Entity Details

Primary name GREM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H772
EntryNameGREM2_HUMAN
FullNameGremlin-2
TaxID9606
Evidenceevidence at transcript level
Length168
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesGREM2

GO terms

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GOName
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0008201 heparin binding
GO:0009887 animal organ morphogenesis
GO:0010172 embryonic body morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0036122 BMP binding
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0048018 receptor ligand activity
GO:0060300 regulation of cytokine activity

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR004133 DANDomainDomain
IPR006207 Cystine knot, C-terminalDomainDomain
IPR017159 Gremlin-1/2FamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617275 OMIMTooth agenesis, selective, 9 (STHAG9)A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG9 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
GREM2_HUMANBMP2_HUMANHPRD15039429 details
GREM2_HUMANBMP4_HUMANHPRD15039429 details