Entity Details

Primary name DOCK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92608
EntryNameDOCK2_HUMAN
FullNameDedicator of cytokinesis protein 2
TaxID9606
Evidenceevidence at protein level
Length1830
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesDOCK2

GO terms

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GOName
GO:0001766 membrane raft polarization
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006935 chemotaxis
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0030036 actin cytoskeleton organization
GO:0035580 specific granule lumen
GO:0042608 T cell receptor binding
GO:0043312 neutrophil degranulation
GO:0043547 positive regulation of GTPase activity
GO:0044351 macropinocytosis
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0046633 alpha-beta T cell proliferation
GO:0050690 regulation of defense response to virus by virus
GO:0050766 positive regulation of phagocytosis
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR026791 Dedicator of cytokinesisFamilyFamily
IPR026799 Dedicator of cytokinesis protein 2FamilyFamily
IPR027007 C2 DOCK-type domainDomainDomain
IPR027357 DOCKER domainDomainDomain
IPR032376 Dedicator of cytokinesis, N-terminal domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1FamilyHomologous superfamily
IPR043161 Dedicator of cytokinesis, C-terminal, lobe AFamilyHomologous superfamily
IPR043162 Dedicator of cytokinesis, C-terminal, lobe CFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616433 OMIMImmunodeficiency 40 (IMD40)A form of combined immunodeficiency characterized by lymphopenia, and defective T-cell, B-cell, and NK-cell responses. Patients suffer from severe invasive bacterial and viral infections in early childhood and may die without bone marrow transplantation. The disease is caused by variants affecting the gene represented in this entry.

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
DOCK2_HUMANRAC1_HUMANBioGRID, HPRD, MINT10559471 12134158 15723800 details
DOCK2_HUMANPLS1_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANTRI23_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANCCDB1_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANKRA59_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANHNRPK_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANKR108_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANKR109_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANCACO2_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANMTUS2_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANKHDR2_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANK1C40_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANNT2NA_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANMDFI_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANKRA94_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANKRA92_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANKRA42_HUMANBioGRID, IntAct25416956 details
DOCK2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKRA93_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKR123_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKR107_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANNT2NC_HUMANBioGRID, IntAct25416956 32296183 details
DOCK2_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANTGM1_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANCAR10_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKR171_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANPCSK5_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANTEN4_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKHDR3_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKRA57_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANKRA33_HUMANBioGRID, IntAct32296183 details
DOCK2_HUMANRAC2_HUMANBioGRID, DIP, HPRD10559471 14737186 details
DOCK2_HUMANELMO1_HUMANBioGRID, DIP14737186 21930703 details
DOCK2_HUMANADA10_HUMANUniProt25036101 details
DOCK2_HUMANTAU_HUMANIntAct32814053 details
DOCK2_HUMANLITAF_HUMANIntAct32814053 details
DOCK2_HUMANPAK2_HUMANBioGRID12176041 details
DOCK2_HUMANKHDR1_HUMANBioGRID22745667 details
DOCK2_HUMANKR101_HUMANBioGRID25416956 details
DOCK2_HUMANKR103_HUMANBioGRID25416956 details
DOCK2_HUMANKRA13_HUMANBioGRID32296183 details
DOCK2_HUMANMPIP2_HUMANIntAct17353931 details
DOCK2_HUMANCD3Z_HUMANBioGRID, HPRD, IntAct12176041 25241761 details
DOCK2_HUMANCRKL_HUMANBioGRID, HPRD12393632 details
DOCK2_HUMANVAV_HUMANBioGRID, HPRD12393632 details
DOCK2_HUMANTERF1_HUMANBioGRID20811636 details
DOCK2_HUMANLRCH2_HUMANBioGRID32203420 details