Entity Details

Primary name IRF1
Entity type gene
Source Source Link

Details

PrimaryID3659
RefseqGeneNG_011450
SymbolIRF1
Nameinterferon regulatory factor 1
Chromosome5
Location5q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-06-06
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsIRF1_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0002819 regulation of adaptive immune response
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell population proliferation
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045088 regulation of innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
IRF1CDKN1BBioGRID, IntAct21988832 details
IRF1QARS1BioGRID, IntAct21988832 details
IRF1STAT1BioGRID, HPRD, IntAct, NTNU10764778 16512786 17525742 19124747 8810328 details
IRF1SUMO1DIP17942705 details
IRF1NFE2L2IntAct32911434 details
IRF1IRF9BioGRID, IntAct12799427 20211142 details
IRF1KAT2BBioGRID, HPRD10022868 11304541 23670564 details
IRF1KAT2ABioGRID10022868 details
IRF1IRF8BioGRID, HPRD11483597 7768900 9742224 details
IRF1HMGA1BioGRID, HPRD10357819 details
IRF1EP300BioGRID, HPRD10438822 14662860 15509808 23670564 details
IRF1CREBBPBioGRID9659924 details
IRF1STUB1BioGRID20947504 23134341 23729439 26330542 28362432 30042418 details
IRF1TRAF3BioGRID21903422 details
IRF1KEAP1BioGRID21903422 details
IRF1NPM1BioGRID21245151 details
IRF1YBX1BioGRID21245151 details
IRF1TRIM28BioGRID21245151 23134341 details
IRF1SPI1BioGRID11483597 9593745 details
IRF1MDM2BioGRID23134341 24583282 24721577 27795392 details
IRF1SETBioGRID23134341 details
IRF1BIRC3BioGRID24464131 29545793 details
IRF1IRF2BioGRID16982896 details
IRF1XAF1BioGRID30042418 details
IRF1GSK3BBioGRID30854564 details
IRF1SPOPBioGRID31776466 details
IRF1ULK2IntAct17353931 details
IRF1SMARCA4BioGRID, IntAct16195385 17182572 details
IRF1IRF3IntAct32878885 details
IRF1SP2BioGRID19482358 details
IRF1HSP90AA1BioGRID23729439 details
IRF1HSPA1ABioGRID23729439 details
IRF1CBLBioGRID21740303 details
IRF1H3C1BioGRID21740303 details
IRF1PRDM1BioGRID19828629 details
IRF1TRAF6BioGRID29545793 details
IRF1FBXW7BioGRID30854564 details
IRF1UBE3ABioGRID30690483 details
IRF1NFKB1HPRD8746784 details
IRF1RELAHPRD8746784 details
IRF1NCLBioGRID, IntAct30021884 details
IRF1HCFC1BioGRID21903422 details
IRF1SEC63BioGRID21903422 details
IRF1TRMT2ABioGRID21903422 details
IRF1IFNL1IntAct22058416 details
IRF1STAT3IntAct17182572 details
IRF1FOXP3IntAct18641303 details
IRF1STAT6NTNU8810328 details
IRF1CCL2IntAct21760952 details
IRF1RC3H1BioGRID31451648 details