Entity Details

Primary name SHMT1
Entity type gene
Source Source Link

Details

PrimaryID6470
RefseqGeneNG_017111
SymbolSHMT1
Nameserine hydroxymethyltransferase 1
Chromosome17
Location17p11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-07-14
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGLYC_HUMAN

GO terms

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GOName
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0004372 glycine hydroxymethyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0008732 L-allo-threonine aldolase activity
GO:0009113 purine nucleobase biosynthetic process
GO:0017148 negative regulation of translation
GO:0019264 glycine biosynthetic process from serine
GO:0030170 pyridoxal phosphate binding
GO:0035999 tetrahydrofolate interconversion
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045329 carnitine biosynthetic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
GO:0048027 mRNA 5'-UTR binding
GO:0050897 cobalt ion binding
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0070905 serine binding
GO:1904482 cellular response to tetrahydrofolate
GO:1990830 cellular response to leukemia inhibitory factor

Diseases

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Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
SHMT1PIM1BioGRID, HPRD, IntAct16169070 details
SHMT1PRSS23BioGRID, HPRD, IntAct16169070 details
SHMT1DEDDBioGRID, IntAct21988832 details
SHMT1SULT1A4IntAct25416956 details
SHMT1SULT1A3BioGRID, IntAct25416956 details
SHMT1MAPK9BioGRID, IntAct25416956 31515488 32296183 details
SHMT1SHMT1BioGRID, IntAct25416956 32296183 details
SHMT1GORASP2BioGRID, IntAct32296183 details
SHMT1MDFIBioGRID, IntAct32296183 details
SHMT1DDX6BioGRID, IntAct32296183 details
SHMT1FBXO7BioGRID27503909 details
SHMT1IDH3AMINT30613765 details
SHMT1ABRAXAS2BioGRID24075985 details
SHMT1LZTS2BioGRID29395067 details
SHMT1CSNK2BHPRD10549165 details
SHMT1MAP1LC3BIntAct20562859 details
SHMT1JUNMINT25609649 details
SHMT1HSCBBioGRID, IntAct28380382 details
SHMT1BMT2BioGRID, IntAct28514442 details
SHMT1DPYSL5BioGRID, IntAct28514442 details
SHMT1SHMT2BioGRID, IntAct22863883 28514442 details
SHMT1ARNTBioGRID, IntAct28514442 details
SHMT1FRMD6IntAct28514442 details
SHMT1NBEAL2IntAct29187380 details
SHMT1NDUFS3IntAct27499296 details
SHMT1ATP5F1AIntAct27499296 details
SHMT1ZC3H4BioGRID22939629 details
SHMT1MCATBioGRID22939629 details
SHMT1HSPA1LBioGRID22939629 details
SHMT1APEHBioGRID22863883 details
SHMT1CTTNBioGRID22863883 details
SHMT1CARS1BioGRID22863883 details
SHMT1NIBAN2BioGRID22863883 details
SHMT1GARS1BioGRID22863883 details
SHMT1GSPT2BioGRID22863883 details
SHMT1HARS1BioGRID22863883 details
SHMT1H4C1BioGRID22863883 details
SHMT1IDEBioGRID22863883 details
SHMT1PAWRBioGRID22863883 details
SHMT1ATP6V1C1BioGRID22863883 details
SHMT1C18orf25BioGRID22863883 details
SHMT1PBDC1BioGRID22863883 details
SHMT1GTF2F2BioGRID22863883 details
SHMT1TSNBioGRID22863883 details
SHMT1TTC1BioGRID22863883 details
SHMT1XPO5BioGRID22863883 details
SHMT1SNX2BioGRID22863883 details
SHMT1SNX6BioGRID22863883 details
SHMT1STAT1BioGRID22863883 details
SHMT1VPS29BioGRID22863883 details
SHMT1ARFIP1BioGRID26344197 details
SHMT1ATICBioGRID26344197 details
SHMT1HSPE1BioGRID26344197 details
SHMT1ITPABioGRID26344197 details
SHMT1PGK2BioGRID26344197 details
SHMT1PAICSBioGRID26344197 details
SHMT1PPATBioGRID26344197 details
SHMT1PRRC1BioGRID26344197 details
SHMT1SMAD4BioGRID26344197 details
SHMT1STXBP1BioGRID26344197 details
SHMT1IFNAR1BioGRID24075985 details
SHMT1EGLN3BioGRID26972000 details
SHMT1PLEKHA4BioGRID31091453 details
SHMT1CHMP4CBioGRID31586073 details
SHMT1BCAR1BioGRID33001583 details
SHMT1RBM39BioGRID28302793 details
SHMT1CUL4ABioGRID32235678 details
SHMT1DNAJA2BioGRID33957083 details
SHMT1ILF3BioGRID31772275 details