Entity Details

Primary name CCG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y698
EntryNameCCG2_HUMAN
FullNameVoltage-dependent calcium channel gamma-2 subunit
TaxID9606
Evidenceevidence at protein level
Length323
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCACNG2

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006612 protein targeting to membrane
GO:0007528 neuromuscular junction development
GO:0009986 cell surface
GO:0016247 channel regulator activity
GO:0019226 transmission of nerve impulse
GO:0030666 endocytic vesicle membrane
GO:0032281 AMPA glutamate receptor complex
GO:0035255 ionotropic glutamate receptor binding
GO:0036477 somatodendritic compartment
GO:0044300 cerebellar mossy fiber
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060081 membrane hyperpolarization
GO:0060082 eye blink reflex
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098839 postsynaptic density membrane
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0099590 neurotransmitter receptor internalization
GO:1904510 positive regulation of protein localization to basolateral plasma membrane
GO:2000311 regulation of AMPA receptor activity
GO:2000969 positive regulation of AMPA receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Membrane

Domains

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DomainNameCategoryType
IPR004031 PMP-22/EMP/MP20/Claudin superfamilyFamilyFamily
IPR005422 Voltage-dependent calcium channel, gamma-2 subunitFamilyFamily
IPR008368 Voltage-dependent calcium channel, gamma subunitFamilyFamily

Diseases

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Disease IDSourceNameDescription
614256 OMIMMental retardation, autosomal dominant 10 (MRD10)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule