Entity Details

Primary name GREM1
Entity type gene
Source Source Link

Details

PrimaryID26585
RefseqGeneNG_033791
SymbolGREM1
Namegremlin 1, DAN family BMP antagonist
Chromosome15
Location15q13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGREM1_HUMAN

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002092 positive regulation of receptor internalization
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0009954 proximal/distal pattern formation
GO:0009986 cell surface
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0016015 morphogen activity
GO:0030199 collagen fibril organization
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030502 negative regulation of bone mineralization
GO:0030514 negative regulation of BMP signaling pathway
GO:0032331 negative regulation of chondrocyte differentiation
GO:0033689 negative regulation of osteoblast proliferation
GO:0036122 BMP binding
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0045668 negative regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046851 negative regulation of bone remodeling
GO:0048018 receptor ligand activity
GO:0048263 determination of dorsal identity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051893 regulation of focal adhesion assembly
GO:0051973 positive regulation of telomerase activity
GO:0060173 limb development
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676 ureteric bud formation
GO:0062023 collagen-containing extracellular matrix
GO:0090027 negative regulation of monocyte chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090291 negative regulation of osteoclast proliferation
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155 negative regulation of bone trabecula formation
GO:1900158 negative regulation of bone mineralization involved in bone maturation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000273 positive regulation of signaling receptor activity
GO:2000727 positive regulation of cardiac muscle cell differentiation

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
GREM1YWHAHHPRD, IntAct16545136 details
GREM1KDRbhf-ucl20660291 details
GREM1KRTAP12-2BioGRID, IntAct32296183 details
GREM1MDFIBioGRID, IntAct32296183 details
GREM1BMP2HPRD15064755 details
GREM1CGASBioGRID30471916 details