528 32878885 details
IRF3_HUMANISG15_HUMANIntAct32726803 details
IRF3_HUMANVIP1_HUMANBioGRID18636086 details
IRF3_HUMANDDX58_HUMANBioGRID16153868 18636086 details
IRF3_HUMANTANK_HUMANBioGRID17823124 details
IRF3_HUMANSOCS1_HUMANBioGRID21079688 29991678 details
IRF3_HUMANHDAC3_HUMANBioGRID22027828 details
IRF3_HUMANXIAP_HUMANBioGRID22072751 details
IRF3_HUMANCUL1_HUMANBioGRID17015689 details
IRF3_HUMANPIN1_HUMANBioGRID16699525 details
IRF3_HUMANTRAF3_HUMANBioGRID22079989 27980081 details
IRF3_HUMANMK09_HUMANBioGRID19153595 details
IRF3_HUMANTLR2_HUMANBioGRID17126870 details
IRF3_HUMANFOXO1_HUMANBioGRID23532851 details
IRF3_HUMANSMAD2_HUMANBioGRID14729983 details
IRF3_HUMANSMAD4_HUMANBioGRID14729983 details
IRF3_HUMANDEAF1_HUMANBioGRID23846693 details
IRF3_HUMANRPB1_HUMANBioGRID23994473 details
IRF3_HUMANCIKS_HUMANBioGRID23066157 details
IRF3_HUMANAKT1_HUMANBioGRID21106850 details
IRF3_HUMANTRAF2_HUMANBioGRID25636800 details
IRF3_HUMANTRAF6_HUMANBioGRID25636800 details
IRF3_HUMANULK1_HUMANBioGRID26347139 details
IRF3_HUMANIPO5_HUMANBioGRID26811330 details
IRF3_HUMANDDX3X_HUMANBioGRID27980081 details
IRF3_HUMANCBL_HUMANBioGRID27503123 details
IRF3_HUMANFBX17_HUMANBioGRID27956528 details
IRF3_HUMANWDR82_HUMANBioGRID26519536 details
IRF3_HUMANZC12A_HUMANBioGRID29920243 details
IRF3_HUMANFKBP8_HUMANBioGRID30267576 details
IRF3_HUMANOTUD1_HUMANBioGRID30100102 32075857 details
IRF3_HUMANM3K14_HUMANBioGRID30018345 details
IRF3_HUMANPINK1_HUMANBioGRID31139191 details
IRF3_HUMANYAP1_HUMANBioGRID31139191 details
IRF3_HUMANUBE3A_HUMANBioGRID30690483 details
IRF3_HUMANFBX6_HUMANBioGRID31308089 details
IRF3_HUMANSQSTM_HUMANBioGRID32476569 details
IRF3_HUMANCACO2_HUMANBioGRID32476569 details
IRF3_HUMANTCAM2_HUMANHPRD14517278 details
IRF3_HUMANSMUF2_HUMANHPRD15761153 details
IRF3_HUMANPPIB_HUMANHPRD15764595 details
IRF3_HUMANTF65_HUMANHPRD14557267 details
IRF3_HUMANSYT1_HUMANHPRD16143103 details