Entity Details

Primary name MEF2C
Entity type gene
Source Source Link

Details

PrimaryID4208
RefseqGeneNG_023427
SymbolMEF2C
Namemyocyte enhancer factor 2C
Chromosome5
Location5q14.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-11-01
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMEF2C_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001764 neuron migration
GO:0001782 B cell homeostasis
GO:0001947 heart looping
GO:0001958 endochondral ossification
GO:0001974 blood vessel remodeling
GO:0002062 chondrocyte differentiation
GO:0002467 germinal center formation
GO:0002634 regulation of germinal center formation
GO:0002931 response to ischemia
GO:0003138 primary heart field specification
GO:0003139 secondary heart field specification
GO:0003151 outflow tract morphogenesis
GO:0003185 sinoatrial valve morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007399 nervous system development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007521 muscle cell fate determination
GO:0007611 learning or memory
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0014033 neural crest cell differentiation
GO:0014902 myotube differentiation
GO:0016528 sarcoplasm
GO:0016607 nuclear speck
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030220 platelet formation
GO:0030279 negative regulation of ossification
GO:0030318 melanocyte differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030890 positive regulation of B cell proliferation
GO:0032991 protein-containing complex
GO:0035690 cellular response to drug
GO:0035984 cellular response to trichostatin A
GO:0042100 B cell proliferation
GO:0042826 histone deacetylase binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043406 positive regulation of MAP kinase activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045652 regulation of megakaryocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046928 regulation of neurotransmitter secretion
GO:0046982 protein heterodimerization activity
GO:0048167 regulation of synaptic plasticity
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048666 neuron development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050853 B cell receptor signaling pathway
GO:0051145 smooth muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051963 regulation of synapse assembly
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060025 regulation of synaptic activity
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060079 excitatory postsynaptic potential
GO:0060998 regulation of dendritic spine development
GO:0061333 renal tubule morphogenesis
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071498 cellular response to fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072102 glomerulus morphogenesis
GO:0072160 nephron tubule epithelial cell differentiation
GO:0098794 postsynapse
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000310 regulation of NMDA receptor activity
GO:2000311 regulation of AMPA receptor activity
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:2000987 positive regulation of behavioral fear response
GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis
GO:2001016 positive regulation of skeletal muscle cell differentiation

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
MEF2CHDAC4BioGRID, HPRD, IntAct, MINT10523670 11279209 11486037 11504882 11792813 12709441 15743821 15964851 18332106 23752268 31040226 32296183 details
MEF2CMAPK14BioGRID, HPRD, IntAct10330143 10805738 20936779 9069290 9753748 details
MEF2CCOPS5BioGRID, IntAct20936779 details
MEF2CEPAS1BioGRID, IntAct20936779 details
MEF2CHDAC9BioGRID, IntAct20211142 20936779 details
MEF2CMAPK7BioGRID, HPRD, IntAct20936779 9384584 9753748 details
MEF2CSPTBN1BioGRID, IntAct20936779 details
MEF2CYWHAZBioGRID, IntAct20936779 details
MEF2CPLA2G12ABioGRID, IntAct21988832 details
MEF2CMYLK2MINT21556048 details
MEF2CEP300BioGRID, HPRD, MINT21556048 9001254 details
MEF2CHDAC5BioGRID, HPRD, IntAct10737771 11279209 20211142 23752268 details
MEF2CHDAC7BioGRID, IntAct11279209 18463162 23752268 details
MEF2CSP1BioGRID, HPRD9748305 details
MEF2CSOX18BioGRID, HPRD11554755 details
MEF2CSMAD2BioGRID, HPRD11160896 details
MEF2CTEAD1BioGRID, HPRD12061776 12861002 details
MEF2CMYOD1BioGRID15743821 9418854 details
MEF2CMYOGBioGRID8548800 details
MEF2CNCOA2BioGRID, HPRD12130539 details
MEF2CIFRD1BioGRID15743821 details
MEF2CASCL1BioGRID8900141 details
MEF2CUBE2IBioGRID15561718 details
MEF2CMEF2CBioGRID, HPRD11744164 12130539 details
MEF2CVGLL4HPRD15140898 details
MEF2CTFCP2IntAct20195357 details
MEF2CRTN3IntAct31413325 details
MEF2CAARS1IntAct31413325 details
MEF2CZBTB44IntAct31413325 details
MEF2CZNF350IntAct31413325 details
MEF2CSMARCE1IntAct31413325 details
MEF2CUBE3AMINT31988313 details
MEF2CTWIST2BioGRID, HPRD11809751 details
MEF2CSIRT1BioGRID19553684 details
MEF2CSKP2BioGRID25733682 details
MEF2CTULP3BioGRID33187986 details
MEF2CMEF2DHPRD9858528 details
MEF2CGATA4HPRD10790371 details
MEF2CVGLL2HPRD12376544 details
MEF2CCSNK2A1HPRD8663403 details
MEF2CNOTCH1HPRD10082551 details
MEF2CCDK1HPRD16478538 details
MEF2CCCNB1HPRD16478538 details
MEF2CMEF2ABioGRID, MINT25609649 details
MEF2CJUNMINT25609649 details
MEF2CMEF2BBioGRID, IntAct28514442 details
MEF2CBORCS8-MEF2BIntAct28514442 details
MEF2CHIPK2DIP23565059 details
MEF2CMYCBioGRID32140074 details
MEF2CDDX58BioGRID32513696 details