Entity Details

Primary name KAT6A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92794
EntryNameKAT6A_HUMAN
FullNameHistone acetyltransferase KAT6A
TaxID9606
Evidenceevidence at protein level
Length2004
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesKAT6A

GO terms

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GOName
GO:0000786 nucleosome
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006323 DNA packaging
GO:0006334 nucleosome assembly
GO:0006473 protein acetylation
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016407 acetyltransferase activity
GO:0016573 histone acetylation
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0030099 myeloid cell differentiation
GO:0042393 histone binding
GO:0043966 histone H3 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070776 MOZ/MORF histone acetyltransferase complex
GO:0090398 cellular senescence
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002717 Histone acetyltransferase domain, MYST-typeDomainDomain
IPR005818 Linker histone H1/H5, domain H15DomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR016181 Acyl-CoA N-acyltransferaseFamilyHomologous superfamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR031280 Histone acetyltransferase KAT6AFamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR040706 MYST, zinc finger domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616268 OMIMArboleda-Tham syndrome (ARTHS)An autosomal dominant disorder characterized by intellectual disability, dysmorphic facial features, delayed psychomotor development, and lack of speech. The disease is caused by variants affecting the gene represented in this entry.