Entity Details

Primary name TRM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NXH9
EntryNameTRM1_HUMAN
FullNametRNA (guanine(26)-N(2))-dimethyltransferase
TaxID9606
Evidenceevidence at protein level
Length659
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesTRMT1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0002940 tRNA N2-guanine methylation
GO:0003723 RNA binding
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006400 tRNA modification
GO:0046872 metal ion binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000571 Zinc finger, CCCH-typeDomainDomain
IPR002905 tRNA methyltransferase, Trm1FamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR036855 Zinc finger, CCCH-type superfamilyFamilyHomologous superfamily
IPR042296 tRNA methyltransferase, Trm1, C-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618302 OMIMIntellectual developmental disorder, autosomal recessive 68 (MRT68)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions