Entity Details

Primary name NCK1
Entity type gene
Source Source Link

Details

PrimaryID4690
RefseqGene
SymbolNCK1
NameNCK adaptor protein 1
Chromosome3
Location3q22.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-07
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsNCK1_HUMAN

GO terms

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GOName
GO:0000164 protein phosphatase type 1 complex
GO:0004860 protein kinase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007015 actin filament organization
GO:0007172 signal complex assembly
GO:0008093 cytoskeletal anchor activity
GO:0010976 positive regulation of neuron projection development
GO:0012506 vesicle membrane
GO:0019904 protein domain specific binding
GO:0030032 lamellipodium assembly
GO:0030159 signaling receptor complex adaptor activity
GO:0030334 regulation of cell migration
GO:0030674 protein-macromolecule adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0030971 receptor tyrosine kinase binding
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045296 cadherin binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046875 ephrin receptor binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
GO:0070262 peptidyl-serine dephosphorylation
GO:0071074 eukaryotic initiation factor eIF2 binding
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903676 positive regulation of cap-dependent translational initiation
GO:1903679 positive regulation of cap-independent translational initiation
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Diseases

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Interactions

302 interactions

InteractorPartnerSourcesPublicationsLink
NCK1WASBioGRID, HPRD, MINT10747096 11340081 12135674 24287595 7565724 details
NCK1EGFRBioGRID, HPRD, IntAct, MINT10026169 1333047 16273093 24658140 25402006 31980649 8662998 9362449 details
NCK1CBLBioGRID, HPRD, MINT10204582 10372803 10829062 10967110 11494134 16503409 24287595 7517397 9851874 details
NCK1ABI1BioGRID, HPRD, UniProt11418237 11557983 details
NCK1SYNJ1MINT16137687 details
NCK1TNK2BioGRID, HPRD, IntAct, MINT11278436 16137687 21309750 26496610 details
NCK1ERBB3BioGRID, MINT16273093 22973453 details
NCK1WIPF1BioGRID, HPRD, IntAct12620186 26496610 9694849 details
NCK1SOS1BioGRID, HPRD, IntAct10026169 10206341 17474147 32203420 7862111 8810325 details
NCK1DNM1BioGRID, HPRD, IntAct10206341 11557983 details
NCK1PAK2BioGRID, HPRD, IntAct, MINT11160719 16374509 32296183 details
NCK1ADAM15BioGRID, HPRD, MINT16374509 18296648 details
NCK1CASTIntAct17474147 details
NCK1DLX4IntAct17474147 details
NCK1SOS2IntAct17474147 details
NCK1BRPF3IntAct17474147 details
NCK1SYNJ2HPRD, IntAct10805734 17474147 details
NCK1CDC27IntAct17474147 details
NCK1DAB2IntAct17474147 details
NCK1NELFBIntAct17474147 details
NCK1PTPN4IntAct17474147 details
NCK1SNX17IntAct17474147 details
NCK1VPS13AIntAct17474147 details
NCK1SPENIntAct17474147 details
NCK1ELK3IntAct17474147 details
NCK1JAK2IntAct17474147 details
NCK1DUSP15IntAct17474147 details
NCK1ASXL1IntAct17474147 details
NCK1GHRBioGRID, IntAct17474147 25241761 details
NCK1MEPEIntAct17474147 details
NCK1DOCK3IntAct17474147 details
NCK1ABL2BioGRID, IntAct17474147 25241761 details
NCK1BRCA1IntAct17474147 details
NCK1RPL13IntAct17474147 details
NCK1PDIA2IntAct17474147 details
NCK1FOXH1IntAct17474147 details
NCK1FLNBIntAct17474147 details
NCK1H1-4IntAct17474147 details
NCK1TRAIPIntAct17474147 details
NCK1SLC23A1IntAct17474147 details
NCK1BRD4IntAct17474147 details
NCK1ASAP2IntAct17474147 details
NCK1FYB1IntAct17474147 22074159 details
NCK1ECT2IntAct17474147 details
NCK1SNX7IntAct17474147 details
NCK1AIREIntAct17474147 details
NCK1SLC24A1IntAct17474147 details
NCK1CELSR2IntAct17474147 details
NCK1SHANK2IntAct17474147 details
NCK1RAG1IntAct17474147 details
NCK1ISG20L2IntAct17474147 details
NCK1DTNBP1IntAct17474147 details
NCK1SUV39H2IntAct17474147 details
NCK1SASH1IntAct17474147 details
NCK1RAPGEF1IntAct17474147 details
NCK1CKAP5IntAct17474147 details
NCK1LRRC3IntAct17474147 details
NCK1PIK3C2BIntAct17474147 details
NCK1TPSAB1IntAct17474147 details
NCK1CHAF1AIntAct17474147 details
NCK1TPSB2IntAct17474147 details
NCK1KIF13AIntAct17474147 details
NCK1ABCG5IntAct17474147 details
NCK1CSDE1IntAct17474147 details
NCK1ID4IntAct17474147 details
NCK1ARHGEF11IntAct17474147 details
NCK1PALM2AKAP2IntAct17474147 details
NCK1TGDSIntAct17474147 details
NCK1EPXIntAct17474147 details
NCK1RRASBioGRID, HPRD, IntAct10671570 17474147 details
NCK1MAP4IntAct17474147 details
NCK1TPX2IntAct17474147 details
NCK1ASAP1IntAct, MINT16636290 17474147 details
NCK1TGOLN2IntAct17474147 details
NCK1SNX12IntAct17474147 details
NCK1PIK3CDIntAct17474147 details
NCK1DLGAP4BioGRID, IntAct17474147 32296183 details
NCK1FCGR2BIntAct17474147 details
NCK1FCGR2CIntAct17474147 details
NCK1GABBR1IntAct17474147 details
NCK1BAZ2AIntAct17474147 details
NCK1DAG1BioGRID, IntAct11724572 17474147 details
NCK1GNSIntAct17474147 details
NCK1SNX8IntAct17474147 details
NCK1DLGAP1IntAct17474147 details
NCK1DLGAP3IntAct17474147 details
NCK1SCARF2IntAct17474147 details
NCK1GSTZ1IntAct17474147 details
NCK1SELENONIntAct17474147 details
NCK1MAP4K1BioGRID, HPRD, IntAct, MINT11279207 17474147 22974441 9346925 9891069 details
NCK1FAM110AIntAct17474147 details
NCK1RIMS2IntAct17474147 details
NCK1ABL1BioGRID, HPRD, IntAct10372803 10967110 11494134 12379115 17474147 7926767 details
NCK1EPS15IntAct17474147 details
NCK1SP1IntAct17474147 details
NCK1HNRNPRIntAct17474147 details
NCK1PHACTR2IntAct17474147 details
NCK1NKX2-1IntAct17474147 details
NCK1TMPOIntAct17474147 details
NCK1CYP4F2IntAct17474147 details
NCK1CNTNAP1IntAct17474147 details
NCK1BICRAIntAct17474147 details
NCK1ATP2A3IntAct17474147 details
NCK1F2RL2IntAct17474147 details
NCK1PRXIntAct17474147 details
NCK1CELSR3IntAct17474147 details
NCK1PNMA2IntAct17474147 details
NCK1RIMS1IntAct17474147 details
NCK1TULP1IntAct17474147 details
NCK1AGERIntAct17474147 details
NCK1RPP38IntAct17474147 details
NCK1MYLKIntAct17474147 details
NCK1GAD1IntAct17474147 details
NCK1ASB16IntAct17474147 details
NCK1NEK8IntAct17474147 details
NCK1RIN3IntAct17474147 details
NCK1KIFC2IntAct17474147 details
NCK1TRIM39IntAct17474147 details
NCK1SEMA7AIntAct17474147 details
NCK1C6IntAct17474147 details
NCK1KMT2BIntAct17474147 details
NCK1CSMD2IntAct17474147 details
NCK1MAP4K5IntAct17474147 details
NCK1SHROOM2IntAct17474147 details
NCK1SNX3IntAct17474147 details
NCK1GPR45IntAct17474147 details
NCK1EFSBioGRID, IntAct17474147 26871637 details
NCK1MAP4K3IntAct17474147 details
NCK1NCKAP5HPRD, IntAct17474147 9344857 details
NCK1HOXC8IntAct17474147 details
NCK1URB1IntAct17474147 details
NCK1PAX7IntAct17474147 details
NCK1IL3RAIntAct17474147 details
NCK1FLNCIntAct17474147 details
NCK1NFASCIntAct17474147 details
NCK1CHRDIntAct17474147 details
NCK1RP1L1IntAct17474147 details
NCK1AKAP6IntAct17474147 details
NCK1PRICKLE3IntAct17474147 details
NCK1CCR10IntAct17474147 details
NCK1ACAP1IntAct17474147 details
NCK1CCKBRIntAct17474147 details
NCK1WASLBioGRID, DIP, HPRD, IntAct11340081 16595635 17474147 26496610 26871637 details
NCK1TLR9IntAct17474147 details
NCK1FANCAIntAct17474147 details
NCK1TNIKHPRD, IntAct10521462 17474147 details
NCK1ANK2IntAct17474147 details
NCK1EHMT2IntAct17474147 details
NCK1CNTFRIntAct17474147 details
NCK1AFF2IntAct17474147 details
NCK1SF3B4IntAct17474147 details
NCK1DROSHABioGRID, IntAct17474147 26496610 details
NCK1NXPH3IntAct17474147 details
NCK1OXTIntAct17474147 details
NCK1NR5A1IntAct17474147 details
NCK1MED14IntAct17474147 details
NCK1POLR1BIntAct17474147 details
NCK1MYRIPIntAct17474147 details
NCK1P2RX7IntAct17474147 details
NCK1RYR1IntAct17474147 details
NCK1APOL5IntAct17474147 details
NCK1PAX3IntAct17474147 details
NCK1NOTCH3IntAct17474147 details
NCK1NPVFIntAct17474147 details
NCK1DOCK1IntAct17474147 details
NCK1SLC22A3IntAct17474147 details
NCK1CD3EBioGRID, HPRD, MINT12110186 17617578 18955169 details
NCK1FASLGBioGRID, DIP, HPRD, IntAct11741599 16595635 19807924 26871637 details
NCK1LCP2BioGRID, HPRD, IntAct, MINT10229072 15388330 15929943 20562827 21725281 22267732 31467278 details
NCK1EPHB1BioGRID, HPRD, MINT9430661 details
NCK1PHC2BioGRID, IntAct21988832 details
NCK1ADGRL2BioGRID, IntAct21988832 details
NCK1KIAA1522BioGRID, IntAct21988832 details
NCK1RASA1BioGRID, HPRD, IntAct10508618 21664272 9233798 details
NCK1UBA52BioGRID, MINT21900206 details
NCK1BLNKBioGRID, HPRD, IntAct11487585 25241761 9697839 details
NCK1GAB1BioGRID, IntAct24728074 details
NCK1KITBioGRID, IntAct24728074 details
NCK1METBioGRID, IntAct24728074 details
NCK1OLIG1BioGRID, IntAct25814554 details
NCK1PIK3R3BioGRID, IntAct25814554 details
NCK1SH2D1ABioGRID, IntAct25814554 details
NCK1PIK3AP1BioGRID, IntAct32296183 details
NCK1CHN2BioGRID, IntAct32203420 32296183 details
NCK1NHSL2BioGRID, IntAct32296183 details
NCK1NCKIPSDBioGRID, HPRD, IntAct11278500 14559906 28514442 details
NCK1ADAM19UniProt25825872 details
NCK1KHDRBS1BioGRID, HPRD, IntAct10805734 22745667 31413325 9010224 9362449 details
NCK1MINK1BioGRID, HPRD15469942 details
NCK1ERBB4BioGRID16729043 22973453 details
NCK1ARHGAP32BioGRID, HPRD12819203 details
NCK1SOCS1BioGRID, HPRD10022833 29991678 details
NCK1PKN2BioGRID, HPRD10026169 8910519 details
NCK1MAP4K4BioGRID, HPRD10805734 9135144 details
NCK1PXNBioGRID, HPRD10330411 details
NCK1NEDD9BioGRID, HPRD10808124 8879209 details
NCK1PTK2BioGRID11950595 8879209 details
NCK1TBK1BioGRID, HPRD7706279 details
NCK1PAK1BioGRID, HPRD10026169 10330411 10372803 11157752 11278241 11557983 8824201 9851874 details
NCK1SOCS7BioGRID, HPRD9344857 details
NCK1DRD4BioGRID, HPRD9843378 details
NCK1GAB2BioGRID10391903 details
NCK1BCAR1BioGRID, HPRD12135674 22974441 details
NCK1PFN1BioGRID9694849 details
NCK1CAV2BioGRID, HPRD12091389 details
NCK1DOK1BioGRID, HPRD11551902 12087092 22974441 details
NCK1FGFR1BioGRID22974441 details
NCK1SYNPOBioGRID24287595 details
NCK1EIF2S2BioGRID, HPRD11959995 details
NCK1ABI2BioGRID26871637 details
NCK1SORBS3BioGRID26871637 details
NCK1GMPPABioGRID26871637 details
NCK1NUTM2FBioGRID26871637 details
NCK1HOMEZBioGRID26871637 details
NCK1FCHO1BioGRID26871637 details
NCK1ERBB2BioGRID22973453 details
NCK1NTRK2HPRD12074588 details
NCK1NCKAP1HPRD11418237 8605018 details
NCK1FLT1HPRD9600074 details
NCK1FLT3HPRD10409713 details
NCK1RHOUHPRD, MINT15556869 details
NCK1DOK2BioGRID, HPRD, MINT10428862 11689432 details
NCK1NPHS1HPRD, IntAct16525419 16543952 details
NCK1KDRBioGRID, HPRD, MINT12214271 16966330 9405464 details
NCK1FYNMINT16966330 details
NCK1CD247MINT18320063 details
NCK1TUBA1ABioGRID, MINT17868192 details
NCK1PDGFRBBioGRID, HPRD, MINT10026169 1333047 7692233 9362449 details
NCK1CBLBHPRD, MINT16503409 25218436 details
NCK1RNGTTDIP25137142 details
NCK1ADAM10UniProt25036101 details
NCK1STK38BioGRID, IntAct31980649 details
NCK1ARHGEF7BioGRID, HPRD, IntAct10330411 14559906 31980649 details
NCK1DCCBioGRID, HPRD12149262 details
NCK1RALGPS1BioGRID10747847 details
NCK1PIK3R1BioGRID11418612 details
NCK1SYKBioGRID22267732 details
NCK1INPP5DBioGRID22267732 details
NCK1UBASH3BBioGRID22267732 details
NCK1GRB2BioGRID22267732 details
NCK1HSPA5BioGRID15908432 details
NCK1RAPGEF5BioGRID8561895 details
NCK1DAB1BioGRID14517291 details
NCK1PRPS2BioGRID31980649 details
NCK1EPHB2HPRD9233798 details
NCK1RAC1HPRD10766742 details
NCK1CSNK1G2HPRD9006905 details
NCK1WASF1HPRD8605018 details
NCK1EIF2B2HPRD11959995 details
NCK1CYFIP2HPRD8605018 details
NCK1BRK1HPRD8605018 details
NCK1DRD3HPRD9843378 details
NCK1PLCG1HPRD9314836 details
NCK1CRKHPRD9837978 details
NCK1PAK3HPRD11278553 details
NCK1FRS2HPRD12154000 details
NCK1LRFN4BioGRID, IntAct, MINT22677168 28514442 details
NCK1TRIM14BioGRID, IntAct26496610 details
NCK1WIPF2BioGRID, IntAct26496610 details
NCK1CLINT1BioGRID, IntAct26496610 details
NCK1TRRAPBioGRID, IntAct26496610 details
NCK1UXTBioGRID, IntAct26496610 details
NCK1PAPSS1BioGRID, IntAct26496610 details
NCK1RTEL1BioGRID, IntAct26496610 details
NCK1UBR4BioGRID, IntAct26496610 details
NCK1RAD54LBioGRID, IntAct26496610 details
NCK1HEATR3BioGRID, IntAct26496610 details
NCK1CEP170BioGRID, IntAct26638075 details
NCK1NCK2BioGRID, IntAct26186194 28514442 31980649 details
NCK1FAM217BBioGRID, IntAct26186194 28514442 details
NCK1CPNE5BioGRID, IntAct28514442 details
NCK1ADIPOR2BioGRID, IntAct26186194 28514442 details
NCK1DDR1MINT22057045 details
NCK1CANXBioGRID, IntAct29568061 details
NCK1PRPSAP2BioGRID, IntAct31980649 details
NCK1MBPBioGRID, IntAct31980649 details
NCK1JUPBioGRID, IntAct31980649 details
NCK1PRPS1BioGRID, IntAct31980649 details
NCK1GIT2BioGRID, IntAct31980649 details
NCK1PRPSAP1BioGRID, IntAct31980649 details
NCK1GIT1BioGRID, IntAct31980649 details
NCK1IVNS1ABPBioGRID, IntAct31980649 details
NCK1RPLP0BioGRID, IntAct31980649 details
NCK1P4HBBioGRID, IntAct31980649 details
NCK1DSPBioGRID, IntAct31980649 details
NCK1RPL35ABioGRID, IntAct31980649 details
NCK1RPL12BioGRID, IntAct31980649 details
NCK1RPL30BioGRID, IntAct31980649 details
NCK1RPL10ABioGRID, IntAct31980649 details
NCK1DSG1BioGRID, IntAct31980649 details
NCK1RPL6BioGRID, IntAct31980649 details
NCK1ABCF1BioGRID, IntAct31980649 details
NCK1CHN1BioGRID, IntAct32203420 details
NCK1FMR1BioGRID26344197 details
NCK1APBB2BioGRID26496610 details
NCK1CDH1BioGRID25468996 details
NCK1DUSP12BioGRID27432908 details
NCK1ARHGEF2BioGRID29089450 details
NCK1DCAF15BioGRID31452512 details
NCK1PTPN12BioGRID28675297 details
NCK1NCK1BioGRID31980649 details
NCK1HNRNPH1BioGRID26760575 details