Entity Details

Primary name NKX3-1
Entity type gene
Source Source Link

Details

PrimaryID4824
RefseqGene
SymbolNKX3-1
NameNK3 homeobox 1
Chromosome8
Location8p21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNKX31_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001656 metanephros development
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organism development
GO:0007431 salivary gland development
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030154 cell differentiation
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0030521 androgen receptor signaling pathway
GO:0032880 regulation of protein localization
GO:0033574 response to testosterone
GO:0035690 cellular response to drug
GO:0035907 dorsal aorta development
GO:0042826 histone deacetylase binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 protein kinase B signaling
GO:0043565 sequence-specific DNA binding
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043621 protein self-association
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051781 positive regulation of cell division
GO:0060037 pharyngeal system development
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071383 cellular response to steroid hormone stimulus
GO:0071456 cellular response to hypoxia
GO:0071899 obsolete negative regulation of estrogen receptor binding
GO:0090734 site of DNA damage
GO:0097162 MADS box domain binding
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000836 positive regulation of androgen secretion
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
NKX3-1TOP1BioGRID, DIP, IntAct17234752 27339988 details
NKX3-1ZNF417BioGRID, IntAct32296183 details
NKX3-1CD200R1LBioGRID, IntAct32296183 details
NKX3-1RNF4BioGRID, IntAct32296183 details
NKX3-1SLC22A18BioGRID, IntAct32296183 details
NKX3-1RHOXF2BioGRID, IntAct32296183 details
NKX3-1SPDEFBioGRID, HPRD11809674 18816836 details
NKX3-1SP1BioGRID16201967 details
NKX3-1SP2BioGRID16201967 details
NKX3-1SP3BioGRID16201967 details
NKX3-1SP4BioGRID16201967 details
NKX3-1SP5BioGRID16201967 details
NKX3-1TOPORSBioGRID18077445 details
NKX3-1WDR77BioGRID12972618 details
NKX3-1HNRNPA0BioGRID18816836 details
NKX3-1MNAT1BioGRID18816836 details
NKX3-1AENBioGRID18816836 details
NKX3-1LMCD1BioGRID18816836 details
NKX3-1TEX264BioGRID18816836 details
NKX3-1CCT7BioGRID18816836 details
NKX3-1RPL37ABioGRID18816836 details
NKX3-1FEM1BBioGRID18816836 details
NKX3-1CHPFBioGRID18816836 details
NKX3-1CKAP4BioGRID18816836 details
NKX3-1RABL6BioGRID18816836 details
NKX3-1MAN2B1BioGRID18816836 details
NKX3-1ND4BioGRID18816836 details
NKX3-1HMG20BBioGRID18816836 details
NKX3-1PEBP1BioGRID18816836 details
NKX3-1PTMSBioGRID18816836 details
NKX3-1CENPXBioGRID18816836 details
NKX3-1RARGBioGRID18816836 details
NKX3-1RPSABioGRID18816836 details
NKX3-1STMN3BioGRID18816836 details
NKX3-1HSP90B1BioGRID18816836 details
NKX3-1TPT1BioGRID18816836 details
NKX3-1EHMT2DIP27339988 details
NKX3-1SRFBioGRID, HPRD10993896 details
NKX3-1HDAC1BioGRID16697957 details
NKX3-1KAT2BBioGRID17602165 details
NKX3-1HIPK2HPRD10559189 details
NKX3-1FAM136ABioGRID, IntAct28514442 details
NKX3-1ELAVL1DIP27339988 details
NKX3-1RNF2DIP27339988 details
NKX3-1ZNF655DIP27339988 details
NKX3-1NR3C1DIP27339988 details
NKX3-1POLR2BDIP27339988 details
NKX3-1SENP5DIP27339988 details
NKX3-1EHMT1DIP27339988 details
NKX3-1NCOR1IntAct23518348 details
NKX3-1SIAH2IntAct23518348 details
NKX3-1ARIntAct23518348 details