Entity Details

Primary name TOPRS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NS56
EntryNameTOPRS_HUMAN
FullNameE3 ubiquitin-protein ligase Topors
TaxID9606
Evidenceevidence at protein level
Length1045
SequenceStatuscomplete
DateCreated2006-04-18
DateModified2021-06-02

Ontological Relatives

GenesTOPORS

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000922 spindle pole
GO:0000930 gamma-tubulin complex
GO:0003677 DNA binding
GO:0003823 antigen binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005814 centriole
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010842 retina layer formation
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0030496 midbody
GO:0032391 photoreceptor connecting cilium
GO:0034504 protein localization to nucleus
GO:0035845 photoreceptor cell outer segment organization
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044547 DNA topoisomerase binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0046872 metal ion binding
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051457 maintenance of protein location in nucleus
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
609923 OMIMRetinitis pigmentosa 31 (RP31)A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. The disease is caused by variants affecting the gene represented in this entry.

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
TOPRS_HUMANSNIP1_HUMANHPRD, MINT15231748 details
TOPRS_HUMANP53_HUMANBioGRID, HPRD, MINT10415337 11842245 15247280 16122737 17290218 17803295 details
TOPRS_HUMANCASP8_HUMANBioGRID, HPRD, MINT17290218 details
TOPRS_HUMANUB2D1_HUMANBioGRID, IntAct15247280 18077445 19053840 19690564 details
TOPRS_HUMANUB2D2_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUB2D3_HUMANBioGRID, IntAct15247280 19690564 details
TOPRS_HUMANUB2D4_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUB2J1_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUB2L6_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUBE2N_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUBE2W_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANSATB1_HUMANBioGRID, IntAct18408014 20351170 details
TOPRS_HUMANSETX_HUMANUniProt24244371 details
TOPRS_HUMANUBC9_HUMANBioGRID, HPRD14516784 16122737 details
TOPRS_HUMANSUMO1_HUMANBioGRID, HPRD11842245 14516784 16524884 details
TOPRS_HUMANTOP1_HUMANBioGRID, HPRD10352183 17976381 20805487 details
TOPRS_HUMANHABP4_HUMANBioGRID, HPRD16455055 details
TOPRS_HUMANSIN3A_HUMANBioGRID17803295 details
TOPRS_HUMANPLK1_HUMANBioGRID19473992 19821153 22972498 details
TOPRS_HUMANNKX31_HUMANBioGRID18077445 details
TOPRS_HUMANPAIRB_HUMANBioGRID, HPRD16679534 details
TOPRS_HUMANH2AX_HUMANBioGRID22972498 details
TOPRS_HUMANUB2E1_HUMANBioGRID15247280 details
TOPRS_HUMANSUMO2_HUMANBioGRID16524884 details
TOPRS_HUMANLYRIC_HUMANBioGRID24529480 details
TOPRS_HUMANUBC_HUMANBioGRID15247280 details
TOPRS_HUMANEPM2A_HUMANBioGRID26493215 details
TOPRS_HUMANPRS4_HUMANBioGRID26872363 details
TOPRS_HUMANSPOP_HUMANBioGRID29996942 details
TOPRS_HUMANXRCC1_HUMANBioGRID29668892 details
TOPRS_HUMANCBP_HUMANBioGRID28680062 details
TOPRS_HUMANTOPRS_HUMANHPRD11842245 details
TOPRS_HUMANAPOE_HUMANIntAct31413325 details
TOPRS_HUMANGTF2I_HUMANBioGRID17803295 details
TOPRS_HUMANNONO_HUMANBioGRID17803295 details
TOPRS_HUMANSFPQ_HUMANBioGRID17803295 details
TOPRS_HUMANPARP1_HUMANBioGRID17803295 details
TOPRS_HUMANSAFB2_HUMANBioGRID17803295 details
TOPRS_HUMANDDB2_HUMANBioGRID17803295 details
TOPRS_HUMANRBBP7_HUMANBioGRID17803295 details
TOPRS_HUMANTIF1B_HUMANBioGRID17803295 details
TOPRS_HUMANRBBP4_HUMANBioGRID17803295 details
TOPRS_HUMANSMRC2_HUMANBioGRID17803295 details
TOPRS_HUMANDHX15_HUMANBioGRID17803295 details
TOPRS_HUMANHNRPL_HUMANBioGRID17803295 details
TOPRS_HUMANRAGP1_HUMANBioGRID17803295 details
TOPRS_HUMANREN3A_HUMANBioGRID17803295 details
TOPRS_HUMANHNRPM_HUMANBioGRID17803295 details
TOPRS_HUMANROA1_HUMANBioGRID17803295 details
TOPRS_HUMANSF3B1_HUMANBioGRID17803295 details
TOPRS_HUMANEF1A1_HUMANBioGRID17803295 details
TOPRS_HUMANS10A9_HUMANBioGRID17803295 details
TOPRS_HUMANIKKE_HUMANBioGRID20188669 details
TOPRS_HUMANPML_HUMANBioGRID20188669 details