Entity Details

Primary name KPCD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15139
EntryNameKPCD1_HUMAN
FullNameSerine/threonine-protein kinase D1
TaxID9606
Evidenceevidence at protein level
Length912
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPRKD1

GO terms

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GOName
GO:0000421 autophagosome membrane
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0010508 positive regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0010837 regulation of keratinocyte proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0030154 cell differentiation
GO:0031647 regulation of protein stability
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034198 cellular response to amino acid starvation
GO:0034599 cellular response to oxidative stress
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045806 negative regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048193 Golgi vesicle transport
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060548 negative regulation of cell death
GO:0071447 cellular response to hydroperoxide
GO:0089700 protein kinase D signaling
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901727 positive regulation of histone deacetylase activity
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001044 regulation of integrin-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015727 Protein kinase C mu-relatedFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB11752 Bryostatin 1Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
KPCD1_HUMANMT2_HUMANBioGRID, HPRD, IntAct14550308 details
KPCD1_HUMANCADH1_HUMANIntAct15695390 details
KPCD1_HUMANMK13_HUMANIntAct19135240 details
KPCD1_HUMANC1QBP_HUMANBioGRID, HPRD, UniProt10831594 details
KPCD1_HUMANKPCD1_HUMANBioGRID, HPRD, UniProt10831594 10867018 11741879 12628923 31980649 details
KPCD1_HUMANMARK2_HUMANDIP19011111 details
KPCD1_HUMANKPCE_HUMANDIP, HPRD10092595 19011111 details
KPCD1_HUMAN1433T_HUMANBioGRID, HPRD, IntAct10092600 10831594 31980649 details
KPCD1_HUMAN1433Z_HUMANBioGRID, IntAct12893243 31980649 details
KPCD1_HUMANHSPB1_HUMANBioGRID, IntAct15728188 31980649 details
KPCD1_HUMANARFP1_HUMANIntAct22981988 details
KPCD1_HUMANADAP1_HUMANBioGRID, HPRD12893243 details
KPCD1_HUMANBTK_HUMANBioGRID, HPRD10561498 details
KPCD1_HUMANJUN_HUMANBioGRID, HPRD11948398 12628923 details
KPCD1_HUMANCSN7A_HUMANBioGRID12628923 details
KPCD1_HUMANCSN2_HUMANBioGRID12628923 details
KPCD1_HUMANCSN5_HUMANBioGRID12628923 details
KPCD1_HUMANP53_HUMANBioGRID12628923 details
KPCD1_HUMANIBTK_HUMANBioGRID21482705 details
KPCD1_HUMANAKP13_HUMANBioGRID15383279 details
KPCD1_HUMANPP14A_HUMANBioGRID, HPRD15003508 details
KPCD1_HUMANAP2A_HUMANBioGRID18845787 details
KPCD1_HUMANNOS1_HUMANBioGRID24740233 details
KPCD1_HUMANUBP28_HUMANBioGRID24623306 details
KPCD1_HUMANSPY2_HUMANBioGRID19458088 details
KPCD1_HUMANHS90B_HUMANIntAct22939624 details
KPCD1_HUMANNHRF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KPCD1_HUMANYAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
KPCD1_HUMANHDAC5_HUMANBioGRID, HPRD11081517 11114197 15367659 15728188 21081666 26137861 details
KPCD1_HUMANMK09_HUMANBioGRID, HPRD11948398 details
KPCD1_HUMANMK08_HUMANBioGRID, HPRD11948398 details
KPCD1_HUMANPLCG1_HUMANBioGRID, HPRD8885868 details
KPCD1_HUMANKSYK_HUMANBioGRID, HPRD8885868 details
KPCD1_HUMANPLCG2_HUMANBioGRID, HPRD8885868 details
KPCD1_HUMANHDAC7_HUMANBioGRID, HPRD15623513 15738054 19029091 details
KPCD1_HUMANBAD_HUMANBioGRID20179209 details
KPCD1_HUMANGAN_HUMANBioGRID26460568 details
KPCD1_HUMANSNAI1_HUMANBioGRID28892081 details
KPCD1_HUMANFBW1A_HUMANBioGRID30619291 details
KPCD1_HUMANSRC_HUMANHPRD12637538 details
KPCD1_HUMANKPCL_HUMANHPRD10867018 11741879 details
KPCD1_HUMANKDIS_HUMANHPRD10998417 details
KPCD1_HUMANRACK1_HUMANHPRD11884618 details
KPCD1_HUMANIGF1R_HUMANHPRD11884618 details
KPCD1_HUMANEGFR_HUMANHPRD10523301 2984676 2987962 details
KPCD1_HUMANABL1_HUMANHPRD12637538 details
KPCD1_HUMANEPAS1_HUMANHPRD17024177 details