Entity Details

Primary name VPS35_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96QK1
EntryNameVPS35_HUMAN
FullNameVacuolar protein sorting-associated protein 35
TaxID9606
Evidenceevidence at protein level
Length796
SequenceStatuscomplete
DateCreated2002-11-25
DateModified2021-06-02

Ontological Relatives

GenesVPS35

GO terms

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GOName
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0006886 intracellular protein transport
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016241 regulation of macroautophagy
GO:0030904 retromer complex
GO:0030906 retromer, cargo-selective complex
GO:0031647 regulation of protein stability
GO:0031748 D1 dopamine receptor binding
GO:0032268 regulation of cellular protein metabolic process
GO:0032456 endocytic recycling
GO:0036010 protein localization to endosome
GO:0042147 retrograde transport, endosome to Golgi
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045056 transcytosis
GO:0050728 negative regulation of inflammatory response
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0060548 negative regulation of cell death
GO:0070062 extracellular exosome
GO:0090141 positive regulation of mitochondrial fission
GO:0097422 tubular endosome
GO:0099073 mitochondrion-derived vesicle
GO:0099074 mitochondrion to lysosome transport
GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane
GO:1901215 negative regulation of neuron death
GO:1902823 negative regulation of late endosome to lysosome transport
GO:1902950 regulation of dendritic spine maintenance
GO:1903364 positive regulation of cellular protein catabolic process
GO:1905606 regulation of presynapse assembly
GO:2000331 regulation of terminal button organization

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome
Endosome
Late endosome
Membrane

Domains

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DomainNameCategoryType
IPR005378 Vacuolar protein sorting-associated protein 35FamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR042491 Vacuolar protein sorting-associated protein 35, C-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614203 OMIMParkinson disease 17 (PARK17)An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
VPS35_HUMANZ512B_HUMANBioGRID, MINT15231748 details
VPS35_HUMANMTR1B_HUMANBioGRID, HPRD, IntAct17215244 26514267 details
VPS35_HUMANVEGFA_HUMANBioGRID, IntAct21988832 details
VPS35_HUMANVP26A_HUMANBioGRID, DIP, IntAct, UniProt11102511 15078903 16732284 17891154 22863883 22939629 24344282 24747528 24819384 26186194 26344197 26496610 28514442 29893854 32296183 details
VPS35_HUMANVPS29_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11102511 17891154 22863883 22939629 24344282 24747528 25416956 25502805 26344197 28514442 29893854 31515488 32296183 details
VPS35_HUMANMPRI_HUMANUniProt15078903 details
VPS35_HUMANVP26B_HUMANBioGRID, HPRD, IntAct16190980 22939629 26186194 26344197 26496610 28514442 32296183 details
VPS35_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
VPS35_HUMANWAC2C_HUMANBioGRID20923837 24819384 details
VPS35_HUMANSNX3_HUMANBioGRID22673115 24344282 details
VPS35_HUMANRAB7A_HUMANBioGRID24344282 29893854 details
VPS35_HUMANNRAM2_HUMANBioGRID24344282 details
VPS35_HUMANDRD1_HUMANBioGRID27460146 details
VPS35_HUMANVHL_HUMANIntAct17353931 details
VPS35_HUMANGBRL2_HUMANIntAct17353931 details
VPS35_HUMANHLAB_HUMANIntAct17353931 details
VPS35_HUMANTRAF6_HUMANIntAct17353931 details
VPS35_HUMANAAKB1_HUMANIntAct17353931 details
VPS35_HUMANATG9A_HUMANMINT24603492 details
VPS35_HUMANSNX1_HUMANBioGRID, HPRD, UniProt11102511 26344197 details
VPS35_HUMANTBCD5_HUMANBioGRID, UniProt20923837 22354992 details
VPS35_HUMANDISC1_HUMANIntAct31413325 details
VPS35_HUMANMUL1_HUMANBioGRID20619655 details
VPS35_HUMANHGS_HUMANBioGRID19874558 details
VPS35_HUMANMAGL2_HUMANBioGRID23452853 details
VPS35_HUMANVPS35_HUMANBioGRID23452853 details
VPS35_HUMANAIMP2_HUMANBioGRID28383562 details
VPS35_HUMANLAMP2_HUMANBioGRID28383562 details
VPS35_HUMANEEA1_HUMANBioGRID29891722 details
VPS35_HUMANMMP14_HUMANBioGRID29891722 details
VPS35_HUMANPRKN_HUMANBioGRID29893854 details
VPS35_HUMANRAB5A_HUMANBioGRID29893854 details
VPS35_HUMANLAMP1_HUMANBioGRID29893854 details
VPS35_HUMANGOGA4_HUMANBioGRID29893854 details
VPS35_HUMANWASH1_HUMANBioGRID29893854 details