Entity Details

Primary name IRS1
Entity type gene
Source Source Link

Details

PrimaryID3667
RefseqGeneNG_015830
SymbolIRS1
Nameinsulin receptor substrate 1
Chromosome2
Location2q36.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsIRS1_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 protein kinase C binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030159 signaling receptor complex adaptor activity
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042593 glucose homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0071398 cellular response to fatty acid

Diseases

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Interactions

124 interactions

InteractorPartnerSourcesPublicationsLink
IRS1YWHAEBioGRID, HPRD, MINT30240640 9111084 9312143 details
IRS1INSRBioGRID, DIP, HPRD, IntAct, MINT10455177 11606564 11781100 15629149 16582879 17167487 25667086 7499194 7935368 8626379 8662806 details
IRS1PIK3CABioGRID, IntAct, MINT12933652 14511371 16150444 16354680 23604317 23643389 27684187 details
IRS1PIK3R1BioGRID, HPRD, IntAct, MINT11403293 11416002 12107746 12173038 12220227 12730242 1334490 1381348 14511371 14632132 15514089 16043515 16150444 16230374 16354680 16880210 17640984 19561084 22974441 23439647 23643389 25273559 25814554 26839216 29526746 30240640 7659087 7680095 7680644 7935461 8175658 8382612 8388384 8628286 9564850 details
IRS1ERBB2BioGRID, MINT16273093 details
IRS1EGFRBioGRID, MINT16273093 details
IRS1DDR1IntAct17721511 details
IRS1PTPN1BioGRID, HPRD, MINT10660596 11579209 details
IRS1IGF1RBioGRID, HPRD, IntAct10082579 12220227 15629149 7541045 7559507 8530377 8662806 8776723 8895367 details
IRS1PTPN11BioGRID, HPRD, MINT11781100 22974441 7513703 7935386 8505282 9535915 9756938 details
IRS1GRB2BioGRID, HPRD, IntAct12173038 21706016 22974441 7488107 7629070 8388384 8491186 8536716 8810325 details
IRS1NUMBBioGRID, IntAct25814554 details
IRS1PIK3R3BioGRID, HPRD, IntAct10417350 25814554 7542745 9415396 details
IRS1BCAR3BioGRID, IntAct25814554 details
IRS1PELI1BioGRID, IntAct25814554 details
IRS1LRRK2IntAct24947832 details
IRS1YWHABBioGRID, HPRD, IntAct28514442 30240640 9422753 details
IRS1PTPRDBioGRID, MINT22305495 details
IRS1IL4RHPRD, IntAct8599766 details
IRS1PTK2BioGRID9822703 details
IRS1MAPK8BioGRID, HPRD10722755 11606564 12351658 12417588 details
IRS1JAK1BioGRID, HPRD11162588 7499365 9492017 details
IRS1JAK2BioGRID, HPRD11208867 12960006 15316008 9492017 details
IRS1KHDRBS1BioGRID11604231 22005517 8175658 details
IRS1GRB10BioGRID12783867 8621530 details
IRS1MTORBioGRID, HPRD11287630 16354680 30240640 details
IRS1AP3S1BioGRID, HPRD9792713 details
IRS1PRKCDBioGRID, HPRD12031982 15364919 15516986 details
IRS1NCK2BioGRID9843575 details
IRS1AKT1BioGRID, HPRD10497255 17640984 details
IRS1HDAC2BioGRID15522123 details
IRS1NEDD4BioGRID19953087 details
IRS1RPTORBioGRID, HPRD16354680 19561084 30240640 details
IRS1FBXW8BioGRID18498745 23045529 33854235 details
IRS1UBCBioGRID23045529 details
IRS1RPS6KB1BioGRID18498745 23045529 details
IRS1APPBioGRID21832049 details
IRS1PLCG2BioGRID22974441 details
IRS1SH2B1BioGRID15316008 22974441 details
IRS1PTPRUBioGRID11781100 details
IRS1PIK3R2BioGRID, HPRD11120660 12730242 23604317 30240640 7559478 details
IRS1FBXO25BioGRID23940030 details
IRS1MAPK3BioGRID17640984 details
IRS1TRIM72BioGRID27810898 29884820 32055715 details
IRS1PASKBioGRID9761740 details
IRS1IRS1BioGRID, HPRD10411883 8995282 details
IRS1RAD51BioGRID, HPRD14559999 details
IRS1GRB14HPRD9748281 details
IRS1NTRK1HPRD11147812 details
IRS1PHIPHPRD11018022 details
IRS1SFNBioGRID, MINT15778465 details
IRS1SIRT1BioGRID, UniProt17901049 21241768 details
IRS1PABPC1MINT23770097 details
IRS1YWHAGBioGRID, HPRD, IntAct15324660 28514442 30240640 details
IRS1YWHAHBioGRID, IntAct11969417 28514442 30240640 details
IRS1SOCS1BioGRID, HPRD11208867 12228220 17276034 29991678 details
IRS1CHUKBioGRID, HPRD12351658 details
IRS1IKBKBBioGRID, HPRD10722755 11606564 12351658 details
IRS1BCL2BioGRID10679027 details
IRS1BCL2L1BioGRID, HPRD10679027 details
IRS1JAK3BioGRID, HPRD7499365 details
IRS1NISCHBioGRID11912194 details
IRS1IRS2BioGRID12554758 details
IRS1UBTFBioGRID, HPRD12554758 17332342 details
IRS1ALKBioGRID, HPRD14968112 9174053 details
IRS1CBLBBioGRID16734387 29729186 details
IRS1ESR1BioGRID12821935 details
IRS1CBLBioGRID10854852 29729186 details
IRS1SOCS3BioGRID, HPRD12228220 15514089 details
IRS1PIK3CBBioGRID23604317 29526746 details
IRS1DVL2BioGRID24616100 details
IRS1CUL7BioGRID18498745 29269414 details
IRS1CUL1BioGRID30240640 details
IRS1BTRCBioGRID30240640 details
IRS1FBXW11BioGRID30240640 details
IRS1YWHAQBioGRID30240640 details
IRS1YWHAZBioGRID, HPRD30240640 9312143 details
IRS1CSNK1A1BioGRID30240640 details
IRS1CSNK2A2BioGRID30240640 details
IRS1CSNK2BBioGRID, HPRD30240640 8349691 details
IRS1GSK3BBioGRID29526746 details
IRS1CD36BioGRID29269414 details
IRS1FYNBioGRID, HPRD29269414 8631859 details
IRS1PTPRFBioGRID, HPRD10660596 15588985 8732688 8995282 details
IRS1CD2APBioGRID29729186 details
IRS1USP9XBioGRID30338032 details
IRS1KLHL9BioGRID31515271 details
IRS1KLHL13BioGRID31515271 details
IRS1CUL3BioGRID31515271 details
IRS1ATP2A1HPRD9295312 details
IRS1CSNK2A1HPRD8349691 details
IRS1MAPK1HPRD16131083 details
IRS1NPM1HPRD8633037 details
IRS1PRKCQHPRD15364919 details
IRS1PRKCGHPRD15364919 details
IRS1PDPK1HPRD15802620 details
IRS1ATP2A2HPRD9295312 details
IRS1BCRHPRD12560071 details
IRS1CRKHPRD8621590 8810325 9837978 details
IRS1FERHPRD11006284 details
IRS1FESHPRD10856136 details
IRS1GHRHPRD7782332 details
IRS1CAV1HPRD15003536 details
IRS1ROCK1HPRD11739394 details
IRS1ATP2A3HPRD12524443 details
IRS1PTPRCHPRD8557683 details
IRS1TYK2HPRD8550573 details
IRS1PRKCZHPRD11063744 details
IRS1SHC1HPRD7499194 details
IRS1TUBHPRD10455176 details
IRS1MAPK9HPRD12417588 details
IRS1SIK2HPRD12624099 details
IRS1SMAD3BioGRID, IntAct18729074 details
IRS1EIF4EMINT23770097 details
IRS1EGLN3BioGRID, IntAct26972000 details
IRS1CYTH3DIP17167487 details
IRS1CYTH2DIP17167487 details
IRS1RNF4BioGRID29180619 details
IRS1ESR2BioGRID29509190 details
IRS1RNF123BioGRID29676528 details
IRS1ZDHHC18BioGRID30658672 details
IRS1ZDHHC23BioGRID30658672 details
IRS1DYRK1ABioGRID30773093 details
IRS1VIRMABioGRID29507755 details