Entity Details

Primary name PDC10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BUL8
EntryNamePDC10_HUMAN
FullNameProgrammed cell death protein 10
TaxID9606
Evidenceevidence at protein level
Length212
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesPDCD10

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001525 angiogenesis
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0019901 protein kinase binding
GO:0030335 positive regulation of cell migration
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0036481 intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:0042542 response to hydrogen peroxide
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0044319 wound healing, spreading of cells
GO:0045747 positive regulation of Notch signaling pathway
GO:0047485 protein N-terminus binding
GO:0050821 protein stabilization
GO:0051683 establishment of Golgi localization
GO:0070062 extracellular exosome
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090168 Golgi reassembly
GO:0090316 positive regulation of intracellular protein transport
GO:0090443 FAR/SIN/STRIPAK complex
GO:1903358 regulation of Golgi organization
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR009652 Programmed cell death protein 10FamilyFamily

Diseases

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Disease IDSourceNameDescription
603285 OMIMCerebral cavernous malformations 3 (CCM3)A congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. The disease is caused by variants affecting the gene represented in this entry.