Entity Details

Primary name ADA33_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BZ11
EntryNameADA33_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 33
TaxID9606
Evidenceevidence at protein level
Length813
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesADAM33

GO terms

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GOName
GO:0004222 metalloendopeptidase activity
GO:0006508 proteolysis
GO:0008270 zinc ion binding
GO:0016021 integral component of membrane

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR018358 Disintegrin, conserved siteSiteConserved site
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR034027 Reprolysin domain, adamalysin-typeDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
600807 OMIMAsthma (ASTHMA)The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
ADA33_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
ADA33_HUMANATX7_HUMANBioGRID, IntAct21078624 details
ADA33_HUMANZNT2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ADA33_HUMANCLC7A_HUMANBioGRID, IntAct25416956 32296183 details
ADA33_HUMANLMNA_HUMANBioGRID24623722 details
ADA33_HUMANB3AT_HUMANBioGRID32296183 details
ADA33_HUMANPKHO1_HUMANBioGRID32296183 details
ADA33_HUMANNB5R3_HUMANBioGRID32296183 details
ADA33_HUMANAQP9_HUMANBioGRID32296183 details
ADA33_HUMAN3HIDH_HUMANBioGRID32296183 details
ADA33_HUMANOPRM_HUMANBioGRID32296183 details
ADA33_HUMANTNF14_HUMANBioGRID32296183 details
ADA33_HUMANSTML3_HUMANBioGRID32296183 details
ADA33_HUMANT106C_HUMANBioGRID32296183 details
ADA33_HUMANTM14B_HUMANBioGRID32296183 details
ADA33_HUMANS22AN_HUMANBioGRID32296183 details
ADA33_HUMANSC11A_HUMANBioGRID32296183 details
ADA33_HUMANFCG2A_HUMANBioGRID32296183 details
ADA33_HUMANTM237_HUMANBioGRID32296183 details
ADA33_HUMANCR3L1_HUMANBioGRID32296183 details
ADA33_HUMANVMA21_HUMANBioGRID32296183 details
ADA33_HUMANASGR2_HUMANBioGRID32296183 details
ADA33_HUMANSGCB_HUMANBioGRID32296183 details
ADA33_HUMANCLD2_HUMANBioGRID32296183 details
ADA33_HUMANBTNL9_HUMANBioGRID32296183 details
ADA33_HUMANSPIT1_HUMANBioGRID32296183 details
ADA33_HUMANGGT6_HUMANBioGRID32296183 details
ADA33_HUMANEPGN_HUMANBioGRID32296183 details
ADA33_HUMANMUC1_HUMANBioGRID32296183 details
ADA33_HUMANNCTR1_HUMANBioGRID32296183 details
ADA33_HUMANCD3E_HUMANBioGRID32296183 details
ADA33_HUMANS35E2_HUMANBioGRID32296183 details