Entity Details

Primary name IFT74_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96LB3
EntryNameIFT74_HUMAN
FullNameIntraflagellar transport protein 74 homolog
TaxID9606
Evidenceevidence at protein level
Length600
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesIFT74

GO terms

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GOName
GO:0003334 keratinocyte development
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005929 cilium
GO:0007219 Notch signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0030992 intraciliary transport particle B
GO:0031410 cytoplasmic vesicle
GO:0031514 motile cilium
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035735 intraciliary transport involved in cilium assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048487 beta-tubulin binding
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060271 cilium assembly
GO:0097542 ciliary tip
GO:1905515 non-motile cilium assembly

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR029602 Intraflagellar transport protein 74FamilyFamily

Diseases

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Disease IDSourceNameDescription
617119 OMIMBardet-Biedl syndrome 20 (BBS20)A form of Bardet-Biedl syndrome, a syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
IFT74_HUMANIFT81_HUMANBioGRID, IntAct26186194 27173435 28514442 32296183 unassigned1312 details
IFT74_HUMANDISC1_HUMANBioGRID, IntAct31413325 32296183 details
IFT74_HUMANK1328_HUMANIntAct32296183 details
IFT74_HUMANSMCE1_HUMANBioGRID, IntAct32296183 details
IFT74_HUMANHGS_HUMANBioGRID, IntAct32296183 details
IFT74_HUMANUBX10_HUMANBioGRID26389662 details
IFT74_HUMANIFT46_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
IFT74_HUMANIFT27_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANIFT22_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
IFT74_HUMANIFT20_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANIF172_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANIFT25_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANIFT52_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
IFT74_HUMANTT30B_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
IFT74_HUMANIFT56_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANIFT80_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANTT30A_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
IFT74_HUMANIFT57_HUMANBioGRID, IntAct26186194 27173435 28514442 unassigned1312 details
IFT74_HUMANMIPT3_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANIFT88_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANCC28B_HUMANBioGRID, IntAct27173435 unassigned1312 details
IFT74_HUMANTERA_HUMANBioGRID26389662 details
IFT74_HUMANUFD1_HUMANBioGRID26389662 details
IFT74_HUMANNPL4_HUMANBioGRID26389662 details
IFT74_HUMANOBI1_HUMANBioGRID29395067 details
IFT74_HUMANTULP3_HUMANBioGRID33187986 details