Entity Details

Primary name HSF1
Entity type gene
Source Source Link

Details

PrimaryID3297
RefseqGene
SymbolHSF1
Nameheat shock transcription factor 1
Chromosome8
Location8q24.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsHSF1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0006952 defense response
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell population proliferation
GO:0009299 mRNA transcription
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014823 response to activity
GO:0016032 viral process
GO:0016605 PML body
GO:0019901 protein kinase binding
GO:0031072 heat shock protein binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031490 chromatin DNA binding
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034620 cellular response to unfolded protein
GO:0034622 cellular protein-containing complex assembly
GO:0035865 cellular response to potassium ion
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043621 protein self-association
GO:0045651 positive regulation of macrophage differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051028 mRNA transport
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051879 Hsp90 protein binding
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress
GO:0061770 translation elongation factor binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071276 cellular response to cadmium ion
GO:0071280 cellular response to copper ion
GO:0071392 cellular response to estradiol stimulus
GO:0071480 cellular response to gamma radiation
GO:0072738 cellular response to diamide
GO:0090084 negative regulation of inclusion body assembly
GO:0090261 positive regulation of inclusion body assembly
GO:0097165 nuclear stress granule
GO:0097431 mitotic spindle pole
GO:0097677 STAT family protein binding
GO:0098847 sequence-specific single stranded DNA binding
GO:0101031 chaperone complex
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900034 regulation of cellular response to heat
GO:1900365 positive regulation of mRNA polyadenylation
GO:1901215 negative regulation of neuron death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903936 cellular response to sodium arsenite
GO:1904385 cellular response to angiotensin
GO:1904528 positive regulation of microtubule binding
GO:1904843 cellular response to nitroglycerin
GO:1904845 cellular response to L-glutamine
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:1990904 ribonucleoprotein complex
GO:1990910 response to hypobaric hypoxia
GO:1990911 response to psychosocial stress
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining

Diseases

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Interactions

151 interactions

InteractorPartnerSourcesPublicationsLink
HSF1ENO2BioGRID, HPRD, IntAct16169070 details
HSF1STUB1BioGRID, HPRD, MINT14532117 16293251 23344957 details
HSF1MAPKAPK2BioGRID, HPRD, IntAct16278218 details
HSF1CHST10BioGRID, IntAct21988832 details
HSF1CDK6BioGRID, IntAct22094256 details
HSF1PRKCQIntAct23352416 details
HSF1HSF2BioGRID, DIP, HPRD, IntAct12813038 25036637 26186194 26496610 26727490 28514442 details
HSF1MINK1MINT25816751 details
HSF1PLK1BioGRID, IntAct18794143 27173435 unassigned1312 details
HSF1HSPA8BioGRID, HPRD, IntAct16293251 28514442 7639722 details
HSF1SUMO1BioGRID, DIP, HPRD12646186 12665592 19684601 22748127 details
HSF1HSF1BioGRID, DIP, HPRD, IntAct12865437 19758120 20098725 26727490 29997244 details
HSF1MAPK8BioGRID, DIP, HPRD10747973 27043084 details
HSF1WDR88IntAct32814053 details
HSF1RPUSD4IntAct32814053 details
HSF1TMEM185AIntAct32814053 details
HSF1KLF15IntAct32814053 details
HSF1ITGB3BPIntAct32814053 details
HSF1LPIN1IntAct32814053 details
HSF1PRMT5IntAct32814053 details
HSF1ZNF232IntAct32814053 details
HSF1SCGB1A1IntAct32814053 details
HSF1SYMPKBioGRID, HPRD14707147 details
HSF1RALBP1BioGRID12621024 details
HSF1HSP90AA1BioGRID11583998 12621024 16278218 18599869 20885985 22367781 26517842 9222609 details
HSF1HSPA4BioGRID14532117 1628823 20565132 9222609 details
HSF1FKBP5BioGRID9222609 details
HSF1FKBP4BioGRID11583998 9222609 details
HSF1PPIDBioGRID9222609 details
HSF1PTGES3BioGRID23022381 9222609 details
HSF1HSPA1ABioGRID, HPRD1628823 21784850 9499401 9699716 details
HSF1DNAJB1BioGRID, HPRD9499401 details
HSF1TBPBioGRID, HPRD11005381 details
HSF1GTF2BBioGRID, HPRD11005381 details
HSF1CEBPBBioGRID, HPRD11801594 details
HSF1XRCC5BioGRID, HPRD9325337 details
HSF1PRKDCBioGRID, HPRD9325337 details
HSF1XRCC6BioGRID, HPRD11162511 details
HSF1HSBP1BioGRID, HPRD9649501 details
HSF1MTA1BioGRID17922035 details
HSF1FILIP1BioGRID21784850 details
HSF1CDC20BioGRID18059335 18794143 details
HSF1TAF9BioGRID, HPRD10821850 11005381 details
HSF1UBE2IBioGRID19684601 details
HSF1DAXXBioGRID15016915 20620219 details
HSF1MAPK1BioGRID10747973 details
HSF1NCOA6BioGRID14960326 details
HSF1CREBBPBioGRID, HPRD14960326 details
HSF1HSP90AB1BioGRID26517842 details
HSF1RNF20BioGRID30649429 details
HSF1EEF1DBioGRID30649429 details
HSF1PIM2BioGRID31409638 details
HSF1REPS1HPRD12621024 details
HSF1TTC5MINT18451878 details
HSF1YWHAEHPRD, MINT12917326 15364926 details
HSF1EEF1GMINT21597468 details
HSF1KPNA3BioGRID, IntAct25036637 27173435 unassigned1312 details
HSF1BAG3BioGRID, IntAct23824909 25036637 27173435 unassigned1312 details
HSF1HSPBP1BioGRID, IntAct25036637 27173435 28514442 unassigned1312 details
HSF1HSPB1BioGRID, IntAct19597476 25036637 details
HSF1KPNA4BioGRID, IntAct25036637 27173435 unassigned1312 details
HSF1LMNAMINT25425574 details
HSF1IER5MINT25816751 26496226 details
HSF1RTL9BioGRID, IntAct27173435 unassigned1312 details
HSF1CARMIL1BioGRID, IntAct27173435 unassigned1312 details
HSF1HSPA1LBioGRID, IntAct27173435 unassigned1312 details
HSF1BUB1BioGRID, IntAct27173435 unassigned1312 details
HSF1SMC6BioGRID, IntAct27173435 unassigned1312 details
HSF1EFTUD2BioGRID, IntAct27173435 unassigned1312 details
HSF1MNS1BioGRID, IntAct27173435 unassigned1312 details
HSF1GTF3C4BioGRID, IntAct27173435 unassigned1312 details
HSF1EPS15L1BioGRID, IntAct27173435 unassigned1312 details
HSF1MAPRE2BioGRID, IntAct27173435 unassigned1312 details
HSF1GAPVD1BioGRID, IntAct27173435 unassigned1312 details
HSF1SMC1ABioGRID, IntAct27173435 unassigned1312 details
HSF1MCM6BioGRID, IntAct27173435 unassigned1312 details
HSF1DCAF7BioGRID, IntAct27173435 unassigned1312 details
HSF1RAB28BioGRID, IntAct27173435 unassigned1312 details
HSF1MCM2BioGRID, IntAct27173435 unassigned1312 details
HSF1MCM4BioGRID, IntAct27173435 unassigned1312 details
HSF1SPAG9BioGRID, IntAct27173435 unassigned1312 details
HSF1USP15BioGRID, IntAct27173435 unassigned1312 details
HSF1IVNS1ABPBioGRID, IntAct27173435 unassigned1312 details
HSF1CFAP20BioGRID, IntAct27173435 unassigned1312 details
HSF1CEP63IntAct31413325 details
HSF1SMARCA4BioGRID11486022 20353823 21079652 details
HSF1SMARCB1BioGRID11486022 details
HSF1STAT1BioGRID, HPRD9880553 details
HSF1SIRT1BioGRID19229036 details
HSF1HDAC1BioGRID17922035 19793920 details
HSF1HDAC2BioGRID17922035 19793920 details
HSF1CHD3BioGRID17922035 details
HSF1HSPB2BioGRID19597476 details
HSF1PCGF2BioGRID18211895 details
HSF1BTRCBioGRID18794143 details
HSF1MAD2L1BioGRID18794143 details
HSF1STRAPBioGRID18451878 details
HSF1FBXW7BioGRID25720964 31244938 31409638 details
HSF1NEDD4BioGRID26503960 details
HSF1EP300BioGRID28104499 details
HSF1HYPKBioGRID23272104 details
HSF1PSMD10BioGRID25905985 details
HSF1TRIM11BioGRID30563406 details
HSF1PDK3BioGRID31244938 details
HSF1GSK3BBioGRID31244938 details
HSF1MAPK3BioGRID, HPRD31244938 8940068 details
HSF1TP53BioGRID32097779 details
HSF1CSNK2A1HPRD12659875 details
HSF1SUMO3HPRD15576338 details
HSF1TAF1HPRD11005381 details
HSF1SUB1HPRD11005381 details
HSF1GTF2A2HPRD11005381 details
HSF1MAPK9HPRD11527157 details
HSF1GSK3AHPRD12665592 details
HSF1TAF7HPRD11005381 details
HSF1HSPA4LBioGRID, IntAct25036637 details
HSF1NME2BioGRID, IntAct25036637 details
HSF1NME1-NME2IntAct25036637 details
HSF1HSF4BioGRID, IntAct25036637 details
HSF1PKMIntAct24606918 details
HSF1MYH13BioGRID, IntAct26496610 details
HSF1LURAP1LBioGRID, IntAct26186194 28514442 details
HSF1BAG4BioGRID, IntAct28514442 details
HSF1DENND5BBioGRID22939629 details
HSF1AARS1BioGRID22863883 details
HSF1DR1BioGRID22863883 details
HSF1AAMPBioGRID22863883 details
HSF1ANKMY2BioGRID22863883 details
HSF1ARPC1BBioGRID22863883 details
HSF1BTF3L4BioGRID22863883 details
HSF1GON7BioGRID22863883 details
HSF1CALUBioGRID22863883 details
HSF1CBSBioGRID22863883 details
HSF1CTPS2BioGRID22863883 details
HSF1DHPSBioGRID22863883 details
HSF1DTD1BioGRID22863883 details
HSF1GOPCBioGRID22863883 details
HSF1LRSAM1BioGRID22863883 details
HSF1MTMR2BioGRID22863883 details
HSF1RPRD1ABioGRID22863883 details
HSF1SURF2BioGRID22863883 details
HSF1TPRKBBioGRID22863883 details
HSF1UBE3ABioGRID22863883 details
HSF1ZPR1BioGRID22863883 details
HSF1IPO11BioGRID22863883 details
HSF1PCLAFBioGRID22863883 details
HSF1PLIN3BioGRID22863883 details
HSF1SRP9BioGRID22863883 details
HSF1EAPPBioGRID28561026 details
HSF1TSSC4BioGRID28561026 details
HSF1PRPF8BioGRID28515276 details