Entity Details

Primary name KS6A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15418
EntryNameKS6A1_HUMAN
FullNameRibosomal protein S6 kinase alpha-1
TaxID9606
Evidenceevidence at protein level
Length735
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesRPS6KA1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0018105 peptidyl-serine phosphorylation
GO:0030307 positive regulation of cell growth
GO:0035556 intracellular signal transduction
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043555 regulation of translation in response to stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0045202 synapse
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0072574 hepatocyte proliferation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000491 positive regulation of hepatic stellate cell activation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016239 Ribosomal protein S6 kinase IIFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR041906 Ribosomal S6 kinase, N-terminal catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04751 Purvalanol ADrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

102 interactions

InteractorPartnerSourcesPublicationsLink
KS6A1_HUMANEF2K_HUMANBioGRID, HPRD, MINT11171059 11500364 14709557 15024086 details
KS6A1_HUMAN1433B_HUMANBioGRID, HPRD, MINT12618428 details
KS6A1_HUMANCREB1_HUMANBioGRID, HPRD, IntAct11175347 12235136 16282323 21832046 8688081 9687510 9829964 details
KS6A1_HUMANIF4B_HUMANMINT16763566 details
KS6A1_HUMANTAU_HUMANBioGRID, MINT17512525 details
KS6A1_HUMANVASP_HUMANI2D21423205 details
KS6A1_HUMANRS6_HUMANI2D21423205 details
KS6A1_HUMANATX3_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANTCPD_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANCOF1_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANGBP2_HUMANBioGRID, MINT21900206 22863883 details
KS6A1_HUMANEM55_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANPHAX_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANPPM1G_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANSRSF5_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANTTK_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANTERA_HUMANBioGRID, MINT21900206 details
KS6A1_HUMANMK01_HUMANBioGRID, HPRD, IntAct10922375 12594221 12618428 12832467 16039586 23455922 23519423 24623782 29997244 31980649 32814053 9430688 9915826 details
KS6A1_HUMANMAD1_HUMANBioGRID, DIP18451027 details
KS6A1_HUMANCDN1B_HUMANBioGRID, DIP19470470 details
KS6A1_HUMANSCRIB_HUMANIntAct30126976 details
KS6A1_HUMANS10A1_HUMANUniProt31837246 details
KS6A1_HUMANS10A2_HUMANUniProt31837246 details
KS6A1_HUMANS10A4_HUMANUniProt31837246 details
KS6A1_HUMANS10A6_HUMANUniProt31837246 details
KS6A1_HUMANS100B_HUMANUniProt31837246 details
KS6A1_HUMANS100P_HUMANUniProt31837246 details
KS6A1_HUMANBAD_HUMANBioGRID, HPRD10521512 10837486 10880354 10949026 11500364 12897128 9381178 details
KS6A1_HUMANTSC2_HUMANBioGRID, HPRD15342917 15757502 details
KS6A1_HUMANCHSP1_HUMANBioGRID15910284 details
KS6A1_HUMANIKBA_HUMANBioGRID, HPRD10723127 8601309 9214631 9261139 9721103 9914500 details
KS6A1_HUMANTOB1_HUMANBioGRID11260258 details
KS6A1_HUMANESR1_HUMANBioGRID, HPRD11139588 11432835 11507039 12093745 9528769 details
KS6A1_HUMANYBOX1_HUMANBioGRID19036157 details
KS6A1_HUMANPDCD4_HUMANBioGRID22586265 details
KS6A1_HUMANRPTOR_HUMANBioGRID18722121 details
KS6A1_HUMANGSK3B_HUMANBioGRID19470470 details
KS6A1_HUMANPDIP3_HUMANBioGRID25049393 details
KS6A1_HUMANRHG07_HUMANBioGRID16338927 details
KS6A1_HUMANDPTOR_HUMANBioGRID22017876 details
KS6A1_HUMANFGFR1_HUMANBioGRID, HPRD15117958 19261810 details
KS6A1_HUMANUBE2T_HUMANBioGRID28162934 details
KS6A1_HUMANARHGC_HUMANBioGRID30726710 details
KS6A1_HUMANMAST2_HUMANBioGRID30726710 details
KS6A1_HUMANGOPC_HUMANBioGRID30726710 31678930 details
KS6A1_HUMANPDZD7_HUMANBioGRID30726710 details
KS6A1_HUMANGRD2I_HUMANBioGRID30726710 details
KS6A1_HUMANMAST1_HUMANBioGRID30726710 details
KS6A1_HUMANPAR3L_HUMANBioGRID30726710 details
KS6A1_HUMANPZRN4_HUMANBioGRID30726710 details
KS6A1_HUMANHTRA1_HUMANBioGRID30726710 details
KS6A1_HUMANMAGI1_HUMANBioGRID, HPRD16217014 30726710 30944250 details
KS6A1_HUMANMAGI2_HUMANBioGRID30726710 details
KS6A1_HUMANSNTG2_HUMANBioGRID30726710 details
KS6A1_HUMANGORS2_HUMANBioGRID30726710 details
KS6A1_HUMANNHRF3_HUMANBioGRID30726710 details
KS6A1_HUMANSNTA1_HUMANBioGRID30726710 details
KS6A1_HUMANGRASP_HUMANBioGRID30726710 details
KS6A1_HUMANMAGI3_HUMANBioGRID30726710 details
KS6A1_HUMANARHGB_HUMANBioGRID30726710 details
KS6A1_HUMANSYJ2B_HUMANBioGRID30726710 details
KS6A1_HUMANPZRN3_HUMANBioGRID30726710 details
KS6A1_HUMANWHRN_HUMANBioGRID30726710 details
KS6A1_HUMANSNTB1_HUMANBioGRID30726710 details
KS6A1_HUMANNHRF2_HUMANBioGRID30726710 details
KS6A1_HUMANPTN3_HUMANBioGRID28675297 30726710 details
KS6A1_HUMANSHRM2_HUMANBioGRID30726710 details
KS6A1_HUMANLIMK2_HUMANBioGRID30726710 details
KS6A1_HUMANGORS1_HUMANBioGRID30726710 details
KS6A1_HUMANLNX1_HUMANBioGRID30726710 details
KS6A1_HUMANDLG4_HUMANBioGRID30726710 details
KS6A1_HUMANERBIN_HUMANBioGRID30726710 details
KS6A1_HUMANNEB1_HUMANBioGRID30726710 details
KS6A1_HUMANSNX27_HUMANBioGRID30726710 details
KS6A1_HUMANP53_HUMANBioGRID15867353 details
KS6A1_HUMANENAH_HUMANI2D21423205 details
KS6A1_HUMANHS90B_HUMANBioGRID, IntAct22939624 23455922 31980649 details
KS6A1_HUMANAKAP8_HUMANUniProt22130794 details
KS6A1_HUMANMK03_HUMANBioGRID, HPRD, IntAct12832467 31980649 9915826 details
KS6A1_HUMANKS6A1_HUMANBioGRID, HPRD, UniProt10648825 12618428 17192257 31837246 31980649 9430688 details
KS6A1_HUMANTSC1_HUMANBioGRID15342917 details
KS6A1_HUMANCBP_HUMANBioGRID, HPRD12540838 15929978 8756728 details
KS6A1_HUMANUBR5_HUMANBioGRID28559278 details
KS6A1_HUMANNR4A1_HUMANHPRD16223362 details
KS6A1_HUMANCEBPB_HUMANHPRD10635333 details
KS6A1_HUMANL1CAM_HUMANHPRD8663493 details
KS6A1_HUMANETV1_HUMANHPRD11551945 12213813 12569367 12917345 details
KS6A1_HUMANSRF_HUMANHPRD10318869 10753652 8413226 details
KS6A1_HUMANPPR3A_HUMANHPRD10648825 details
KS6A1_HUMANGMFB_HUMANHPRD9030586 details
KS6A1_HUMANPDPK1_HUMANHPRD10480933 9430688 details
KS6A1_HUMANTRMB_HUMANHPRD15861136 details
KS6A1_HUMANTOB2_HUMANHPRD11260258 details
KS6A1_HUMANGRB2_HUMANHPRD8630373 details
KS6A1_HUMANMITF_HUMANHPRD10673502 details
KS6A1_HUMANKSYK_HUMANHPRD9218456 details
KS6A1_HUMANNR4A3_HUMANHPRD16223362 details
KS6A1_HUMANNR4A2_HUMANHPRD16223362 details
KS6A1_HUMANEF1D_HUMANHPRD9353277 details
KS6A1_HUMANMTOR_HUMANHPRD15905173 details
KS6A1_HUMANFOS_HUMANHPRD1545828 8248197 details