Entity Details

Primary name SMAD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15797
EntryNameSMAD1_HUMAN
FullNameMothers against decapentaplegic homolog 1
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesSMAD1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001657 ureteric bud development
GO:0001710 mesodermal cell fate commitment
GO:0002051 osteoblast fate commitment
GO:0003161 cardiac conduction system development
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007276 gamete generation
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009880 embryonic pattern specification
GO:0010628 positive regulation of gene expression
GO:0016021 integral component of membrane
GO:0016579 protein deubiquitination
GO:0017151 DEAD/H-box RNA helicase binding
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030509 BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0031053 primary miRNA processing
GO:0032991 protein-containing complex
GO:0042592 homeostatic process
GO:0042802 identical protein binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051148 negative regulation of muscle cell differentiation
GO:0051216 cartilage development
GO:0060038 cardiac muscle cell proliferation
GO:0060348 bone development
GO:0060395 SMAD protein signal transduction
GO:0061036 positive regulation of cartilage development
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070878 primary miRNA binding
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0071407 cellular response to organic cyclic compound
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903672 positive regulation of sprouting angiogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

196 interactions

InteractorPartnerSourcesPublicationsLink
SMAD1_HUMANZ512B_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANPIAS1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANXPC_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANPIAS4_HUMANBioGRID, HPRD, MINT12904571 15231748 details
SMAD1_HUMANSMUF1_HUMANBioGRID, HPRD, IntAct, MINT14701756 15221015 15231748 15761153 16611643 17289590 17510966 17676934 19914168 19917253 21685363 21708152 22152476 22670624 24828823 28881580 details
SMAD1_HUMANNOTC2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANGMEB1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANSMUF2_HUMANBioGRID, DIP, HPRD, IntAct, MINT11016919 11158580 14701756 15221015 15231748 20937913 28468752 28514442 32296183 details
SMAD1_HUMANZEB2_HUMANBioGRID, HPRD, MINT10400677 12714599 15231748 22365546 details
SMAD1_HUMANSMAD5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANTTF2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANCAMP1_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANKMT2D_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANSF3B1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANRFX1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANMAN1_HUMANBioGRID, HPRD, IntAct, MINT15231748 15489854 32296183 details
SMAD1_HUMANZSCA4_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANSMAD4_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT10531362 11700304 11779505 12167862 12874272 14701756 15231748 15761153 17183365 21454478 24412244 26555259 28468752 31467278 32296183 9111321 9436979 details
SMAD1_HUMANSMAD1_HUMANBioGRID, HPRD, IntAct, MINT11016919 11779505 15231748 15246821 9111321 details
SMAD1_HUMANPSD11_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANSOX5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANCHMP3_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANMRTFB_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANTTF1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANAP2A2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANCASL_HUMANBioGRID, HPRD, MINT11118211 15231748 details
SMAD1_HUMANSTA13_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANINP4A_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANALDR_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANPIGQ_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANPUM1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANPSB4_HUMANBioGRID, HPRD, IntAct, MINT11438941 11571290 12097147 15231748 32296183 details
SMAD1_HUMANANR27_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANMGAP_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANI2BP1_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANCILK1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANZDHC3_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANSMCE1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANZN510_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANMAST4_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANPSMD1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANZN251_HUMANBioGRID, MINT15231748 details
SMAD1_HUMANZNF76_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANHBP1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANRU17_HUMANBioGRID, HPRD, MINT15231748 details
SMAD1_HUMANNEDD4_HUMANBioGRID, MINT15231748 21308777 details
SMAD1_HUMANANDR_HUMANBioGRID, HPRD, MINT17183365 23734213 details
SMAD1_HUMANGSK3B_HUMANBioGRID, IntAct18045539 25241761 details
SMAD1_HUMANCDK8_HUMANBioGRID, IntAct19914168 details
SMAD1_HUMANYAP1_HUMANBioGRID, IntAct19914168 21685363 details
SMAD1_HUMANSFRP3_HUMANBioGRID, MINT21900206 details
SMAD1_HUMANAPC_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANAXIN2_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANBMR1A_HUMANBioGRID, HPRD, MINT11438941 24412244 9136927 details
SMAD1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANCCND1_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANCTNA1_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANRHG07_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANMLH1_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANMSH2_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANMUTYH_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANRASN_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANPTN12_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
SMAD1_HUMANSMAD6_HUMANbhf-ucl, BioGRID, HPRD11483516 12857866 9256479 9436979 details
SMAD1_HUMANEPN2_HUMANBioGRID, IntAct32296183 details
SMAD1_HUMANIPO8_HUMANIntAct17785517 details
SMAD1_HUMANNF2L2_HUMANIntAct32911434 details
SMAD1_HUMANOPTN_HUMANIntAct32814053 details
SMAD1_HUMANCREST_HUMANBioGRID, IntAct20211142 details
SMAD1_HUMANHXA5_HUMANBioGRID, IntAct20211142 details
SMAD1_HUMANEWS_HUMANHPRD, IntAct15231748 20211142 details
SMAD1_HUMANHIPK2_HUMANBioGRID, HPRD12874272 details
SMAD1_HUMANSKI_HUMANBioGRID12426322 12874272 14699069 details
SMAD1_HUMANDVL1_HUMANBioGRID12650946 details
SMAD1_HUMANERBIN_HUMANBioGRID, HPRD12650946 details
SMAD1_HUMANNGN1_HUMANBioGRID, HPRD11239394 details
SMAD1_HUMANSNIP1_HUMANBioGRID, HPRD10887155 details
SMAD1_HUMANFOXG1_HUMANBioGRID, HPRD11387330 details
SMAD1_HUMANHXC8_HUMANBioGRID, HPRD10224145 11139569 details
SMAD1_HUMANACVR1_HUMANBioGRID, HPRD10085121 10583507 10652350 28847510 9136927 9748228 details
SMAD1_HUMANOAZ3_HUMANBioGRID11438941 details
SMAD1_HUMANTCF20_HUMANBioGRID20211142 details
SMAD1_HUMANNKX32_HUMANBioGRID14612411 details
SMAD1_HUMANTYY1_HUMANBioGRID12808092 details
SMAD1_HUMANMECOM_HUMANBioGRID15849193 details
SMAD1_HUMANZCH12_HUMANBioGRID18160706 19416967 details
SMAD1_HUMANOAZ1_HUMANBioGRID11571290 details
SMAD1_HUMANCHIP_HUMANBioGRID, HPRD14701756 15708501 15761153 21454478 23344957 details
SMAD1_HUMANMK01_HUMANBioGRID, HPRD17289590 18045539 19914168 9335504 details
SMAD1_HUMANCDK7_HUMANBioGRID19914168 details
SMAD1_HUMANCDK9_HUMANBioGRID19914168 details
SMAD1_HUMANSMAD2_HUMANBioGRID18729074 28205554 9111321 details
SMAD1_HUMANSMAD3_HUMANBioGRID, HPRD15761153 18729074 9111321 details
SMAD1_HUMANA4_HUMANBioGRID21832049 details
SMAD1_HUMANACVL1_HUMANBioGRID19592636 details
SMAD1_HUMANUBC_HUMANBioGRID11438941 details
SMAD1_HUMANMEP50_HUMANBioGRID23734213 details
SMAD1_HUMANPARD3_HUMANBioGRID12650946 details
SMAD1_HUMANDNM3L_HUMANBioGRID24952347 details
SMAD1_HUMANLMNA_HUMANBioGRID24623722 details
SMAD1_HUMANDACH1_HUMANBioGRID28205554 details
SMAD1_HUMANMP2K3_HUMANBioGRID28205554 details
SMAD1_HUMANSTK11_HUMANBioGRID28205554 details
SMAD1_HUMANTET2_HUMANBioGRID30404004 details
SMAD1_HUMANZBT44_HUMANHPRD15231748 details
SMAD1_HUMANZNF8_HUMANHPRD12370310 details
SMAD1_HUMANHXA13_HUMANHPRD16087734 details
SMAD1_HUMANCO4A1_HUMANHPRD14732718 details
SMAD1_HUMANMBD1_HUMANHPRD15231748 details
SMAD1_HUMANMED15_HUMANBioGRID, MINT12167862 details
SMAD1_HUMANMED24_HUMANBioGRID, MINT12167862 details
SMAD1_HUMANMED6_HUMANBioGRID, HPRD, MINT12167862 27703004 details
SMAD1_HUMANTBA4A_HUMANMINT17183365 details
SMAD1_HUMANUCHL3_HUMANBioGRID, MINT21453705 details
SMAD1_HUMANGLI3_HUMANBioGRID, HPRD, IntAct25241761 9843199 details
SMAD1_HUMANCTDS2_HUMANDIP16882717 details
SMAD1_HUMANCTDS1_HUMANDIP16882717 details
SMAD1_HUMANCTDSL_HUMANDIP16882717 details
SMAD1_HUMANDDX5_HUMANDIP18548003 details
SMAD1_HUMANRNC_HUMANDIP18548003 details
SMAD1_HUMANZEB1_HUMANBioGRID12743038 details
SMAD1_HUMANTGIF1_HUMANBioGRID10199400 details
SMAD1_HUMANEP300_HUMANBioGRID, HPRD10205054 10673036 16613856 20851880 22365546 details
SMAD1_HUMANCBP_HUMANBioGRID10673036 11239394 details
SMAD1_HUMANSTAT3_HUMANBioGRID10205054 details
SMAD1_HUMANZN423_HUMANBioGRID, HPRD10660046 14630787 details
SMAD1_HUMANTOB1_HUMANBioGRID, HPRD11163184 details
SMAD1_HUMANRUNX2_HUMANBioGRID10531362 10962029 17215250 20851880 details
SMAD1_HUMANRUNX1_HUMANBioGRID10531362 details
SMAD1_HUMANRUNX3_HUMANBioGRID10531362 details
SMAD1_HUMANWWP1_HUMANBioGRID15221015 15359284 details
SMAD1_HUMANHMGA2_HUMANBioGRID18425117 details
SMAD1_HUMANKAT2A_HUMANBioGRID15009097 details
SMAD1_HUMANHDAC1_HUMANBioGRID14699069 details
SMAD1_HUMANKDM6B_HUMANBioGRID20667911 details
SMAD1_HUMANNU214_HUMANBioGRID17289590 details
SMAD1_HUMANFOXO3_HUMANBioGRID17289590 details
SMAD1_HUMANUSP9X_HUMANBioGRID19135894 details
SMAD1_HUMANSKIL_HUMANBioGRID, HPRD12426322 details
SMAD1_HUMANMEN1_HUMANBioGRID, HPRD12649288 27703004 details
SMAD1_HUMANUBP15_HUMANBioGRID21947082 22344298 details
SMAD1_HUMANHGS_HUMANBioGRID11094085 details
SMAD1_HUMANPAX6_HUMANBioGRID17251190 details
SMAD1_HUMANPPM1A_HUMANBioGRID22588298 details
SMAD1_HUMANP53_HUMANBioGRID22588298 details
SMAD1_HUMANZN521_HUMANBioGRID, HPRD14630787 details
SMAD1_HUMANLEF1_HUMANBioGRID, HPRD10890911 15750622 details
SMAD1_HUMANXPO1_HUMANBioGRID, HPRD12519765 26673895 details
SMAD1_HUMANSMAD7_HUMANBioGRID26555259 details
SMAD1_HUMANID3_HUMANBioGRID22884369 details
SMAD1_HUMANTGFR1_HUMANHPRD10085121 9136927 9748228 details
SMAD1_HUMANBTG2_HUMANHPRD15542835 details
SMAD1_HUMANGDF6_HUMANHPRD15246821 details
SMAD1_HUMANECSIT_HUMANHPRD14633973 details
SMAD1_HUMANARL4D_HUMANHPRD15761153 details
SMAD1_HUMANARHG6_HUMANHPRD15761153 details
SMAD1_HUMANBTBD2_HUMANHPRD15761153 details
SMAD1_HUMANE2AK4_HUMANHPRD15761153 details
SMAD1_HUMANELP3_HUMANHPRD15761153 details
SMAD1_HUMANFXL12_HUMANHPRD15761153 details
SMAD1_HUMANFBX30_HUMANHPRD15761153 details
SMAD1_HUMANFHL5_HUMANHPRD15761153 details
SMAD1_HUMANGSC_HUMANHPRD15761153 details
SMAD1_HUMANING2_HUMANHPRD15761153 details
SMAD1_HUMANNAT9_HUMANHPRD15761153 details
SMAD1_HUMANPAK1_HUMANHPRD15761153 details
SMAD1_HUMANPKHB1_HUMANHPRD15761153 details
SMAD1_HUMANPREB_HUMANHPRD15761153 details
SMAD1_HUMANRAB2B_HUMANHPRD15761153 details
SMAD1_HUMANRAB30_HUMANHPRD15761153 details
SMAD1_HUMANRAB38_HUMANHPRD15761153 details
SMAD1_HUMANRAB3B_HUMANHPRD15761153 details
SMAD1_HUMANRAB6B_HUMANHPRD15761153 details
SMAD1_HUMANRAC2_HUMANHPRD15761153 details
SMAD1_HUMANRAN_HUMANHPRD15761153 details
SMAD1_HUMANRAP2A_HUMANHPRD15761153 details
SMAD1_HUMANRHES_HUMANHPRD15761153 details
SMAD1_HUMANRASLC_HUMANHPRD15761153 details
SMAD1_HUMANREBL1_HUMANHPRD15761153 details
SMAD1_HUMANRHOG_HUMANHPRD15761153 details
SMAD1_HUMANRS27A_HUMANHPRD15761153 details
SMAD1_HUMANSQSTM_HUMANHPRD15761153 details
SMAD1_HUMANTNNT1_HUMANHPRD15761153 details
SMAD1_HUMANTRIP6_HUMANHPRD15761153 details
SMAD1_HUMANRL40_HUMANHPRD15761153 details
SMAD1_HUMANUBP45_HUMANHPRD15761153 details
SMAD1_HUMANMELT_HUMANHPRD15761153 details
SMAD1_HUMANKAT2B_HUMANHPRD14500836 details
SMAD1_HUMANUBE2Z_HUMANHPRD15761153 details
SMAD1_HUMANUBXN1_HUMANHPRD15761153 details
SMAD1_HUMANSUV91_HUMANHPRD15107829 details